Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

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Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals

Nature Nanotechnology ◽

10.1038/nnano.2008.405 ◽

2009 ◽

Vol 4 (3) ◽

pp. 193-201 ◽

Cited By ~ 131

Author(s):

Oliver T. Bruns ◽

Harald Ittrich ◽

Kersten Peldschus ◽

Michael G. Kaul ◽

Ulrich I. Tromsdorf ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Real Time ◽

Lipoprotein Metabolism ◽

Resonance Imaging

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Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00459.2015 ◽

2016 ◽

Vol 311 (2) ◽

pp. L208-L218 ◽

Cited By ~ 8

Author(s):

Dean O. Kuethe ◽

Piotr T. Filipczak ◽

Jeremy M. Hix ◽

Andrew P. Gigliotti ◽

Raúl San José Estépar ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Lung Injury ◽

Real Time ◽

Critical Role ◽

Lung Mechanics ◽

Therapeutic Effects ◽

Resonance Imaging ◽

Ventilator Induced Lung Injury

Animal models play a critical role in the study of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). One limitation has been the lack of a suitable method for serial assessment of acute lung injury (ALI) in vivo. In this study, we demonstrate the sensitivity of magnetic resonance imaging (MRI) to assess ALI in real time in rat models of VILI. Sprague-Dawley rats were untreated or treated with intratracheal lipopolysaccharide or PBS. After 48 h, animals were mechanically ventilated for up to 15 h to induce VILI. Free induction decay (FID)-projection images were made hourly. Image data were collected continuously for 30 min and divided into 13 phases of the ventilatory cycle to make cinematic images. Interleaved measurements of respiratory mechanics were performed using a flexiVent ventilator. The degree of lung infiltration was quantified in serial images throughout the progression or resolution of VILI. MRI detected VILI significantly earlier (3.8 ± 1.6 h) than it was detected by altered lung mechanics (9.5 ± 3.9 h, P = 0.0156). Animals with VILI had a significant increase in the Index of Infiltration ( P = 0.0027), and early regional lung infiltrates detected by MRI correlated with edema and inflammatory lung injury on histopathology. We were also able to visualize and quantify regression of VILI in real time upon institution of protective mechanical ventilation. Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI.

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Linseed hydrogel based floating drug delivery system for fluoroquinolone antibiotics: Design, in vitro drug release and in vivo real-time floating detection

Saudi Pharmaceutical Journal ◽

10.1016/j.jsps.2020.03.005 ◽

2020 ◽

Vol 28 (5) ◽

pp. 538-549 ◽

Cited By ~ 4

Author(s):

Fatima Akbar Sheikh ◽

Muhammad Ajaz Hussain ◽

Muhammad Umer Ashraf ◽

Muhammad Tahir Haseeb ◽

Muhammad Farid-ul-Haq

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Real Time ◽

Drug Delivery System ◽

In Vitro Drug Release ◽

Floating Drug Delivery ◽

Fluoroquinolone Antibiotics ◽

Floating Drug Delivery System

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Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode magnetic resonance imaging

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.11.84 ◽

2020 ◽

Vol 11 ◽

pp. 1000-1009

Author(s):

Miao Qin ◽

Yueyou Peng ◽

Mengjie Xu ◽

Hui Yan ◽

Yizhu Cheng ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Contrast Agents ◽

Mri Contrast Agents ◽

Clinical Diagnostics ◽

Resonance Imaging ◽

Dual Mode ◽

Mri Contrast ◽

Magnetic Resonance Imaging Mri

The multimodal magnetic resonance imaging (MRI) technique has been extensively studied over the past few years since it offers complementary information that can increase diagnostic accuracy. Simple methods to synthesize contrast agents are necessary for the development of multimodal MRI. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T 1–T 2 dual-mode MRI contrast agents were successfully designed and synthesized. In order to increase hydrophilicity and biocompatibility, the nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA). The results show that iron (Fe) and gadolinium (Gd) were homogeneously distributed throughout the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxation time analysis was performed on the images obtained from the 3.0 T scanner. The results demonstrated that r 1 and r 2 maximum values were 67.57 ± 6.2 and 24.2 ± 1.46 mM−1·s−1, respectively. In vivo T 1- and T 2-weighted images showed that FGDA nanocubes act as a dual-mode contrast agent enhancing MRI quality. Overall, these experimental results suggest that the FGDA nanocubes are interesting tools that can be used to increase MRI quality, enabling accurate clinical diagnostics.

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