Validation of a 4‐item subjective cognitive decline screening questionnaire in cognitively normal older adults

Objective: Although previous studies postulated that physical and cognitive decline codeveloped in preclinical dementia, the interconnected relationship among subjective cognitive complaints (SCCs), objective cognitive performance, and physical activity remained hazy. We investigated the mediating roles of physical activity between subjective and objective cognition. Diffusion tensor imaging (DTI) was utilized to test our hypothesis that brain white matter microstructural changes underlie the physical-cognitive decline in subjective cognitive decline (SCD).Methods: We enrolled cognitively normal older adults aged > 50 years in the Community Medicine Research Center of Keelung Chang Gung Memorial Hospital during 2017–2020. Regression models analyzed mediation effects of physical activity between subjective and objective cognition. The self-reported AD8 questionnaire assessed SCCs. The SCD group, defined by AD8 score ≥ 2, further underwent diffusion MRI scans. Those who agreed to record actigraphy also wore the SOMNOwatch™ for 72 h. Spearman's correlation coefficients evaluated the associations of diffusion indices with physical activity and cognitive performance.Results: In 95 cognitively normal older adults, the AD8 score and the Montreal Cognitive Assessment (MoCA) score were mediated partially by the metabolic equivalent of the International Physical Activity Questionnaire-Short Form (IPAQ-SF MET) and fully by the sarcopenia score SARC-F. That is, the relation between SCCs and poorer cognitive performance was mediated by physical inactivity. The DTI analysis of 31 SCD participants found that the MoCA score correlated with mean diffusivity at bilateral inferior cerebellar peduncles and the pyramids segment of right corticospinal tract [p < 0.05, false discovery rate (FDR) corrected]. The IPAQ-SF MET was associated with fractional anisotropy (FA) at the right posterior corona radiata (PCR) (p < 0.05, FDR corrected). In 15 SCD participants who completed actigraphy recording, the patterns of physical activity in terms of intradaily variability and interdaily stability highly correlated with FA of bilateral PCR and left superior corona radiata (p < 0.05, FDR corrected).Conclusions: This study addressed the role of physical activity in preclinical dementia. Physical inactivity mediated the relation between higher SCCs and poorer cognitive performance. The degeneration of specific white matter tracts underlay the co-development process of physical-cognitive decline in SCD.

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Regional atrophy and cognitive decline depend on definition of subjective cognitive decline

10.1101/2021.04.21.21255752 ◽

2021 ◽

Author(s):

Cassandra Morrison ◽

Mahsa Dadar ◽

Neda Shafiee ◽

Sylvia Villeneuve ◽

D. Louis Collins ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Cognitive Decline ◽

Cognitive Change ◽

Disease Assessment ◽

Subjective Cognitive Decline ◽

Cognitively Normal ◽

Increased Risk ◽

Definition Of

AbstractBackgroundPeople with subjective cognitive decline (SCD) may be at increased risk for Alzheimer’s disease (AD). However, not all studies have observed this increased risk. Inconsistencies may be related to different methods used to define SCD. The current project examined whether four methods of defining SCD (applied to the same sample) results in different patterns of atrophy and future cognitive decline between cognitively normal older adults with (SCD+) and without SCD (SCD-).MethodsMRI scans and questionnaire data for 273 cognitively normal older adults from Alzheimer’s Disease Neuroimaging Initiative were examined. To operationalize SCD we used four common methods: Cognitive Change Index (CCI), Everyday Cognition Scale (ECog), ECog + Worry, and Worry only. A previously validated MRI analysis method (SNIPE) was used to measure hippocampal volume and grading. Deformation-based morphometry was performed to examine volume at regions known to be vulnerable to AD. Logistic regressions were completed to determine whether diagnostic method was associated with volume differences between SCD- and SCD+. Linear mixed effects models were performed to examine the relationship between the definitions of SCD and future cognitive decline.ResultsResults varied between the four methods of defining SCD. Left hippocampal grading was lower in SCD+ than SCD-when using the CCI (p=.041) and Worry (p=.021) definitions. The right (p=.008) and left (p=.003) superior temporal regions were smaller in SCD+ than SCD-, but only with the ECog. SCD+ was associated with greater future cognitive decline measured by Alzheimer’s Disease Assessment Scale, but only with the CCI definition. In contrast, only the ECog definition of SCD was associated with future decline on the Montreal Cognitive Assessment.ConclusionThe current findings suggest that the various methods used to differentiate between SCD- and SCD+ influence whether volume differences and findings of cognitive decline are observed between groups in this retrospective analysis.

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P4-375: SUBJECTIVE COGNITIVE DECLINE BEFORE AND AFTER APOE AND AMYLOID PET DISCLOSURE IN COGNITIVELY NORMAL OLDER ADULTS SCREENING FOR ALZHEIMER'S DISEASE PREVENTION TRIALS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.4046 ◽

2019 ◽

Vol 15 ◽

pp. P1443-P1444

Author(s):

Louisa I. Thompson ◽

Athene K.W. Lee ◽

Randal Williams ◽

Stephen Salloway ◽

Jessica Alber

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Disease Prevention ◽

Cognitive Decline ◽

Subjective Cognitive Decline ◽

Amyloid Pet ◽

Cognitively Normal ◽

Before And After ◽

Prevention Trials

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P3-298: MOOD AND PERSONALITY CHARACTERISTICS IN MILD COGNITIVE IMPAIRMENT, SUBJECTIVE COGNITIVE DECLINE, AND COGNITIVELY NORMAL OLDER ADULTS WITHOUT CURRENT OR LIFETIME HISTORY OF PSYCHIATRIC ILLNESS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.3329 ◽

2019 ◽

Vol 15 ◽

pp. P1050-P1051

Author(s):

Linda Mah ◽

Aliya Ali ◽

Frankie Chan ◽

Mirjam Mulder-Heijstra ◽

Susan Vandermorris ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Decline ◽

Psychiatric Illness ◽

Personality Characteristics ◽

Subjective Cognitive Decline ◽

Cognitively Normal ◽

Lifetime History ◽

History Of

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S3-01-01: SCREENING FOR ALZHEIMER'S DISEASE IN COGNITIVELY NORMAL OLDER ADULTS: SUBJECTIVE COGNITIVE DECLINE VERSUS INFORMANT REPORT

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.04.241 ◽

2014 ◽

Vol 10 ◽

pp. P200-P200

Author(s):

John C. Morris ◽

Joshua Weng ◽

Chengjie Xiong

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Cognitive Decline ◽

Subjective Cognitive Decline ◽

Cognitively Normal ◽

Informant Report

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Likelihood of Participation in Home-Based Cognitive Assessment: The Role of Subjective Cognitive Decline and Age

Innovation in Aging ◽

10.1093/geroni/igaa057.940 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

pp. 293-294

Author(s):

Moriah Splonskowski ◽

Holly Cooke ◽

Claudia Jacova

Keyword(s):

Older Adults ◽

Cognitive Decline ◽

Old Age ◽

Cognitive Assessment ◽

Community Dwelling ◽

Subjective Cognitive Decline ◽

Cognitive State ◽

Home Based ◽

Increased Risk

Abstract Home-based cognitive assessment (HBCA) services are emerging as a convenient alternative to in-clinic cognitive assessment and may aid in mitigating barriers to detecting cognitive impairment (CI). It is unknown which older adults would be likely to participate in HBCA. Here we investigated the role of age and Subjective Cognitive Decline (SCD). SCD has demonstrated an increased risk for progression to CI/dementia. A nation-wide community-dwelling sample of 494 adults age 50+ were recruited via Amazon Mechanical Turk to complete an online survey assessing perceptions around HBCA and SCD. Our sample was 91.9% White and 66.8% female. It consisted of 174 respondents aged 50-60, 265 aged 61- 70, and 55 aged 71-79. Age groups were comparable with respect to their acceptance of cognitive assessment (Range 4-20, higher score=higher acceptance, 7.9±3.3, 8.15±3.2, 8.05±3.43) and SCD-Q total (43.1±5.8, 43.2±5.7, 43.3±5.7). Correlation analysis revealed a relationship between SCD-QSCD total and perceived likelihood of participation in HBCA for those ages 61-70 (r(263) = .222 p = .000), but not for ages 50-60 or 71-79 (r(172) = .102 p = .152; r(53) = -.102 p = .458). Our findings suggest that SCD influences the likelihood of participation in HBCA for older adults’ transitioning to old age (61-70). Findings show that for adults transitioning into old age (61-70), perceived cognitive state influences their likelihood of participation in HBCA. Importantly, concerns about CI/dementia may generate more favorable perceptions of HBCA for this group.

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Perceptual-Cognitive Training Can Improve Cognition in Older Adults with Subjective Cognitive Decline

10.31038/asmhs.2019361 ◽

2019 ◽

Vol 3 (6) ◽

Keyword(s):

Older Adults ◽

Cognitive Decline ◽

Cognitive Training ◽

Subjective Cognitive Decline

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Longitudinal Relationships Between Subjective Cognitive Decline and Objective Memory: Depressive Symptoms Mediate Between-Person Associations

Journal of Alzheimer s Disease ◽

10.3233/jad-210230 ◽

2021 ◽

pp. 1-14

Author(s):

Nikki L. Hill ◽

Sakshi Bhargava ◽

Emily Bratlee-Whitaker ◽

Jennifer R. Turner ◽

Monique J. Brown ◽

...

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Cognitive Decline ◽

Structural Equation ◽

Disease Risk ◽

Well Being ◽

Equation Modeling ◽

Subjective Cognitive Decline ◽

Future Research ◽

Over Time

Background: Subjective cognitive decline (SCD) may be an early indicator of cognitive impairment, but depressive symptoms can confound this relationship. Associations may be influenced by differences between individuals (i.e., between-persons) or how each individual changes in their experiences over time (i.e., within-persons). Objective: We examined depressive symptoms as a mediator of the between- and within-person associations of SCD and objective memory in older adults. Methods: Coordinated analyses were conducted across four datasets drawn from large longitudinal studies. Samples (range: n = 1,889 to n = 15,841) included participants 65 years of age or older with no dementia at baseline. We used multilevel structural equation modeling to examine the mediation of SCD and objective memory through depressive symptoms, as well as direct relationships among SCD, objective memory, and depressive symptoms. Results: Older adults who were more likely to report SCD had lower objective memory on average (between-person associations), and depressive symptoms partially mediated this relationship in three of four datasets. However, changes in depressive symptoms did not mediate the relationship between reports of SCD and declines in objective memory in three of four datasets (within-person associations). Conclusion: Individual differences in depressive symptoms, and not changes in an individual’s depressive symptoms over time, partially explain the link between SCD and objective memory. Older adults with SCD and depressive symptoms may be at greater risk for poor cognitive outcomes. Future research should explore how perceived changes in memory affect other aspects of psychological well-being, and how these relationships influence cognitive decline and Alzheimer’s disease risk.

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