scholarly journals A cross-setting study of chimpanzee (Pan troglodytes) personality structure and development: zoological parks and Yerkes National Primate Research Center

2007 ◽  
Vol 69 (11) ◽  
pp. 1264-1277 ◽  
Author(s):  
Alexander Weiss ◽  
James E. King ◽  
William D. Hopkins
Keyword(s):  
Pan Troglodytes ◽  
Research Center ◽  
Personality Structure ◽  
Primate Research ◽  
Zoological Parks ◽  
National Primate Research ◽  
Yerkes National Primate Research

scholarly journals Colon volvulus in rhesus macaques ( Macaca mulatta ) at the Oregon National Primate Research Center—Retrospective analysis

2021 ◽  
Author(s):  
Amanda L. Johnson ◽  
Steven Bronson ◽  
Kamm Prongay ◽  
Reed A. Norris ◽  
Anne D. Lewis
Keyword(s):  
Retrospective Analysis ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Research Center ◽  
Primate Research ◽  
Colon Volvulus ◽  
National Primate Research

scholarly journals Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center

2018 ◽  
Vol 70 (7) ◽  
pp. 449-458 ◽  
Author(s):  
Rebecca A. Morgan ◽  
Julie A. Karl ◽  
Hailey E. Bussan ◽  
Katelyn E. Heimbruch ◽  
David H. O’Connor ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Research Center ◽  
Primate Research ◽  
National Primate Research

scholarly journals Genetic characterization of specific pathogen-free rhesus macaque (Macaca mulatta) populations at the California National Primate Research Center (CNPRC)

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Sree Kanthaswamy ◽  
Alex Kou ◽  
Jessica Satkoski ◽  
Maria Cecilia T. Penedo ◽  
Thea Ward ◽  
...  
Keyword(s):  
Rhesus Macaque ◽  
Macaca Mulatta ◽  
Genetic Characterization ◽  
Research Center ◽  
Primate Research ◽  
Specific Pathogen Free ◽  
Specific Pathogen ◽  
National Primate Research

Association between hybrid status and reproductive success of captive male and female rhesus macaques (Macaca mulatta) at the California National Primate Research Center (CNPRC)

2011 ◽  
Vol 73 (7) ◽  
pp. 671-678 ◽  
Author(s):  
Sree Kanthaswamy ◽  
Parry M.R. Clarke ◽  
Alexander Kou ◽  
Venkat Malladi ◽  
Jessica Satkoski Trask ◽  
...  
Keyword(s):  
Reproductive Success ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Research Center ◽  
Primate Research ◽  
Male And Female ◽  
Female Rhesus ◽  
Female Rhesus Macaques ◽  
National Primate Research

scholarly journals Acute gastrointestinal dilation in laboratory rhesus monkeys in the Korea National Primate Research Center

2012 ◽  
Vol 28 (3) ◽  
pp. 217 ◽  
Author(s):  
Kyoung-Min Kim ◽  
Sang-Rae Lee ◽  
Kwon-Sik Chang ◽  
Yong-Hoon Lee ◽  
Sung-Woo Kim ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Research Center ◽  
Primate Research ◽  
National Primate Research

scholarly journals Neuro-pharmacological reinstatement of ovulation and associated neurobiology in a macaque model of functional hypothalamic amenorrhoea

2020 ◽  
Author(s):  
Cynthia L Bethea ◽  
Judy L Cameron
Keyword(s):  
Menstrual Cycle ◽  
Longitudinal Design ◽  
Cynomolgus Macaque ◽  
Research Center ◽  
Primate Research ◽  
Serum Samples ◽  
Medial Basal Hypothalamus ◽  
Macaque Model ◽  
Cynomolgus Macaques ◽  
National Primate Research

Abstract STUDY QUESTION What is the underlying neuropathology in a cynomolgus macaque model of functional hypothalamic amenorrhoea (FHA) and can it be normalized to restore ovulation? SUMMARY ANSWER Anovulatory monkeys exhibited increased hypothalamic norepinephrine (NE), kisspeptin and gonadotropin-releasing hormone (GnRH) in the early follicular phase, but administration of the NE reuptake inhibitor (NRI), reboxetine (REB), restored ovulation during stress and normalized NE, kisspeptin and GnRH. WHAT IS KNOWN ALREADY Female cynomolgus macaques, like women, show individual reproductive sensitivity to modest psychosocial and metabolic stress. During stress, resilient females ovulate through two menstrual cycles whereas stress-sensitive (SS) macaques immediately cease ovulation. On Day 5 of a non-stressed menstrual cycle, resilient macaques have less NE synthesizing enzyme [dopamine β-hydroxylase (DBH)], kisspeptin and GnRH innervation of the medial basal hypothalamus but more endogenous serotonin than SS macaques. Stress increased DBH/NE, kisspeptin and GnRH but did not alter serotonin. STUDY DESIGN, SIZE, DURATION In a longitudinal design, 27 adult (7–13 years) female cynomolgus macaques (Macaca fascicularis) with three different levels of sensitivity to stress were monitored with daily vaginal swabs and frequent serum progesterone (P) measurements. Three 90-day experimental periods called ‘Cycle Sets’ were monitored. A Cycle Set consisted of one ovulatory menstrual cycle without stress, and two cycles, or 60 days, with modest stress. Each Cycle Set was followed by a rest period. During a Cycle Set, individuals were either untreated (placebo) or administered escitalopram (CIT) or REB. Ultimately, half of each sensitivity group was euthanized during stress with CIT or REB treatment and the hypothalamus was obtained. Neurobiological endpoints were compared between CIT and REB treatment groups in stress resilient and SS monkeys. PARTICIPANTS/MATERIALS, SETTING, METHODS The monkeys were housed at the University of Pittsburgh primate facility for the duration of the experiments. Upon euthanasia, their brains and serum samples were shipped to the Oregon National Primate Research Center. The hypothalamus was examined with immunohistochemistry for the expression of DBH (a marker for NE axons), kisspeptin and GnRH. P was measured in the serum samples by radioimmunoassay. MAIN RESULTS AND THE ROLE OF CHANCE Daily administration of REB restored ovulation in 9 of 10 SS animals during stress. Of note, REB significantly increased P secretion during stress in the most sensitive group (P = 0.032), which indicates ovulation. CIT lacked efficacy. REB significantly reduced DBH/NE, kisspeptin and GnRH axon density in the hypothalamus relative to CIT treatment (P = 0.003. 0.018 and 0.0001, respectively) on Day 5 of the menstrual cycle in resilient and sensitive groups. LARGE SCALE DATA N/A. LIMITATIONS, REASONS FOR CAUTION The US FDA has not approved REB for human use, although it is used in Europe for the treatment of depression/anxiety as EdronaxTR. Whether REB could be useful for the treatment of FHA in women has not been determined. WIDER IMPLICATIONS FOR THE FINDINGS The use of an NRI to treat FHA is a novel approach and the potential reinstatement of ovulation could be straightforward compared to current treatment protocols. The underlying neurobiology provides a compelling case for treating the origin of the pathology, i.e. elevated NE, rather than circumventing the hypothalamus altogether with gonadotropins, which have associated risks such as hyperstimulation syndrome or multiple births. STUDY FUNDING/COMPETING INTEREST(S) Portions of this study were supported by NIH grant HD062864 to C.L.B., NIH grant HD62618 to J.L.C. and C.L.B. and 1P51 OD011092 for the operation of the Oregon National Primate Research Center. There were no competing interests.

scholarly journals Development of a Chinese-Indian hybrid (Chindian) rhesus macaque colony at the California National Primate Research Center by introgression

2009 ◽  
Vol 38 (2) ◽  
pp. 86-96 ◽  
Author(s):  
S. Kanthaswamy ◽  
L. Gill ◽  
J. Satkoski ◽  
V. Goyal ◽  
V. Malladi ◽  
...  
Keyword(s):  
Rhesus Macaque ◽  
Research Center ◽  
Primate Research ◽  
National Primate Research

scholarly journals Four decades of leading-edge research in the reproductive and developmental sciences: The Infant Primate Research Laboratory at the University of Washington National Primate Research Center

2013 ◽  
Vol 75 (11) ◽  
pp. 1063-1083 ◽  
Author(s):  
Thomas M. Burbacher ◽  
Kimberly S. Grant ◽  
Julie Worlein ◽  
James Ha ◽  
Eliza Curnow ◽  
...  
Keyword(s):  
Research Laboratory ◽  
Leading Edge ◽  
Research Center ◽  
Primate Research ◽  
University Of Washington ◽  
The University ◽  
National Primate Research

scholarly journals Divergent Enteroviruses from Macaques with Chronic Diarrhea

2021 ◽  
Vol 10 (31) ◽  
Author(s):  
Kathie A. Mihindukulasuriya ◽  
Lindsay Droit ◽  
Margaret H. Gilbert ◽  
Peter J. Didier ◽  
Anne Paredes ◽  
...  
Keyword(s):  
Macaca Mulatta ◽  
Chronic Diarrhea ◽  
Rhesus Macaques ◽  
Draft Genome ◽  
Research Center ◽  
Primate Research ◽  
Genome Sequences ◽  
Content Type ◽  
The Family ◽  
National Primate Research

We report the draft genome sequences of five novel members of the family Picornaviridae that were isolated from the stool of rhesus macaques ( Macaca mulatta ) with chronic diarrhea. The strains were named NOLA-1 through NOLA-5 because the macaques were residents of the Tulane National Primate Research Center.

Rhesus rhadinovirus infection in healthy and SIV-infected macaques at Tulane National Primate Research Center

2003 ◽  
Vol 32 (1) ◽  
pp. 1-6 ◽  
Author(s):  
K. Ruff ◽  
G.B. Baskin ◽  
L. Simpson ◽  
M. Murphey-Corb ◽  
L.S. Levy
Keyword(s):  
Research Center ◽  
Primate Research ◽  
National Primate Research
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