scholarly journals De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects

2021 ◽  
pp. 2101716
Author(s):  
Lizhen Xu ◽  
Heng Zhang ◽  
Yunfei Wang ◽  
Xiancui Lu ◽  
Zhenye Zhao ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Design ◽  
Allosteric Modulators ◽  
Analgesic Effects ◽  
Positive Allosteric Modulators

scholarly journals De Novo Design of Peptidic Positive Allosteric Modulators Targeting TRPV1 with Analgesic Effects (Adv. Sci. 17/2021)

2021 ◽  
Vol 8 (17) ◽  
pp. 2170104
Author(s):  
Lizhen Xu ◽  
Heng Zhang ◽  
Yunfei Wang ◽  
Xiancui Lu ◽  
Zhenye Zhao ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Design ◽  
Allosteric Modulators ◽  
Analgesic Effects ◽  
Positive Allosteric Modulators

SAR Studies on mGlu5 Receptor Positive Allosteric Modulators (2003- 2013)

2014 ◽  
Vol 14 (15) ◽  
pp. 1789-1841 ◽  
Author(s):  
Junliang Hao ◽  
Hui Xiong
Keyword(s):  
Allosteric Modulators ◽  
Sar Studies ◽  
Positive Allosteric Modulators

Molecular Modeling, de novo Design and Synthesis of a Novel, Extracellular Binding Fibroblast Growth Factor Receptor 2 Inhibitor Alofanib (RPT835)

2016 ◽  
Vol 12 (4) ◽  
pp. 303-317 ◽  
Author(s):  
Ilya Tsimafeyeu ◽  
Frits Daeyaert ◽  
Jean-Baptiste Joos ◽  
Koen V. Aken ◽  
John Ludes-Meyers ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
De Novo ◽  
Growth Factor Receptor ◽  
De Novo Design ◽  
Fibroblast Growth ◽  
Design And Synthesis

Exploration of Novel MTH1 Inhibitors Using Fragment-Based de novo Design, Virtual Screening, and Reverse Virtual Screening Methods

2019 ◽  
Vol 45 (4) ◽  
pp. 391-391
Author(s):  
Xin-yu Zhao ◽  
Kai Liu ◽  
Xiao-li Wang ◽  
Ri-lei Yu ◽  
Cong-min Kang
Keyword(s):  
Virtual Screening ◽  
De Novo ◽  
De Novo Design ◽  
Screening Methods ◽  
Reverse Virtual Screening

Towards the de novo design of DNA based catalytic sites using a combined NMR and in silico approach

2014 ◽  
Author(s):  
Dieter Buyst ◽  
V. Gheerardijn ◽  
J. Van Den Begin ◽  
A. Madder ◽  
J. C. Martins
Keyword(s):  
In Silico ◽  
De Novo ◽  
De Novo Design ◽  
Catalytic Sites

scholarly journals A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects

2021 ◽  
pp. 108673
Author(s):  
Kerri D. Pryce ◽  
Hye Jin Kang ◽  
Farhana Sakloth ◽  
Yongfeng Liu ◽  
Susan Khan ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Opioid Receptor ◽  
Allosteric Modulators ◽  
Μ Opioid Receptor ◽  
Positive Allosteric Modulators

scholarly journals De Novo Design of Selective Quadruplex‐Duplex Junction Ligands and Structural Characterisation of their Binding Mode: Targeting the G4 Hot‐Spot

2020 ◽  
Author(s):  
Laura Díaz-Casado ◽  
Israel Serrano-Chacón ◽  
Laura Montalvillo-Jiménez ◽  
Francisco Corzana ◽  
Agatha Bastida ◽  
...  
Keyword(s):  
De Novo ◽  
Hot Spot ◽  
Binding Mode ◽  
De Novo Design ◽  
Structural Characterisation

scholarly journals De novo design of modular and tunable protein biosensors

Nature ◽  
2021 ◽  
Author(s):  
Alfredo Quijano-Rubio ◽  
Hsien-Wei Yeh ◽  
Jooyoung Park ◽  
Hansol Lee ◽  
Robert A. Langan ◽  
...  
Keyword(s):  
De Novo ◽  
De Novo Design
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