scholarly journals A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real‐Time Tumor‐Tracking and Photothermal‐Enhanced Chemotherapy

2021 ◽  
pp. 2102256
Author(s):  
Tao Sun ◽  
Guangping Zhang ◽  
Tingting Ning ◽  
Qinjun Chen ◽  
Yongchao Chu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Real Time ◽  
Peritoneal Metastases ◽  
Tumor Tracking

RPS24c Isoform Facilitates Tumor Angiogenesis Via Promoting the Stability of MVIH in Colorectal Cancer

2020 ◽  
Vol 20 (5) ◽  
pp. 388-395 ◽  
Author(s):  
Yue Wang ◽  
Youjun Wu ◽  
Kun Xiao ◽  
Yingjie Zhao ◽  
Gang Lv ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ribosomal Protein ◽  
Real Time ◽  
Tumor Angiogenesis ◽  
Real Time Pcr ◽  
Molecular Mechanisms ◽  
Migration And Invasion ◽  
Binding Interaction ◽  
Tubule Formation ◽  
The Stability

Background: Colorectal cancer (CRC) is the second leading cause of death worldwide, and distant metastasis is responsible for the poor prognosis in patients with advanced-stage CRC. RPS24 (ribosomal protein S24) as a ribosomal protein, multiple transcript variant encoding different isoforms have been found for this gene. Our previous studies have demonstrated that RPS24 is overexpressed in CRC. However, the mechanisms underlying the role of RPS24 in tumor development have not been fully defined. Methods: Expression of RPS24 isoforms and lncRNA MVIH in CRC tissues and cell lines were quantified by real-time PCR or western blotting assay. Endothelial tube formation assay was performed to determine the effect of RPS24 on tumor angiogenesis. The cell viability of HUVEC was determined by MTT assay, and the migration and invasion ability of HUVEC were detected by transwell assay. PGK1 secretion was tested with a specific ELISA kit. Results: Here, we found that RPS24c isoform was a major contributor to tumor angiogenesis, a vital process in tumor growth and metastasis. Real-time PCR revealed that RPS24c isoform was highly expressed in CRC tissues, while other isoforms are present in both normal and CRC tissues with no statistical difference. Moreover the change of RPS24 protein level is mainly due to the fluctuation of RPS24c. Furthermore, we observed that silencing RPS24c could decrease angiogenesis by inhibiting tubule formation, HUVEC cell proliferation and migration. Additionally, we investigated the molecular mechanisms and demonstrated that RPS24c mRNA interacted with lncRNA MVIH, the binding-interaction enhanced the stability of each other, thereby activated angiogenesis by inhibiting the secretion of PGK1. Conclusion: RPS24c facilitates tumor angiogenesis via the RPS24c/MVIH/PGK1 pathway in CRC. RPS24c inhibition may be a novel option for anti-vascular treatment in CRC.

scholarly journals Dedicated MRI staging versus surgical staging of peritoneal metastases in colorectal cancer patients considered for CRS-HIPEC; the DISCO randomized multicenter trial

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
M. P. Engbersen ◽  
C. J. V. Rijsemus ◽  
J. Nederend ◽  
A. G. J. Aalbers ◽  
I. H. J. T. de Hingh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Diagnostic Laparoscopy ◽  
Controlled Trial ◽  
Peritoneal Metastases ◽  
Surgical Staging ◽  
Mri Findings ◽  
Mri Staging ◽  
Multicenter Randomized Controlled Trial ◽  
Colorectal Cancer Patients

Abstract Background Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Computed tomography generally underestimates the peritoneal tumor load. Diagnostic laparoscopy is often used to determine whether patients are amenable for surgery. Magnetic resonance imaging (MRI) has shown to be accurate in predicting completeness of CRS. The aim of this study is to determine whether MRI can effectively reduce the need for surgical staging. Methods The study is designed as a multicenter randomized controlled trial (RCT) of colorectal cancer patients who are deemed eligible for CRS-HIPEC after conventional CT staging. Patients are randomly assigned to either MRI based staging (arm A) or to standard surgical staging with or without laparoscopy (arm B). In arm A, MRI assessment will determine whether patients are eligible for CRS-HIPEC. In borderline cases, an additional diagnostic laparoscopy is advised. The primary outcome is the number of unnecessary surgical procedures in both arms defined as: all surgeries in patients with definitely inoperable disease (PCI > 24) or explorative surgeries in patients with limited disease (PCI < 15). Secondary outcomes include correlations between surgical findings and MRI findings, cost-effectiveness, and quality of life (QOL) analysis. Conclusion This randomized trial determines whether MRI can effectively replace surgical staging in patients with CRCPM considered for CRS-HIPEC. Trial registration Registered in the clinical trials registry of U.S. National Library of Medicine under NCT04231175.

PO-1600: Evaluation of a High Dynamic Multileaf Collimator for Real-Time tumor tracking

2020 ◽  
Vol 152 ◽  
pp. S870-S871
Author(s):  
C. Murillo ◽  
S. Seeber ◽  
P. Haering ◽  
C. Lang ◽  
M. Splinter
Keyword(s):  
Real Time ◽  
Multileaf Collimator ◽  
Tumor Tracking ◽  
High Dynamic

Peritoneal cytology as an indicator of peritoneal metastases in colorectal cancer

2021 ◽  
Author(s):  
Paul H. Sugarbaker ◽  
Tom Deng ◽  
David Chang
Keyword(s):  
Colorectal Cancer ◽  
Peritoneal Metastases ◽  
Peritoneal Cytology

scholarly journals Real-Time Lung Tumor Tracking Using a CUDA Enabled Nonrigid Registration Algorithm for MRI

2020 ◽  
Vol 8 ◽  
pp. 1-8
Author(s):  
Nazanin Tahmasebi ◽  
Pierre Boulanger ◽  
Jihyun Yun ◽  
Gino Fallone ◽  
Michelle Noga ◽  
...  
Keyword(s):  
Real Time ◽  
Lung Tumor ◽  
Nonrigid Registration ◽  
Registration Algorithm ◽  
Tumor Tracking

427. Progress classification of the synchronous peritoneal metastases of colorectal cancer – Discussion from a prognosis

2014 ◽  
Vol 40 (11) ◽  
pp. S163
Author(s):  
H. Sato ◽  
Y. Koide ◽  
M. Shiota ◽  
S. Matsuoka ◽  
K. Hatta ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Peritoneal Metastases

High dose three-dimensional conformal boost (3DCB) using an orthogonal diagnostic X-ray set-up for patients with gynecological malignancy: a new application of real-time tumor-tracking system

2004 ◽  
Vol 73 (2) ◽  
pp. 219-222 ◽  
Author(s):  
Ritsu Yamamoto ◽  
Akio Yonesaka ◽  
Seiko Nishioka ◽  
Hidemichi Watari ◽  
Takayuki Hashimoto ◽  
...  
Keyword(s):  
Real Time ◽  
Tracking System ◽  
Three Dimensional ◽  
High Dose ◽  
X Ray ◽  
Gynecological Malignancy ◽  
Tumor Tracking ◽  
Set Up

Feasibility of synchronization of real-time tumor-tracking radiotherapy and intensity-modulated radiotherapy from viewpoint of excessive dose from fluoroscopy

2004 ◽  
Vol 60 (1) ◽  
pp. 335-341 ◽  
Author(s):  
Hiroki Shirato ◽  
Masataka Oita ◽  
Katsuhisa Fujita ◽  
Yoshiharu Watanabe ◽  
Kazuo Miyasaka
Keyword(s):  
Real Time ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
Tumor Tracking
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