Synthesis, Physicochemical Characterization and In vitro Evaluation of Biodegradable PLGA Nanoparticles entrapped to Folic acid for Targeted Delivery of Kaempferitrin

2022 ◽  
Author(s):  
Mydhili Govindarasu ◽  
Pari Abirami ◽  
Salman S. Alharthi ◽  
Muthu Thiruvengadam ◽  
Govindasamy Rajakumar ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vitro Evaluation

In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery

2010 ◽  
Vol 21 (5) ◽  
pp. 1587-1597 ◽  
Author(s):  
Sumanta K. Sahu ◽  
Sanjay K. Mallick ◽  
Susmita Santra ◽  
Tapas K. Maiti ◽  
Sudip K. Ghosh ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
In Vitro Evaluation

Quantum Dots CdSe/ZnS-Loaded Poly(D,L-Lactide-Co-Glycolide) Nanoparticles: Physicochemical Characterization and Application

2006 ◽  
Vol 505-507 ◽  
pp. 667-672 ◽  
Author(s):  
Chih Hui Yang ◽  
Kuo Chin Lin ◽  
Yu Huai Chang ◽  
Yu Cheng Lin
Keyword(s):  
Quantum Dots ◽  
Fluorescence Intensity ◽  
Fluorescence Spectra ◽  
Uv Light ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
Optimum Concentration ◽  
Cellular Internalization ◽  
Optimum Concentration Range

This paper described and characterized the quantum dots (QDs) with/without the polymeric PLGA applied in MC3T3E-1 delivery. Neat QDs were treated with various solvents, temperatures, exposure time and concentration to evaluate their stability and efficacy. We found that the intensity degree of fluorescence spectra (QDs) in different solvents follows the order: ether > THF > acetone > chloroform > methanol. Importantly, the QDs become inactive after 8-hr dissolution in the solvents of ether, THF or chloroform. According to this result, acetone and methanol are ideal solvents for QDs. The optimum concentration range of QDs in acetone is 5 to 10 mg/mL. We found that no obvious difference of fluorescence intensity was detected in QDs stored respectively at 4 °C, 24 °C and 44 °C (8-hour). When QDs were exposed to UV light (312 nm) for 2 hr, serious decay of fluorescence intensity was observed. In order to extend the application of QDs in medical areas, we encapsulated them in individual biocompatible poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles for in-vitro imaging of endocytosis in MC3T3E-1 cells. We demonstrated that the polymeric PLGA have the ability to permeate the cells for cellular internalization; the endocytotic activity could be enhanced by the polymeric QDs-encapsulated PLGA.

Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation

2020 ◽  
Vol 60 ◽  
pp. 102013 ◽  
Author(s):  
Sunny Shah ◽  
Dhanya Cristopher ◽  
Shweta Sharma ◽  
Moinuddin Soniwala ◽  
Jayant Chavda
Keyword(s):  
Plga Nanoparticles ◽  
Design Development ◽  
In Vitro Evaluation

Enhanced Cytotoxicity of Folic Acid-Targeted Liposomes Co-Loaded with C6 Ceramide and Doxorubicin: In Vitro Evaluation on HeLa, A2780-ADR, and H69-AR Cells

2016 ◽  
Vol 13 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Shravan Kumar Sriraman ◽  
Jiayi Pan ◽  
Can Sarisozen ◽  
Ed Luther ◽  
Vladimir Torchilin
Keyword(s):  
Folic Acid ◽  
In Vitro Evaluation ◽  
C6 Ceramide

Novel folate-targeted docetaxel-loaded nanoparticles for tumour targeting: in vitro and in vivo evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64306-64314 ◽  
Author(s):  
M. H. Han ◽  
Z. T. Li ◽  
D. D. Bi ◽  
Y. F. Guo ◽  
H. X. Kuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Tumour Targeting ◽  
Breast Cancer Therapy ◽  
In Vivo Evaluation ◽  
Targeted Delivery System

Cholesterol-PEG1000-FA (folic acid) was synthesized as a stabilizer to encapsulate DTX, for the construction of a promising targeted delivery system for breast cancer therapy.

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