Maternal report of fever from cold or flu during early pregnancy and the risk for noncardiac birth defects, National Birth Defects Prevention Study, 1997-2011

Workers in various industries can be exposed to oil mists when oil-based fluids are aerosolized during work processes. Oil mists can be inhaled or deposited on the skin. Little research exists on the reproductive effects of oil mist exposure in pregnant workers. We aimed to investigate associations between occupational oil mist exposure in early pregnancy and a spectrum of birth defects using data from 22,011 case mothers and 8140 control mothers in the National Birth Defects Prevention Study. In total, 150 mothers were rated as exposed. Manufacturing jobs, particularly apparel manufacturing, comprised the largest groups of exposed mothers. Mothers of infants with septal heart defects (odds ratio (OR): 1.8, 95% confidence interval (CI): 1.0–3.3), and especially perimembranous ventricular septal defects (OR: 2.5, CI: 1.2–5.2), were more likely to be occupationally exposed to oil mists in early pregnancy than control mothers; and their rater-estimated cumulative exposure was more likely to be higher. This was the first U.S. study evaluating associations between oil mist exposure and a broad spectrum of birth defects. Our results are consistent with previous European studies, supporting a potential association between oil-based exposures and congenital heart defects. Further research is needed to evaluate the reproductive effects of occupational oil mist exposure.

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ADHD Medication Use During Pregnancy and Risk for Selected Birth Defects: National Birth Defects Prevention Study, 1998-2011

Journal of Attention Disorders ◽

10.1177/1087054718759753 ◽

2018 ◽

Vol 24 (3) ◽

pp. 479-489 ◽

Cited By ~ 6

Author(s):

Kayla N. Anderson ◽

Annelise C. Dutton ◽

Cheryl S. Broussard ◽

Sherry L. Farr ◽

Jennifer N. Lind ◽

...

Keyword(s):

Birth Defects ◽

Early Pregnancy ◽

Medication Use ◽

Population Based ◽

Adhd Medication ◽

Prevention Study ◽

Crude Odds Ratio ◽

Maternal Characteristics ◽

Limb Deficiency ◽

Control Study

Objective: The objective of this study was to examine the prevalence of, and maternal characteristics associated with, ADHD medication use before and during pregnancy, and associations between early pregnancy ADHD medication use and risk for 12 selected birth defects. Method: We used data from the National Birth Defects Prevention Study (1998-2011), a U.S. population–based case-control study examining risk factors for major structural birth defects. Results: There was an increase in ADHD medication use from 1998-1999 (0.2%) to 2010-2011 (0.5%; p < .001). Early pregnancy ADHD medication use was more commonly reported by mothers of infants/fetuses with gastroschisis (crude odds ratio [cOR]: 2.9, 95% confidence interval [CI] = [1.2, 6.9]), omphalocele (cOR: 4.0, 95% CI = [1.2, 13.6]), and transverse limb deficiency (cOR: 3.3, 95% CI = [1.1, 9.6]). Conclusion: ADHD medication use before and during pregnancy was rare, but the prevalence of use has increased over time. In this analysis, early pregnancy ADHD medication use was associated with three of 12 selected birth defects.

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Use of antihistamine medications during early pregnancy and selected birth defects: The National Birth Defects Prevention Study, 1997–2011

Birth Defects Research ◽

10.1002/bdr2.1749 ◽

2020 ◽

Vol 112 (16) ◽

pp. 1234-1252

Author(s):

Craig Hansen ◽

Tania A. Desrosiers ◽

Kathy Wisniewski ◽

Matthew J. Strickland ◽

Martha M. Werler ◽

...

Keyword(s):

Birth Defects ◽

Early Pregnancy ◽

Prevention Study

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Faculty Opinions recommendation of Use of proton-pump inhibitors in early pregnancy and the risk of birth defects.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7754958.8087057 ◽

2011 ◽

Author(s):

Alexander Ford

Keyword(s):

Birth Defects ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Early Pregnancy

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Demographic Characteristics, Care, and Outcomes for Children with Oral Clefts in Three States Using Participants from the National Birth Defects Prevention Study

The Cleft Palate-Craniofacial Journal ◽

10.1597/07-237.1 ◽

2009 ◽

Vol 46 (6) ◽

pp. 575-582 ◽

Cited By ~ 5

Author(s):

Peter Damiano ◽

Margaret Tyler ◽

Paul A. Romitti ◽

Charlotte Druschel ◽

April A. Austin ◽

...

Keyword(s):

Health Care ◽

New York ◽

Health Status ◽

Birth Defects ◽

Population Based ◽

Primary Objective ◽

Demographic Characteristics ◽

Prevention Study ◽

Care Needs ◽

Oral Clefts

Objective: The primary objective of this study was to evaluate whether there were differences in the characteristics and outcomes of care for children with oral clefts (OCs) among population-based samples in three states. Design: Data on the health status and on speech and esthetic outcomes were collected using structured telephone interviews conducted during 2005–2006 with mothers of children with OCs aged 2 to 7 in Arkansas, Iowa, and New York. Participants: Mothers of children born with nonsyndromic OCs on or after January 1, 1998, and on or before December 31, 2003, in Arkansas, Iowa, or New York. Subjects were identified through their participation in the ongoing National Birth Defects Prevention Study. Main Outcome Measures: Demographic characteristics, rating of cleft care, severity of condition, health status, esthetic outcomes, and speech problems were evaluated by state of residence. Results: Children with OCs from Arkansas were from lower income families, and their parents were less likely to be married. Children with OCs from Arkansas were more likely to have special health care needs and to require mental health care. Few differences were found across states in type of cleft, severity of cleft, or outcomes of cleft care. Conclusions: Combining results from population-based samples across multiple studies increases the variability of sample characteristics. Including multiple states can be an efficient way to learn more about the outcomes of medical care for less common conditions such as oral cleft.

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Maternal Smoking and Congenital Heart Defects, National Birth Defects Prevention Study, 1997-2011

The Journal of Pediatrics ◽

10.1016/j.jpeds.2021.09.005 ◽

2021 ◽

Author(s):

Elijah H. Bolin ◽

Yevgeniya Gokun ◽

Paul A. Romitti ◽

Sarah C. Tinker ◽

April D. Summers ◽

...

Keyword(s):

Birth Defects ◽

Congenital Heart Defects ◽

Maternal Smoking ◽

Congenital Heart ◽

Heart Defects ◽

Prevention Study

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Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997–2011

Occupational and Environmental Medicine ◽

10.1136/oemed-2021-107561 ◽

2021 ◽

pp. oemed-2021-107561

Author(s):

Miriam R Siegel ◽

Carissa M Rocheleau ◽

Kendra Broadwater ◽

Albeliz Santiago-Colón ◽

Candice Y Johnson ◽

...

Keyword(s):

Birth Defects ◽

Cleft Lip ◽

Population Based ◽

Small Samples ◽

Prevention Study ◽

Control Data ◽

Reproductive Effects ◽

Race Ethnicity ◽

Maternal Occupation ◽

Pregnancy And Birth

ObjectiveNail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investigated associations between selected birth defects and maternal occupation as a nail technician or hairdresser versus a non-cosmetology occupation during pregnancy.MethodsWe analysed population-based case–control data from the multisite National Birth Defects Prevention Study, 1997–2011. Cases were fetuses or infants with major structural birth defects; controls were live-born infants without major birth defects. Expert raters classified self-reported maternal jobs as nail technician, combination nail technician-hairdresser, hairdresser, other cosmetology work or non-cosmetology work. We used logistic regression to calculate adjusted ORs and 95% CIs for associations between occupation during pregnancy and birth defects, controlling for age, smoking, education and race/ethnicity.ResultsSixty-one mothers worked as nail technicians, 196 as hairdressers, 39 as combination nail technician-hairdressers and 42 810 as non-cosmetologists. The strongest associations among nail technicians included seven congenital heart defect (CHD) groups (ORs ranging from 2.7 to 3.5) and neural tube defects (OR=2.6, CI=0.8 to 8.4). Birth defects most strongly associated with hairdressing included anotia/microtia (OR=2.1, CI=0.6 to 6.9) and cleft lip with cleft palate (OR=2.0, CI=1.1 to 3.7). All oral cleft groups were associated with combination nail technician-hairdresser work (ORs ranging from 4.2 to 5.3).ConclusionsSmall samples resulted in wide CIs. Still, results suggest associations between maternal nail technician work during pregnancy and CHDs and between hairdressing work and oral clefts.

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Fish consumption prior to pregnancy and pregnancy outcomes in the National Birth Defects Prevention Study, 1997–2011

Public Health Nutrition ◽

10.1017/s1368980018002641 ◽

2018 ◽

Vol 22 (2) ◽

pp. 336-343

Author(s):

Renata H Benjamin ◽

Laura E Mitchell ◽

Mark A Canfield ◽

Adrienne T Hoyt ◽

Dejian Lai ◽

...

Keyword(s):

Preterm Birth ◽

Birth Defects ◽

Pregnancy Outcomes ◽

Fish Consumption ◽

Large Population ◽

Population Based ◽

Prevention Study ◽

Preparation Methods ◽

The Usa ◽

Early Preterm Birth

AbstractObjectiveTo evaluate the relationships between maternal fish consumption and pregnancy outcomes in a large, population-based sample of women in the USA.DesignWe collected average fish consumption prior to pregnancy using a modified version of the semi-quantitative Willett FFQ. We estimated adjusted OR (aOR) and 95 % CI for associations between different levels of fish consumption and preterm birth (<37 weeks), early preterm birth (<32 and <35 weeks) and small-for-gestational-age infants (SGA; <10th percentile).SettingThe National Birth Defects Prevention Study (NBDPS).SubjectsControl mother–infant pairs with estimated delivery dates between 1997 and 2011 (n 10 919).ResultsNo significant associations were observed between fish consumption and preterm birth or early preterm birth (aOR = 0·7–1·0 and 0·7–0·9, respectively). The odds of having an SGA infant were elevated (aOR = 2·1; 95 % CI 1·2, 3·4) among women with daily fish consumption compared with women consuming fish less than once per month. No associations were observed between other levels of fish consumption and SGA (aOR = 0·8–1·0).ConclusionsHigh intake of fish was associated with twofold higher odds of having an SGA infant, while moderate fish consumption prior to pregnancy was not associated with preterm or SGA. Our study, like many other studies in this area, lacked information regarding preparation methods and the specific types of fish consumed. Future studies should incorporate information on nutrient and contaminant contents, preparation methods and biomarkers to assess these relationships.

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