Associations between sex, body mass index, and the individual microglial response in Alzheimer’s disease

Background: Approximately 40 independent Single Nucleotide Polymorphisms (SNPs) have been associated with Alzheimer’s Disease (AD) or cognitive decline in genome-wide association studies. Methods: We aimed to evaluate the joint effect of genetic polymorphisms and environmental factors on the progression from Mild Cognitive Impairment (MCI) to AD (MCI-AD progression) in a Chinese community cohort. Conclusion: Demographic, DNA and incident AD diagnosis data were derived from the follow-up of 316 participants with MCI at baseline of the Shanghai Aging Study. The associations of 40 SNPs and environmental predictors with MCI-AD progression were assessed using the Kaplan-Meier method with the log-rank test and Cox regression model. Results: Rs4147929 at ATP-binding cassette family A member 7 (ABCA7) (AG/AA vs. GG, hazard ratio [HR] = 2.43, 95% confidence interval [CI] 1.24-4.76) and body mass index (BMI) (overweight vs. non-overweight, HR = 0.41, 95% CI 0.22-0.78) were independent predictors of MCI-AD progression. In the combined analyses, MCI participants with the copresence of non-overweight BMI and the ABCA7 rs4147929 (AG/AA) risk genotype had an approximately 6-fold higher risk of MCI-AD progression than those with an overweight BMI and a non-risk genotype (HR = 6.77, 95% CI 2.60-17.63). However, a nonsignificant result was found when participants carried only one of these two risk factors (nonoverweight BMI and AG/AA of ABCA7 rs4147929). Conclusion: ABCA7 rs4147929 and BMI jointly affect MCI-AD progression. MCI participants with the rs4147929 risk genotype may benefit from maintaining an overweight BMI level with regard to their risk for incident AD.

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Physical activity, body mass index, and brain atrophy in Alzheimer's disease

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2014.05.036 ◽

2015 ◽

Vol 36 ◽

pp. S194-S202 ◽

Cited By ~ 26

Author(s):

Christina P. Boyle ◽

Cyrus A. Raji ◽

Kirk I. Erickson ◽

Oscar L. Lopez ◽

James T. Becker ◽

...

Keyword(s):

Physical Activity ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Body Mass Index ◽

Body Mass ◽

Brain Atrophy

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Body mass index is associated with smaller medial temporal lobe volume in those at risk for Alzheimer's disease

NeuroImage Clinical ◽

10.1016/j.nicl.2019.102156 ◽

2020 ◽

Vol 25 ◽

pp. 102156

Author(s):

Jasmeet P. Hayes ◽

Jena N. Moody ◽

Juan Guzmán Roca ◽

Scott M. Hayes

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Body Mass Index ◽

At Risk ◽

Body Mass ◽

Temporal Lobe ◽

Medial Temporal Lobe

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P4-649: JOINT EFFECT OF ABCA7 RS4147929 AND BODY MASS INDEX ON PROGRESSION FROM MILD COGNITIVE IMPAIRMENT TO ALZHEIMER'S DISEASE IN COMMUNITY PARTICIPANTS: THE SHANGHAI AGING STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.09.015 ◽

2019 ◽

Vol 15 ◽

pp. P1578-P1578

Author(s):

Jianxiong Xi

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Body Mass Index ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Body Mass ◽

Joint Effect ◽

Aging Study

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Corrigendum to ‘Arachidonate 5-Lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index [Šerý et al., J. Neurol. Sci. 362 (2016) 27–32]

Journal of the Neurological Sciences ◽

10.1016/j.jns.2016.05.008 ◽

2016 ◽

Vol 366 ◽

pp. 135

Author(s):

Omar Šerý ◽

Lydia Hlinecká ◽

Jana Povová ◽

Ondřej Bonczek ◽

Tomáš Zeman ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Body Mass Index ◽

Gene Polymorphism ◽

Body Mass

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Determinants and Detection of Low Body Mass Index in Community-Dwelling Adults With Alzheimer's Disease

International Psychogeriatrics ◽

10.1017/s1041610200006220 ◽

2000 ◽

Vol 12 (1) ◽

pp. 87-98 ◽

Cited By ~ 7

Author(s):

Michel Bédard ◽

D. William Molloy ◽

Rhonda Bell ◽

Judy A. Lever

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Body Mass Index ◽

At Risk ◽

Body Mass ◽

Community Dwelling ◽

Assessment Protocol ◽

Geriatric Clinic ◽

Low Body Mass Index ◽

Low Bmi

Objective: To determine the proportion of older adults with Alzheimer's disease presenting to a geriatric clinic with low body mass index (BMI), the proportion of these individuals recognized by clinicians as malnourished, and what patients' characteristics and caregivers' and clinicians' impressions are associated with low BMI. Design: Cross-sectional study. Setting: An outpatient geriatric clinic located in a university-affiliated teaching hospital. Participants: 340 patients with Alzheimer's disease, average age 75 years. Measurements: Individuals with a BMI below 21 were considered at risk of malnutrition. Physical examination and medical information were obtained from patients and caregivers by clinicians using a standardized assessment protocol. Clinicians' impression regarding evidence of malnutrition was obtained. Results: Forty-six patients (16%) had a BMI below 21. Clinicians reported evidence of potential malnutrition in 11 patients, 8 of whom had a BMI below 21. Using logistic regression, we found that women were five times more likely to have a BMI below 21 than men, and that individuals with low cognition were twice as likely to have a BMI below 21 than individuals with higher cognition. Conclusion: The proportion of patients with Alzheimer's disease with a BMI below 21 is similar to that encountered in the general population aged 65+. However, clinicians have difficulty identifying persons at risk of malnutrition according to BMI status. Women with low cognition were at increased risk of having a low BMI. Improvement in the detection of malnutrition is desirable. Further exploration of causal links between cognition and malnutrition is required.

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