Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti 3 C 2 T x ) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation

2020 ◽  
Vol 9 (19) ◽  
pp. 2000872
Author(s):  
Lin Mao ◽  
Sanming Hu ◽  
Yihua Gao ◽  
Li Wang ◽  
Weiwei Zhao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Electrical Stimulation ◽  
Bacterial Cellulose ◽  
Wound Dressing ◽  
Skin Wound ◽  
Composite Hydrogel ◽  
Skin Wound Healing

scholarly journals Keratin Scaffolds Containing Casomorphin Stimulate Macrophage Infiltration and Accelerate Full-Thickness Cutaneous Wound Healing in Diabetic Mice

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2554
Author(s):  
Marek Konop ◽  
Anna K. Laskowska ◽  
Mateusz Rybka ◽  
Ewa Kłodzińska ◽  
Dorota Sulejczak ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Diabetic Mice ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Impaired Wound Healing

Impaired wound healing is a major medical challenge, especially in diabetics. Over the centuries, the main goal of tissue engineering and regenerative medicine has been to invent biomaterials that accelerate the wound healing process. In this context, keratin-derived biomaterial is a promising candidate due to its biocompatibility and biodegradability. In this study, we evaluated an insoluble fraction of keratin containing casomorphin as a wound dressing in a full-thickness surgical skin wound model in mice (n = 20) with iatrogenically induced diabetes. Casomorphin, an opioid peptide with analgesic properties, was incorporated into keratin and shown to be slowly released from the dressing. An in vitro study showed that keratin-casomorphin dressing is biocompatible, non-toxic, and supports cell growth. In vivo experiments demonstrated that keratin-casomorphin dressing significantly (p < 0.05) accelerates the whole process of skin wound healing to the its final stage. Wounds covered with keratin-casomorphin dressing underwent reepithelization faster, ending up with a thicker epidermis than control wounds, as confirmed by histopathological and immunohistochemical examinations. This investigated dressing stimulated macrophages infiltration, which favors tissue remodeling and regeneration, unlike in the control wounds in which neutrophils predominated. Additionally, in dressed wounds, the number of microhemorrhages was significantly decreased (p < 0.05) as compared with control wounds. The dressing was naturally incorporated into regenerating tissue during the wound healing process. Applied keratin dressing favored reconstruction of more regular skin structure and assured better cosmetic outcome in terms of scar formation and appearance. Our results have shown that insoluble keratin wound dressing containing casomorphin supports skin wound healing in diabetic mice.

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing

Biomaterials ◽  
2018 ◽  
Vol 183 ◽  
pp. 185-199 ◽  
Author(s):  
Jin Qu ◽  
Xin Zhao ◽  
Yongping Liang ◽  
Tianlong Zhang ◽  
Peter X. Ma ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Skin Wound ◽  
Self Healing ◽  
Skin Wound Healing ◽  
Injectable Hydrogels

scholarly journals A Novel Multilayer Composite Membrane for Wound Healing in Mice Skin Defect Model

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 573 ◽  
Author(s):  
Yuyu Qiu ◽  
Qingqing Wang ◽  
Yajun Chen ◽  
Shufang Xia ◽  
Wei Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Animal Experiments ◽  
Skin Wound ◽  
Control Group ◽  
Skin Defect ◽  
Multilayer Composite ◽  
Defect Model ◽  
Skin Wound Healing

To develop a wound dressing material that conforms to the healing process, we prepared a multilayer composite (MC) membrane consisting of an antibacterial layer (ABL), a reinforcement layer (RFL), and a healing promotion layer (HPL). Biocompatible zein/ethyl cellulose (zein/EC) electrospun nanofibrous membranes with in situ loaded antibacterial photosensitizer protoporphyrin (PPIX) and healing promotion material vaccarin (Vac) were, respectively, chosen as the ABL on the surface and the HPL on the bottom, between which nonwoven incorporated bacterial cellulose (BC/PETN) as the HPL was intercalated to enhance the mechanical property. Photodynamic antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was confirmed by the enlarged inhibition zones; meanwhile, satisfactory biocompatibility of the HPL was verified by scanning electronic microscopy (SEM) of L929 cells cultured on its surface. The potential effects on wound healing in a mice skin defect model of the MC membranes were also evaluated. The animal experiments demonstrated that the wound healing rate in the MC group was significantly increased compared with that in the control group (p < 0.05). Histopathological observation revealed an alleviated inflammatory response, accompanied with vascular proliferation in the MC group. The MC membranes significantly promoted wound healing by creating an antibacterial environment and promoting angiogenesis. Taken together, this MC membrane may act as a promising wound dressing for skin wound healing.

Accelerated Skin Wound Healing by Electrical Stimulation

2021 ◽  
pp. 2100557
Author(s):  
Ruizeng Luo ◽  
Jieyu Dai ◽  
Jiaping Zhang ◽  
Zhou Li
Keyword(s):  
Wound Healing ◽  
Electrical Stimulation ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Anodal and cathodal pulsed electrical stimulation on skin wound healing in guinea pigs

2007 ◽  
Vol 44 (4) ◽  
pp. 611 ◽  
Author(s):  
Fereshte Ghayebi Mehmandoust ◽  
Giti Torkaman ◽  
Mohammad Firoozabadi ◽  
Gadamali Talebi
Keyword(s):  
Wound Healing ◽  
Electrical Stimulation ◽  
Guinea Pigs ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Song Wang ◽  
Huachao Yang ◽  
Zhenrui Tang ◽  
Gang Long ◽  
Wen Huang
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Rate ◽  
Skin Wound ◽  
Human Umbilical Cord ◽  
Paracrine Signaling ◽  
Skin Wound Healing ◽  
Alginate Gel ◽  
Calcium Alginate Gel ◽  
Wound Healing Rate

Purpose. To probe growth characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) cultured with alginate gel scaffolds, and to explore feasibility of wound dressing model of hUCMSCs-alginates compound.Methods. hUCMSCs were isolated, cultured, and identified in vitro. Then cells were cultivated in 100 mM calcium alginate gel, and the capacity of proliferation and migration and the expression of vascular endothelial growth factors (VEGF) were investigated regularly. Wound dressing model of hUCMSCs-alginate gel mix was transplanted into Balb/c mice skin defects. Wound healing rate and immunohistochemistry were examined.Results. hUCMSCs grew well but with little migration ability in the alginate gel. Compared with control group, a significantly larger cell number and more VEGF expression were shown in the gel group after culturing for 3–6 days (P< 0.05). In addition, a faster skin wound healing rate with more neovascularization was observed in the hUCMSCs-alginate gel group than in control groups at 15th day after surgery (P< 0.05).Conclusion. hUCMSCs can proliferate well and express massive VEGF in calcium alginate gel porous scaffolds. Wound dressing model of hUCMSCs-alginate gel mix can promote wound healing through paracrine signaling.

Surface-structured bacterial cellulose loaded with hUSCs accelerate skin wound healing by promoting angiogenesis in rats

2019 ◽  
Vol 516 (4) ◽  
pp. 1167-1174 ◽  
Author(s):  
Yi-meng Cao ◽  
Meng-yu Liu ◽  
Zhuo-wei Xue ◽  
Yu Qiu ◽  
Jie Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bacterial Cellulose ◽  
Skin Wound ◽  
Skin Wound Healing

A double-network polysaccharide-based composite hydrogel for skin wound healing

2021 ◽  
pp. 117870
Author(s):  
Yuxin He ◽  
Yang Li ◽  
Yadong Sun ◽  
Shijia Zhao ◽  
Miao Feng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Composite Hydrogel ◽  
Skin Wound Healing ◽  
Double Network
Sign in / Sign up

Export Citation Format

Share Document