Trisomy 9 mosaic syndrome: Sixteen additional patients with new and/or less commonly reported features, literature review, and suggested clinical guidelines

Author(s):  
Mindy Li ◽  
Jennifer Glass ◽  
Xiaoli Du ◽  
Holly Dubbs ◽  
Margaret Horton Harr ◽  
...  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Mariia A. Slepukhina ◽  
Dmitriy V. Ivashchenko ◽  
Maria A. Sheina ◽  
Andranik Alexandrovich Muradian ◽  
Dmitriy Alexeevich Blagovestnov ◽  
...  

AbstractPain is a significant problem in medicine. The use of PGx markers to personalize postoperative analgesia can increase its effectiveness and avoid undesirable reactions. This article describes the mechanisms of nociception and antinociception and shows the pathophysiological mechanisms of pain in the human body. The main subject of this article is pharmacogenetic approach to the selection of anesthetics. Current review presents data for local and general anesthetics, opioids, and non-steroidal anti-inflammatory drugs. None of the anesthetics currently has clinical guidelines for pharmacogenetic testing. This literature review summarizes the results of original research available, to date, and draws attention to this area.


2019 ◽  
Vol 1 (1) ◽  
pp. 40-45

Purpose: The objective of this paper is to review concepts of this type of occlusion and provide clinical guidelines based on the currently available literature. Materials and Methods: A literature review was conducted in MEDLINE and PubMed since September 2015 to January 2016. Results: The database searches resulted in 1481potentially relevant articles. After inclusion/exclusion criteria 41 articles were considered. Conclusions: Based on the literature reviewed it can be concluded that the objective of implant-protected occlusion is to minimize occlusal overload on the implant / bone interface and on prostheses keeping the masticatory loads within physiological limits, providing stability and longevity to rehabilitation treatments with implants.


2020 ◽  
pp. 1-9
Author(s):  
Colin Drummond ◽  
Miriam Hillyard ◽  
Marja Leonhardt ◽  
Frieder Wurst ◽  
Geert Dom ◽  
...  

<b><i>Background:</i></b> Alcohol is a leading cause of morbidity and mortality in the European region, and tackling the harmful use of alcohol is a public health priority. Most countries in the region have national strategies for treating alcohol use disorders (AUD), but there is significant between-country variation. <b><i>Objectives:</i></b> This study aimed to compare clinical guidelines for the management of AUD from countries of the European region and to determine whether countries’ relative wealth or quality of their health systems had affected the guidelines. <b><i>Methods:</i></b> A survey was conducted of 24 countries. The survey encompassed how AUD clinical guidelines were researched, the range and expertise of contributors, which topics of AUD treatment were included, the definition of a “standard drink” used, and the publishing, funding, endorsement, and dissemination of the guideline. <b><i>Results:</i></b> Twenty-one of the 24 countries surveyed had a clinical guideline for AUD. All guidelines were underpinned by a literature review, and psychiatrists were the professional group most commonly involved in producing them. Most of the guidelines covered typical cornerstones of AUD care such as treatment of alcohol dependence, pharmacotherapy for relapse prevention, and detoxification. Definitions of a “standard drink” ranged from 8 to 20 grams of ethanol. Governments or governmental bodies were the main publishers and funders of guidelines, and the vast majority of guidelines were freely available online. There were no statistically significant effects of GDP, GDP per capita, or World Health Organization’s World Health Report rankings on whether countries were more likely to have an AUD clinical guideline, to have performed a systematic literature review, or to have involved service users in producing their guideline. <b><i>Conclusions:</i></b> The results of this survey reflect widespread good practice in producing AUD clinical guidelines across European countries. Regional research collaborations could offer significant time and cost savings in producing the evidence base from which guidelines are then written.


2003 ◽  
Vol 14 (1) ◽  
pp. 65-69 ◽  
Author(s):  
F. Stipoljev ◽  
M. Kos ◽  
M. Kos ◽  
B. Miskovi ◽  
R. Matijevic ◽  
...  

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