Silk Microneedle Patch Capable of On‐Demand Multidrug Delivery to the Brain for Glioblastoma Treatment (Adv. Mater. 1/2022)

By learning how to teach ‘grit’ and creating the concept ‘prelive’ it is now possible to teach how to get into the zone on demand. A group of 24 second graders were taught how to work a Rubik’s Cube. Ten students mastered the cube and all continued to work the cube for the entire academic year. During this process it was learned how to teach ‘grit’ through perseverance.While learning how confidence is developed in business executives, salespersons and athletes the concept of ‘prelive’ was developed. ‘Prelive’ is a way to activate the brain in believing an event or task has been successfully executed before it has actually happened. When an individual imagines a positive result has happened to such a degree of intensity, before it has happened, the individual, at times, may experience zoneness which results in superior performance.A sequence of events leading to zoneness is presented, illustrating pedagogical best practices for teaching how to get into the zone on demand.

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Real brain waves

Behavioral and Brain Sciences ◽

10.1017/s0140525x00373253 ◽

2000 ◽

Vol 23 (3) ◽

pp. 412-413

Author(s):

Don M. Tucker

Keyword(s):

Distributed Representation ◽

On Demand ◽

Brain Waves ◽

The Brain

Metaphors, particularly the implicit ones, constrain imagination. If we think of the brain as a collection of centers of cognitive activations, lighting up on demand, then this becomes all we can imagine. By thinking of the cortex as propagating its functional work through physical waves, Nunez offers us a new, rich model for distributed representation. Now let's add real anatomy.

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Decoding voluntary movements and postural tremor based on thalamic LFPs for closed-loop stimulation for essential tremor

10.1101/436709 ◽

2018 ◽

Cited By ~ 2

Author(s):

Huiling Tan ◽

Jean Debarros ◽

Alek Pogosyan ◽

Tipu Z. Aziz ◽

Yongzhi Huang ◽

...

Keyword(s):

Essential Tremor ◽

High Frequency ◽

Closed Loop ◽

Voluntary Movements ◽

Postural Tremor ◽

On Demand ◽

Upper Limb Movements ◽

Motor Thalamus ◽

The Brain ◽

Deep Brain

AbstractHigh frequency deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET). However, conventional continuous stimulation may deliver unnecessary current to the brain since tremor mainly affects voluntary movements and sustained postures in ET. We recorded LFPs from the motor thalamus, surface electromyographic (EMG) signals and/or behavioural measurements in seven ET patients during temporary lead externalization after the first surgery for DBS when they performed different voluntary upper limb movements and in nine more patients during the surgery, when they were asked to lift their arms to trigger postural tremor. We show that both voluntary movements and postural tremor can be decoded based on features extracted from thalamic LFPs using a machine learning based binary classifier. This information can be used to close the loop for DBS so that stimulation could be delivered on demand, without the need for peripheral sensors or additional invasive electrodes.

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