Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: A chinese cohort study

Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018–1.317; p = 0.028) but not in men (HR, 1.499; CI, 0.964–2.331; p = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.

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Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology ◽

10.5152/akd.2013.039 ◽

2012 ◽

Cited By ~ 1

Author(s):

Asli Inci Atar ◽

Omer Caglar Yilmaz ◽

Kayihan Akin ◽

Yusuf Selcoki ◽

Okan Er ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Coronary Arteries ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level ◽

Controlled Study

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High serum uric acid level is a mortality risk factor in peritoneal dialysis patients: a retrospective cohort study

Nutrition & Metabolism ◽

10.1186/s12986-019-0379-y ◽

2019 ◽

Vol 16 (1) ◽

Cited By ~ 2

Author(s):

Shilong Xiang ◽

Xiaohui Zhang ◽

Xishao Xie ◽

Junni Wang ◽

Qin Zhou ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Cohort Study ◽

Peritoneal Dialysis ◽

Uric Acid Level ◽

Retrospective Cohort ◽

Acid Level ◽

Serum Uric Acid Level ◽

High Serum ◽

Dialysis Patients

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P0378SERUM URIC ACID IS ASSOCIATED WITH PROGNOSIS OF LUPUS NEPHRITIS IN FEMALE BUT NOT IN MALE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0378 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Tae Ryon Oh ◽

Hong Sang Choi ◽

Chang Seong Kim ◽

Soo Wan Kim ◽

Eun Hui Bae ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Lupus Nephritis ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Lupus Erythematosus ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level ◽

Cox Proportional Hazards

Abstract Background and Aims Lupus nephritis (LN) is one of the major complications of systemic lupus erythematosus. Early intervention in lupus nephritis is known to benefit patients' prognosis. Recent studies have found an association between hyperuricemia and lupus nephritis, but the sex-specific role of uric acid in lupus nephritis remains unclear. The purpose of this study is to elucidate the relationship between lupus nephritis and hyperuricemia, and to investigate sex differences. Method We retrospectively analyzed 394 patients who diagnosed with LN by renal biopsy. We assessed the effect of serum uric acid on progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was LN progression that was defined as the initiation of dialysis. Results The male had a higher mean of serum uric acid level than female. In the overall patient analysis, every 1 mg / dL increase in baseline uric acid level increased the risk of LN progression by about 16.9%. The serum uric acid level was an independent risk factor for LN progression in female (hazard ratio [HR], 1.177; confidence interval [CI],1.024 to 1.353; P<0.001) but not in male (HR, 1.0351; CI, 0.661 to 1.622; P = 0.880). A sensitivity analysis involving serum uric acid tertile generated consistent and robust results. Conclusion The serum uric acid level was an independent risk factor for LN progression in female but no in male.

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The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females

Journal of Clinical Medicine ◽

10.3390/jcm9010176 ◽

2020 ◽

Vol 9 (1) ◽

pp. 176 ◽

Cited By ~ 2

Author(s):

Tae Ryom Oh ◽

Hong Sang Choi ◽

Chang Seong Kim ◽

Kyung Pyo Kang ◽

Young Joo Kwon ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Proportional Hazards ◽

Serum Uric Acid Level ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model

Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. A total of 4339 patients who diagnosed with IgAN by renal biopsy were retrospectively analyzed. We assessed the association of serum uric acid on IgAN progression using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; p < 0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; p < 0.001) (pinteraction < 0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. In conclusion, the serum uric acid level was an independent risk factor for IgAN progression and its effect was more pronounced among the women compared with that among the men.

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P0376EFFECTS OF HYPERURICEMIA ON THE PROGNOSIS OF IGA NEPHROPATHY AND ITS SEX DIFFERENCE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0376 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Tae Ryon Oh ◽

Hong Sang Choi ◽

Chang Seong Kim ◽

Seong Kwon Ma ◽

Soo Wan Kim ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Proportional Hazards ◽

Serum Uric Acid Level ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model

Abstract Background and Aims Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression, but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. Method A total of 4339 patients were retrospectively analyzed at a university medical school. We assessed the effect of serum uric acid on IgAN progression using Kaplan–Meier survival analyses and Cox proportional hazards models. The study’s primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. Results On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes, but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; P<0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; P<0.001) (Pinteraction <0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. Conclusion The serum uric acid level was an independent risk factor for IgAN progression, and its effect was more pronounced among the women compared with that among the men.

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The study of serum uric acid level in acute ischemic stroke

Medpusle International Journal of Medicine ◽

10.26611/10219315 ◽

2019 ◽

Vol 9 (3) ◽

pp. 212-216

Author(s):

M G Pattewar ◽

Keyword(s):

Uric Acid ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level

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Uric acid levels are critical for non-alcoholic fatty liver disease

10.21203/rs.2.23270/v1 ◽

2020 ◽

Author(s):

Guanqun Chao ◽

Yue Zhu ◽

Lizheng Fang

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Risk Factor ◽

Fatty Liver ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Density Lipoprotein ◽

Diagnostic Threshold

Abstract Background: To clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors.Methods: Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2016 to December 2017.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Statistical analyses were performed using R software.Results: 79492 subjects were analyzed. 56680(71.3%) participants did not have NAFLD, 22812(28.7%) participants had NAFLD. Male, age, BMI, high blood pressure, central obesity, high glycosylated hemoglobin, high serum uric acid, high triglyceride, high total cholesterol, high low density lipoprotein cholesterol (LDL-C), abnormal liver function were risk factors of NAFLD, however, low high-density lipoprotein cholesterol (HDL-C) level was another risk factor of NAFLD.OR value suggested serum uric acid was a robust risk factor for NAFLD in all subgroups.In male group, AUC was 0.656 (95%CI: 0.651-0.661), the optimal diagnostic threshold was 395.5 mol/L, the sensitivity was 61.9%, the specificity was 61.1%, and the yoden index was 0.23. In female group, AUC was 0.716 (95%CI: 0.708-0.724), the optimal diagnostic threshold was 294.5 mol/L, sensitivity was 67.7%, specificity was 64.5%, and the Jordan index was 0.32.Conclusions: Our study suggested that there was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.Contributions to the literature：1. The purpose of this study was to clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors in the physical examination population.2. There was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.3. The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.

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