White matter volume in the brainstem and inferior parietal lobule is related to motor performance in children with autism spectrum disorder: A voxel-based morphometry study

2016 ◽  
Vol 9 (9) ◽  
pp. 981-992 ◽  
Author(s):  
Ryuzo Hanaie ◽  
Ikuko Mohri ◽  
Kuriko Kagitani-Shimono ◽  
Masaya Tachibana ◽  
Junko Matsuzaki ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Motor Performance ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Inferior Parietal Lobule ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Matter Volume ◽  
Parietal Lobule

Voxel-based meta-analysis of regional white-matter volume differences in autism spectrum disorder versus healthy controls

2010 ◽  
Vol 41 (7) ◽  
pp. 1539-1550 ◽  
Author(s):  
J. Radua ◽  
E. Via ◽  
M. Catani ◽  
D. Mataix-Cols
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Diffusion Tensor ◽  
Meta Analysis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Sensitivity Analyses ◽  
Healthy Controls ◽  
White Matter Volume ◽  
Matter Volume

BackgroundWe conducted a meta-analysis of voxel-based morphometry (VBM) studies in autism spectrum disorder (ASD) to clarify the changes in regional white-matter volume underpinning this condition, and generated an online database to facilitate replication and further analyses by other researchers.MethodPubMed, ScienceDirect, Web of Knowledge and Scopus databases were searched between 2002 (the date of the first white-matter VBM study in ASD) and 2010. Manual searches were also conducted. Authors were contacted to obtain additional data. Coordinates were extracted from clusters of significant white-matter difference between patients and controls. A new template for white matter was created for the signed differential mapping (SDM) meta-analytic method. A diffusion tensor imaging (DTI)-derived atlas was used to optimally localize the changes in white-matter volume.ResultsThirteen datasets comprising 246 patients with ASD and 237 healthy controls met inclusion criteria. No between-group differences were found in global white-matter volumes. ASD patients showed increases of white-matter volume in the right arcuate fasciculus and also in the left inferior fronto-occipital and uncinate fasciculi. These findings remained unchanged in quartile and jackknife sensitivity analyses and also in subgroup analyses (pediatric versus adult samples).ConclusionsPatients with ASD display increases of white-matter volume in tracts known to be important for language and social cognition. Whether the results apply to individuals with lower IQ or younger age and whether there are meaningful neurobiological differences between the subtypes of ASD remain to be investigated.

Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorder

2004 ◽  
Vol 35 (4) ◽  
pp. 561-570 ◽  
Author(s):  
SASKIA J. M. C. PALMEN ◽  
HILLEKE E. HULSHOFF POL ◽  
CHANTAL KEMNER ◽  
HUGO G. SCHNACK ◽  
SARAH DURSTON ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Gray Matter ◽  
Brain Volume ◽  
Gray Matter Volume ◽  
Children With Autism ◽  
Autism Spectrum ◽  
High Functioning ◽  
Matter Volume ◽  
Children With Asd

Background. To establish whether high-functioning children with autism spectrum disorder (ASD) have enlarged brains in later childhood, and if so, whether this enlargement is confined to the gray and/or to the white matter and whether it is global or more prominent in specific brain regions.Method. Brain MRI scans were acquired from 21 medication-naive, high-functioning children with ASD between 7 and 15 years of age and 21 comparison subjects matched for gender, age, IQ, height, weight, handedness, and parental education, but not pubertal status.Results. Patients showed a significant increase of 6% in intracranium, total brain, cerebral gray matter, cerebellum, and of more than 40% in lateral and third ventricles compared to controls. The cortical gray-matter volume was evenly affected in all lobes. After correction for brain volume, ventricular volumes remained significantly larger in patients.Conclusions. High-functioning children with ASD showed a global increase in gray-matter, but not white-matter and cerebellar volume, proportional to the increase in brain volume, and a disproportional increase in ventricular volumes, still present after correction for brain volume. Advanced pubertal development in the patients compared to the age-matched controls may have contributed to the findings reported in the present study.

scholarly journals Predicting Receptive–Expressive Vocabulary Discrepancies in Preschool Children With Autism Spectrum Disorder

2018 ◽  
Vol 61 (6) ◽  
pp. 1426-1439 ◽  
Author(s):  
Jena McDaniel ◽  
Paul Yoder ◽  
Tiffany Woynaroski ◽  
Linda R. Watson
Keyword(s):  
Autism Spectrum Disorder ◽  
Language Development ◽  
Motor Performance ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Expressive Vocabulary ◽  
Vocabulary Size ◽  
Oral Motor ◽  
Children With Asd ◽  
Size Discrepancy

PurposeCorrelates of receptive–expressive vocabulary size discrepancies may provide insights into why language development in children with autism spectrum disorder (ASD) deviates from typical language development and ultimately improve intervention outcomes.MethodWe indexed receptive–expressive vocabulary size discrepancies of 65 initially preverbal children with ASD (20–48 months) to a comparison sample from the MacArthur–Bates Communicative Development Inventories Wordbank (Frank, Braginsky, Yurovsky, & Marchman, 2017) to quantify typicality. We then tested whether attention toward a speaker and oral motor performance predict typicality of the discrepancy 8 months later.ResultsAttention toward a speaker correlated positively with receptive–expressive vocabulary size discrepancy typicality. Imitative and nonimitative oral motor performance were not significant predictors of vocabulary size discrepancy typicality. Secondary analyses indicated that midpoint receptive vocabulary size mediated the association between initial attention toward a speaker and end point receptive–expressive vocabulary size discrepancy typicality.ConclusionsFindings support the hypothesis that variation in attention toward a speaker might partially explain receptive–expressive vocabulary size discrepancy magnitude in children with ASD. Results are consistent with an input-processing deficit explanation of language impairment in this clinical population. Future studies should test whether attention toward a speaker is malleable and causally related to receptive–expressive discrepancies in children with ASD.

scholarly journals Creative Yoga Intervention Improves Motor and Imitation Skills of Children With Autism Spectrum Disorder

2019 ◽  
Vol 99 (11) ◽  
pp. 1520-1534 ◽  
Author(s):  
Maninderjit Kaur ◽  
Anjana Bhat
Keyword(s):  
Autism Spectrum Disorder ◽  
Motor Performance ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Fine Motor ◽  
Children With Asd ◽  
Yoga Group ◽  
Fine Motor Performance ◽  
Academic Group

Abstract Background There is growing evidence for motor impairments in children with autism spectrum disorder (ASD), including poor gross and fine motor performance, poor balance, and incoordination. However, there is limited evidence on the effects of motor interventions for this population. Objective In the present study, the effects of a physical therapy intervention using creative yoga on the motor and imitation skills of children with ASD were evaluated. Design This study had a pretest-posttest control group design. Methods Twenty-four children with ASD aged between 5 and 13 years received 8 weeks of a physical therapist-delivered yoga or academic intervention. Children were tested before and after the intervention using a standardized motor measure, the Bruininks-Oseretsky Test of Motor Performance–2nd Edition (BOT-2). The imitation skills of children using familiar training-specific actions (ie, poses for the yoga group and building actions for the academic group) were also assessed. Results After the intervention, children in the yoga group improved gross motor performance on the BOT-2 and displayed fewer imitation/praxis errors when copying training-specific yoga poses. In contrast, children in the academic group improved their fine motor performance on the BOT-2 and performed fewer imitation errors while completing the training-specific building actions. Limitations The study limitations include small sample size and lack of long-term follow-up. Conclusions Overall, creative interventions, such as yoga, are promising tools for enhancing the motor and imitation skills of children with ASD.

scholarly journals The Effects of Rhythm and Robotic Interventions on the Imitation/Praxis, Interpersonal Synchrony, and Motor Performance of Children with Autism Spectrum Disorder (ASD): A Pilot Randomized Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Sudha M. Srinivasan ◽  
Maninderjit Kaur ◽  
Isabel K. Park ◽  
Timothy D. Gifford ◽  
Kerry L. Marsh ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Motor Performance ◽  
Standardized Test ◽  
Controlled Trial ◽  
Standard Of Care ◽  
Children With Autism ◽  
Autism Spectrum ◽  
The Body ◽  
Spectrum Disorder ◽  
Interpersonal Synchrony

We assessed the effects of three interventions, rhythm, robotic, and standard-of-care, on the imitation/praxis, interpersonal synchrony, and overall motor performance of 36 children with Autism Spectrum Disorder (ASD) between 5 and 12 years of age. Children were matched on age, level of functioning, and services received, prior to random assignment to one of the three groups. Training was provided for 8 weeks with 4 sessions provided each week. We assessed generalized changes in motor skills from the pretest to the posttest using a standardized test of motor performance, the Bruininks-Oseretsky Test of Motor Proficiency, 2nd edition (BOT-2). We also assessed training-specific changes in imitation/praxis and interpersonal synchrony during an early and a late session. Consistent with the training activities practiced, the rhythm and robot groups improved on the body coordination composite of the BOT-2, whereas the comparison group improved on the fine manual control composite of the BOT-2. All three groups demonstrated improvements in imitation/praxis. The rhythm and robot groups also showed improved interpersonal synchrony performance from the early to the late session. Overall, socially embedded movement-based contexts are valuable in promoting imitation/praxis, interpersonal synchrony, and motor performance and should be included within the standard-of-care treatment for children with ASD.

scholarly journals Reduced Frontal White Matter Volume in Long-Term Childhood Leukemia Survivors: A Voxel-Based Morphometry Study

2008 ◽  
Vol 29 (4) ◽  
pp. 792-797 ◽  
Author(s):  
M.E. Carey ◽  
M.W. Haut ◽  
S.L. Reminger ◽  
J.J. Hutter ◽  
R. Theilmann ◽  
...  
Keyword(s):  
White Matter ◽  
Childhood Leukemia ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Matter Volume ◽  
Frontal White Matter
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