Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats

2012 ◽  
Vol 64 (8) ◽  
pp. 2601-2610 ◽  
Author(s):  
Toru Takada ◽  
Kotaro Nishida ◽  
Koichiro Maeno ◽  
Kenichiro Kakutani ◽  
Takashi Yurube ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Cytokine Production ◽  
Mechanical Hyperalgesia ◽  
Herniated Disc ◽  
Disc Model

Residual herniated disc material following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease

2012 ◽  
Vol 25 (02) ◽  
pp. 109-115 ◽  
Author(s):  
M. Thomas ◽  
J. M. Weh ◽  
J. Bleedorn ◽  
K. Wells ◽  
W. J. Roach
Keyword(s):  
Intervertebral Disc ◽  
Herniated Disc ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Vertebral Canal ◽  
Telephone Interviews ◽  
Disc Material ◽  
Long Term Follow Up

SummaryObjective: To evaluate the presence of residual disc material within the vertebral canal following hemilaminectomy in chondrodystrophic dogs with thoracolumbar intervertebral disc disease.Methods: Forty dogs were treated by hemilaminectomy. Computed tomography was performed preoperatively and immediately postoperatively. The vertebral canal height, width, area, and herniated disc material area were measured. Maximum filling percentage (MFP), residual disc percentage (RDP), maximum residual filling percentage (MRFP), and residual filling percentage (RFP) were calculated. Clinical outcome was determined by telephone interviews.Results: Residual disc material was present in 100% of the dogs. Mean MFP = 55.4% (range 25.9–82.3%; median 56.9%). Mean RDP = 50.3% (range 2.6–155.8%; median 47.9%). Mean MRFP = 30.8% (range 4.9–60%; median 30.1%). Mean RFP = 19.8% (range 4.8–45%; median 19.0%). All dogs were ambulatory with voluntary urination at the long-term follow-up (range: 88–735 days).Clinical significance: Residual disc was present in all dogs following hemilaminectomy for intervertebral disc disease. Residual disc was not associated with failure to achieve functional recovery in these cases.

Effect of hyperlipidaemia to accelerate intervertebral disc degeneration in the injured rat caudal disc model

2019 ◽  
Vol 24 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Yuedong Zhang ◽  
Meng Si ◽  
Chunpu Li ◽  
Yi Liu ◽  
Yingguang Han ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Disc Model

scholarly journals A biochemical/biophysical 3D FE intervertebral disc model

2010 ◽  
Vol 9 (5) ◽  
pp. 641-650 ◽  
Author(s):  
Y. Schroeder ◽  
J. M. Huyghe ◽  
C. C. van Donkelaar ◽  
K. Ito
Keyword(s):  
Intervertebral Disc ◽  
Disc Model

scholarly journals Spontaneous regression of lumbar herniated disc Case presentation

2015 ◽  
Vol 29 (4) ◽  
pp. 381-384 ◽  
Author(s):  
A. Chiriac ◽  
Giorgiana Ion ◽  
Z. Faiyad ◽  
I. Poeata
Keyword(s):  
Conservative Treatment ◽  
Intervertebral Disc ◽  
Clinical Improvement ◽  
Spontaneous Regression ◽  
Surgical Intervention ◽  
Herniated Disc ◽  
Common Disease ◽  
Intervertebral Disc Herniation ◽  
Case Presentation

Abstract Intervertebral disc herniation is a common disease that usually requires surgical intervention. However, in some cases, neurological symptoms may improve with conservative treatment. In this article, we present a case with spontaneous regression of extruded lumbar herniated disc correlated with clinical improvement and documented with follow up MRI studies.

Computed tomographic and histological findings of Hansen type I intervertebral disc herniation in dogs

2013 ◽  
Vol 26 (05) ◽  
pp. 379-384 ◽  
Author(s):  
C. L. Vitale ◽  
S. C. Essman ◽  
P. Pithua ◽  
J. R. Coates ◽  
K. Kuroki
Keyword(s):  
Intervertebral Disc ◽  
Disc Herniation ◽  
Imaging Modality ◽  
Thoracolumbar Spine ◽  
Herniated Disc ◽  
Intervertebral Disc Herniation ◽  
Type I ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct

SummaryObjective: To evaluate whether noncontrast-enhanced computed tomography (CT) as a stand-alone imaging modality can be used to define the Hansen type I intervertebral disc herniation (IVDH) lesion and also whether the Hounsfield unit (HU) value of herniated disc is relevant to clinical duration and to histopathological chronicity of extruded disc material.Methods: Information from a series of CT studies performed on 45 dogs with a presumptive diagnosis of Hansen type I IVDH was used. Clinical duration of IVDH was estimated based on time from onset of signs per owner communication to time of surgical intervention. Hansen type I IVDH was confirmed at surgery. Retrieved herniated disc was histologically examined. The HU values were analyzed to correlate the clinical duration and histopathological chronicity of the disc lesion.Results: Non-contrast-enhanced CT provided sufficient diagnostic information to plan surgery in 42 of 45 dogs (93%). The value of the HU was significantly higher in clinically chronic cases (n = 12) compared to peracute cases (n = 11) (p <0.05). The HU values were significantly correlated with clinical duration (r = 0.482, p = 0.0008) and histopathological chronicity of the herniated disc (r = 0.408, p = 0.0056).Conclusion: Consistent with the previous reports, the use of non-contrast-enhanced CT alone was sufficient for the diagnosis and surgical planning in most patients with Hansen type I IVDH in the thoracolumbar spine. In addition, the present study suggested that HU values on CT images may be useful in the evaluation of disease chronicity of IVDH.

Computed Tomographic, Myelographic, and Operative Findings in Patients with Suspected Herniated Lumbar Discs

Neurosurgery ◽  
1983 ◽  
Vol 12 (2) ◽  
pp. 184-188 ◽  
Author(s):  
Nazih A. Moufarrij ◽  
Russell W. Hardy ◽  
Meredith A. Weinstein
Keyword(s):  
Computed Tomography ◽  
Intervertebral Disc ◽  
Clinical Diagnosis ◽  
Herniated Disc ◽  
Lumbar Intervertebral Disc ◽  
Disc Protrusion ◽  
Ct Myelography ◽  
Computed Tomographic ◽  
Canal Stenosis ◽  
Operative Findings

Abstract Fifty patients presenting with a suspected herniated lumbar intervertebral disc were evaluated with sector computed tomography (CT). Excluded from this series were patients with prior lumbar laminectomy or a clinical diagnosis of lumbar canal stenosis. Forty-six of the patients also underwent preoperative lumbar myelography. All patients subsequently underwent laminectomy. In 40 patients (80%), CT was positive. In the remaining 10 patients (20%), it was negative; in this group the myelogram correctly predicted the lesion in 8 (80%), Sector CT correctly predicted the nature of the lesion in 24 patients (48%), was incorrect in 14 (28%), and gave incomplete findings in 12 (24%). CT was most accurate when it demonstrated a disc protrusion as the only finding. In this group, sector CT correctly predicted the operative findings in 24 of 25 patients (96%). CT was less accurate when spondylitic compression was diagnosed. This study suggests that sector CT is a useful test in the evaluation of patients with sciatica and that, when a soft herniated disc is demonstrated on CT, myelography may be omitted.

scholarly journals The Clinical Diagnostic Value of Lumbar Intervertebral Disc Herniation Based on MRI Images

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Kangxing Zheng ◽  
Zihuan Wen ◽  
Dehuai Li
Keyword(s):  
Intervertebral Disc ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Facet Joint ◽  
Lumbar Disc ◽  
Herniated Disc ◽  
Intervertebral Disc Herniation ◽  
Facet Joints ◽  
Lumbar Intervertebral Disc ◽  
Lumbar Intervertebral Disc Herniation

MRI was used to measure the changes in the angle of the facet joints of the lumbar spine and analyze the relationship between it and the herniated lumbar intervertebral disc. Analysis of the causes of lumbar disc herniation from the anatomy and morphology of the spine provides a basis for the early diagnosis and prevention of lumbar disc herniation. There is a certain correlation between the changes shown in MRI imaging of lumbar disc herniation and the TCM syndromes of lumbar intervertebral disc herniation. There is a correlation between the syndromes of lumbar disc herniation and the direct signs of MRI: pathological type, herniated position, and degree of herniation. Indirect signs with MR, nerve root compression and dural sac compression, are related. The MRI examination results can help syndrome differentiation to improve its accuracy to a certain extent. MRI has high sensitivity for the measurement of the angle of the facet joints of the lumbar spine and can be used to study the correlation between the changes of the facet joint angles and the herniated disc. Facet joint asymmetry is closely related to lateral lumbar disc herniation, which may be one of its pathogenesis factors. The herniated intervertebral disc is mostly on the sagittal side of the facet joint, and the facet joint angle on the side of the herniated disc is more sagittal. The asymmetry of the facet joints is not related to the central lumbar disc herniation, and the angle of the facet joints on both sides of the central lumbar disc herniation is partial sagittal.

scholarly journals ­CT-Guided Oxygen-Ozone Intradiscal Injection Therapy for Thoracolumbar Intervertebral Disc Herniations (Hansen Type II) in Dogs

2020 ◽  
Author(s):  
Farkhondeh Fahim Dezhban ◽  
Majid Masoudifard ◽  
Mohammad Mehdi Dehghan ◽  
Mohammad Molazem ◽  
Alireza Bahonar ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Intervertebral Disc ◽  
Intervertebral Discs ◽  
Injection Therapy ◽  
Herniated Disc ◽  
Type Ii ◽  
Ct Guided ◽  
Normal Life ◽  
Disc Herniations ◽  
Intradiscal Injection

Abstract Background: The study aims to investigate the treatment of thoracolumbar herniated intervertebral discs (IVD) in dogs using Oxygen-Ozone (O2-O3) intradiscal injection and assess the results using MRI which achieve more accurate details and procedures. Results: All indices were improved after the treatment, while, three were statistically significant at P<0.5. All 3 dogs returned to their normal life after this study. Conclusions: Intradiscal O2-O3 injection reduces the size of the herniated disc via disc shrinkage and decreasing the pressure of herniated part on the spinal cord.

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