The role of candidate-geneCNTNAP2in childhood apraxia of speech and specific language impairment

2015 ◽  
Vol 168 (7) ◽  
pp. 536-543 ◽  
Author(s):  
T. M. Centanni ◽  
J. N. Sanmann ◽  
J. R. Green ◽  
J. Iuzzini-Seigel ◽  
C. Bartlett ◽  
...  
2015 ◽  
Vol 24 (1) ◽  
pp. 47-59 ◽  
Author(s):  
Pauline Frizelle ◽  
Paul Fletcher

Purpose This study investigated the relationship between 2 components of memory—phonological short-term memory (pSTM) and working memory (WM)—and the control of relative clause constructions in children with specific language impairment (SLI). Method Children with SLI and 2 control groups—an age-matched and a younger group of children with typical development—repeated sentences, including relative clauses, representing 5 syntactic roles and 2 levels of matrix clause complexity. The Working Memory Test Battery for Children was administered. Results All 3 groups showed significant associations between pSTM and both types of matrix clause construction. For children with SLI, significant associations emerged between (a) WM and more complex matrix clause constructions, (b) WM and relative clauses including a range of syntactic roles, and (c) pSTM and the least difficult syntactic role. In contrast, the age-matched control group could repeat almost all syntactic roles without invoking the use of either memory component. Conclusions The role of pSTM and WM in the production of relative clauses by children with SLI is influenced by the degree of difficulty of the structure to be recalled. In therapy, the effect of WM limitations can be minimized by approaching each structure within the context of a simple matrix clause.


1998 ◽  
Vol 41 (6) ◽  
pp. 1363-1374 ◽  
Author(s):  
Laurence B. Leonard ◽  
Umberta Bortolini

Italian-speaking children with specific language impairment (SLI) were compared to a group of younger control children in their use of auxiliary verbs, pronominal clitics, infinitives, present tense verb inflections, and articles. Differences favoring the control children were found for those morphemes that required the production of nonfinal weak syllables. On other grammatical morphemes, the two groups did not differ. A relationship was seen between the use of morphemes requiring nonfinal weak syllables and the use of nonfinal weak syllables that had no morpheme status. The findings are considered from the perspective of both prosodic production limitations and limitations in input processing.


2018 ◽  
Vol 61 (12) ◽  
pp. 3010-3022 ◽  
Author(s):  
Janet Vuolo ◽  
Lisa Goffman

Purpose The aim of the study was to investigate the relationship between language load and articulatory variability in children with language and speech sound disorders, including childhood apraxia of speech. Method Forty-six children, ages 48–92 months, participated in the current study, including children with speech sound disorder, developmental language disorder (aka specific language impairment), childhood apraxia of speech, and typical development. Children imitated (low language load task) then retrieved (high language load task) agent + action phrases. Articulatory variability was quantified using speech kinematics. We assessed language status and speech status (typical vs. impaired) in relation to articulatory variability. Results All children showed increased articulatory variability in the retrieval task compared with the imitation task. However, only children with language impairment showed a disproportionate increase in articulatory variability in the retrieval task relative to peers with typical language skills. Conclusion Higher-level language processes affect lower-level speech motor control processes, and this relationship appears to be more strongly mediated by language than speech skill.


2001 ◽  
Vol 356 (1407) ◽  
pp. 369-380 ◽  
Author(s):  
D. V. M. Bishop

Specific language impairment (SLI) is the term used to refer to unexplained difficulties in language acquisition in children. Over the past decade, there has been rapid growth of evidence indicating that genes play an important part in the aetiology of SLI. However, further progress in elucidating the role of genes in causing SLI is limited by our lack of understanding of the phenotype. Studies to date have been hampered by the fact that we do not know whether SLI should be treated as a discrete disorder or a continuous variable, let alone which measures should be used to identify cases, or how many subtypes there are. Recent research suggests that theoretically motivated measures of underlying processes may be better than conventional clinical diagnoses for identifying aetiologically distinct types of language impairment. There has been a tendency for researchers to embrace parsimony and look for a single cause of SLI—or in any event, to identify different subtypes, each with a different single cause. Research is reviewed that suggests that may not be a fruitful approach to SLI, and that an approach in terms of multiple risk and protective factors, which is widely adopted in medicine, is more realistic.


2012 ◽  
Vol 35 (3) ◽  
pp. 515-545 ◽  
Author(s):  
PATRICIA J. BROOKS ◽  
LIAT SEIGER-GARDNER ◽  
KEVIN SAILOR

ABSTRACTIn picture naming, semantic context words produce either facilitation or inhibition, depending on their relationship to the target-picture name. This study used the picture–word interference task to examine facilitative effects of associates (the word carrot paired with a picture of rabbit) and inhibitory effects of coordinates (mouse paired with a rabbit) in children and adults. Experiment 1 with adults (N = 44) documented robust associate and coordinate effects with either auditory or visual presentation of interfering words. Experiment 2 used auditory presentation of interfering words with children (N = 44, 6 years, 10 months to 11 years, half with typical development, half with specific language impairment). Children showed significant facilitation from associates but no reliable coordinate interference effect. The strength of the associative priming effect in children was correlated with their language abilities (Peabody Picture Vocabulary Test and Clinical Evaluation of Language Fundamentals scores). The results indicate the dominant role of association in facilitating word retrieval in speech production in children. In children with specific language impairment, lexical access gains weaker support from networks of associations in semantic memory.


1996 ◽  
Vol 39 (5) ◽  
pp. 1081-1098 ◽  
Author(s):  
Margaret Lahey ◽  
Jan Edwards

To examine the role of different cognitive processes in accounting for the slower naming times of children with specific language impairment (SLI) relative to peers with no language impairment (NLI), three tasks designed to stress different types of processing were administered: naming pictures with the signal to respond presented at various delay intervals, naming following different durations of exposure to identical and unrelated primes, and vocally responding to nonlinguistic stimuli. Children with SLI, aged 4 to 9.5 years, were significantly slower than their NLI age peers on naming and on responding to nonlinguistic stimuli, but the effect of delay interval before naming and of duration of prime exposure before naming was similar for both groups. Results suggested that speed of naming is related to the slower nonlinguistic response processing of children with SLI and not to speed of their linguistic or perceptual processing. To examine differences in processing that might relate to pattern of language performance we examined responses of two subgroups of SLI. The subgroup of children whose language problems involved expressive but not receptive skills was not significantly slower than their NLI peers. The children whose problems involved both expressive and receptive language were significantly slower, but this was influenced by age. Findings are discussed in terms of language performance, age, task variables, and a generalized rate-limiting factor.


Sign in / Sign up

Export Citation Format

Share Document