Non-invasive, real-time reporting drug release in vitro and in vivo

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

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NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

10.33774/chemrxiv-2021-nftrb ◽

2021 ◽

Author(s):

Biswajit Roy ◽

Rakesh Mengji ◽

Samrat Roy ◽

Bipul Pal ◽

Avijit Jana ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Real Time ◽

Near Infrared ◽

Single Component ◽

Photon Absorption ◽

Real Time Monitoring ◽

Two Photon ◽

Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

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Real-time monitoring of anticancer drug release in vitro and in vivo on titania nanoparticles triggered by external glutathione

Talanta ◽

10.1016/j.talanta.2011.11.049 ◽

2012 ◽

Vol 88 ◽

pp. 631-637 ◽

Cited By ~ 15

Author(s):

Mira Kim ◽

Ji Hye Seo ◽

Won Il Jeon ◽

Mi-Yeon Kim ◽

Keunchang Cho ◽

...

Keyword(s):

Drug Release ◽

Real Time ◽

Anticancer Drug ◽

Titania Nanoparticles ◽

Real Time Monitoring ◽

Release In Vitro

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Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release

Nanoscale ◽

10.1039/c5nr03259h ◽

2015 ◽

Vol 7 (32) ◽

pp. 13503-13510 ◽

Cited By ~ 84

Author(s):

Jinfeng Zhang ◽

Shengliang Li ◽

Fei-Fei An ◽

Juan Liu ◽

Shubin Jin ◽

...

Keyword(s):

Cancer Therapy ◽

Drug Release ◽

Real Time ◽

Real Time Monitoring ◽

Curcumin Nanoparticles ◽

Major Attention ◽

Pharmaceutical Agents

The use of different nanocarriers for delivering hydrophobic pharmaceutical agents to tumor sites has garnered major attention.

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In vivo near-infrared fluorescence imaging of Leishmania amazonensis expressing infrared fluorescence protein (iRFP) for real-time monitoring of cutaneous leishmaniasis in mice

Journal of Microbiological Methods ◽

10.1016/j.mimet.2016.08.003 ◽

2016 ◽

Vol 130 ◽

pp. 189-195 ◽

Cited By ~ 11

Author(s):

Janaina Correia Oliveira ◽

Aline Caroline da Silva ◽

Renato Antonio dos Santos Oliveira ◽

Valéria Rêgo Alves Pereira ◽

Laura Helena Vega Gonzales Gil

Keyword(s):

Cutaneous Leishmaniasis ◽

Real Time ◽

Fluorescence Imaging ◽

Near Infrared ◽

Leishmania Amazonensis ◽

Real Time Monitoring ◽

Near Infrared Fluorescence ◽

Fluorescence Protein ◽

Near Infrared Fluorescence Imaging

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Facile solvothermal synthesis of ultrathin spinel ZnMn2O4 nanospheres: An efficient electrocatalyst for in vivo and in vitro real time monitoring of H2O2

Journal of Electroanalytical Chemistry ◽

10.1016/j.jelechem.2021.115674 ◽

2021 ◽

Vol 900 ◽

pp. 115674

Author(s):

Muthaiah Annalakshmi ◽

Sakthivel Kumaravel ◽

T.S.T. Balamurugan ◽

Shen-Ming Chen ◽

Ju-Liang He

Keyword(s):

Real Time ◽

Solvothermal Synthesis ◽

Real Time Monitoring

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A reversible near-infrared fluorescence probe for the monitoring of HSO3–/H2O2 regulated cycles in vivo

New Journal of Chemistry ◽

10.1039/d1nj03507j ◽

2021 ◽

Author(s):

Qiuying Song ◽

Bo Zhou ◽

Dongyu Zhang ◽

Haijun Chi ◽

Hongmin Jia ◽

...

Keyword(s):

Real Time ◽

Near Infrared ◽

Fluorescence Probe ◽

Redox Homeostasis ◽

Research Field ◽

Fluorescence Probes ◽

Detection Capability ◽

Near Infrared Fluorescence ◽

Real Time Detection

The development of well-designed fluorescence probes for the monitoring redox homeostasis in biosystems has become a desired research field owing to their noninvasive and real-time detection capability in vivo. In...

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