scholarly journals Bone Tissue Engineering: A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self‐Sustained Endochondral Ossification (Adv. Healthcare Mater. 13/2021)

2021 ◽  
Vol 10 (13) ◽  
pp. 2170060
Author(s):  
Hwan D. Kim ◽  
Xuechong Hong ◽  
Young‐Hyeon An ◽  
Mihn Jeong Park ◽  
Do‐Gyoon Kim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Endochondral Ossification ◽  
Biomimetic Scaffold

A graded graphene oxide-hydroxyapatite/silk fibroin biomimetic scaffold for bone tissue engineering

2017 ◽  
Vol 80 ◽  
pp. 232-242 ◽  
Author(s):  
Qian Wang ◽  
Yanyan Chu ◽  
Jianxin He ◽  
Weili Shao ◽  
Yuman Zhou ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Biomimetic Scaffold

Investigation on the Biomimetic Scaffold for Bone Tissue Engineering Based on Bioglass-Collagen-Hyaluronic Acid-Phosphatidylserine

2007 ◽  
Vol 330-332 ◽  
pp. 939-942 ◽  
Author(s):  
Xiao Feng Chen ◽  
Ying Jun Wang ◽  
Na Ru Zhao ◽  
Chun Rong Yang
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Porous Structure ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Type I Collagen ◽  
Type I ◽  
High Porosity ◽  
Culture Methods ◽  
Biomimetic Scaffold

The new type of bone tissue engineering scaffold composed of the sol-gel derived bioactive glass particles, type I collagen, hyaluronic acid and phosphatidylserine were prepared through cross-linking and freeze-drying techniques. SEM observation indicated that the scaffold possessed a 3-D interconnected porous structure and a high porosity. The properties of bio-mineralization and cells biocompatibility were investigated using SBF immersion and cells culture methods combined with SEM, XRD and FTIR techniques. The study revealed that this biomimetic scaffold possessed satisfactory functions of cells attachment, bio-mineralization, and cells biocompatibility. The porous structure and the surface of the scaffold which was covered by a bone-like HA crystal layer due to bio-mineralization were profitable for cells attachment and spread.

Bone tissue engineering via application of a collagen/hydroxyapatite 4D-printed biomimetic scaffold for spinal fusion

2021 ◽  
Vol 8 (2) ◽  
pp. 021403
Author(s):  
Hanjun Hwangbo ◽  
Hyeongjin Lee ◽  
Eun Ji Roh ◽  
WonJin Kim ◽  
Hari Prasad Joshi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Spinal Fusion ◽  
Bone Tissue ◽  
Biomimetic Scaffold

Preparation and Characterization of a Multilayer Biomimetic Scaffold for Bone Tissue Engineering

2007 ◽  
Vol 22 (3) ◽  
pp. 223-239 ◽  
Author(s):  
Lijun Kong ◽  
Qiang Ao ◽  
Aijun Wang ◽  
Kai Gong ◽  
Xi Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomimetic Scaffold

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

PLGA+HA/βTCP scaffold incorporating simvastatin: a promising biomaterial for bone tissue engineering

2020 ◽  
Author(s):  
Mariane Beatriz Sordi ◽  
Ariadne Cristiane Cabral da Cruz ◽  
Águedo Aragones ◽  
Mabel Mariela Rodríguez Cordeiro ◽  
Ricardo de Souza Magini
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Thermal Analyses ◽  
Chemical Properties ◽  
Biological Properties ◽  
Scanning Calorimetry ◽  
Evaporation Technique ◽  
Porosity Analysis ◽  
Biphasic Ceramic

The aim of this study was to synthesize, characterize, and evaluate degradation and biocompatibility of poly(lactic-co-glycolic acid) + hydroxyapatite / β-tricalcium phosphate (PLGA+HA/βTCP) scaffolds incorporating simvastatin (SIM) to verify if this biomaterial might be promising for bone tissue engineering. Samples were obtained by the solvent evaporation technique. Biphasic ceramic particles (70% HA, 30% βTCP) were added to PLGA in a ratio of 1:1. Samples with SIM received 1% (m:m) of this medication. Scaffolds were synthesized in a cylindric-shape and sterilized by ethylene oxide. For degradation analysis, samples were immersed in PBS at 37 °C under constant stirring for 7, 14, 21, and 28 days. Non-degraded samples were taken as reference. Mass variation, scanning electron microscopy, porosity analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and thermogravimetry were performed to evaluate physico-chemical properties. Wettability and cytotoxicity tests were conducted to evaluate the biocompatibility. Microscopic images revealed the presence of macro, meso, and micropores in the polymer structure with HA/βTCP particles homogeneously dispersed. Chemical and thermal analyses presented very similar results for both PLGA+HA/βTCP and PLGA+HA/βTCP+SIM. The incorporation of simvastatin improved the hydrophilicity of scaffolds. Additionally, PLGA+HA/βTCP and PLGA+HA/βTCP+SIM scaffolds were biocompatible for osteoblasts and mesenchymal stem cells. In summary, PLGA+HA/βTCP scaffolds incorporating simvastatin presented adequate structural, chemical, thermal, and biological properties for bone tissue engineering.

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