Amino acid neurotransmitter transporters: Structure, function, and molecular diversity

BioEssays ◽  
1993 ◽  
Vol 15 (5) ◽  
pp. 323-332 ◽  
Author(s):  
Janet A. Clark ◽  
Susan G. Amara
Keyword(s):  
Amino Acid ◽  
Structure Function ◽  
Molecular Diversity ◽  
Neurotransmitter Transporters

scholarly journals Erythrocytosis Secondary to Increased Oxygen Affinity of a Mutant Hemoglobin, Hemoglobin Kempsey

Blood ◽  
1968 ◽  
Vol 31 (5) ◽  
pp. 623-632 ◽  
Author(s):  
CON S. REED ◽  
ROGER HAMPSON ◽  
SUSAN GORDON ◽  
RICHARD T. JONES ◽  
MILES J. NOVY ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structure Function ◽  
Autosomal Dominant ◽  
Oxygen Affinity ◽  
Chemical Characterization ◽  
Single Amino Acid ◽  
Genetic Transmission ◽  
Australian Family ◽  
Abnormal Hemoglobin

Abstract An abnormal hemoglobin, termed hemoglobin Kempsey, was found in association with erythrocytosis in ten members of an Australian family. Genetic transmission fits an autosomal dominant pattern. Chemical characterization of hemoglobin Kempsey identified a single amino acid substitution, β99Asp→Asn. Properties of hemoglobin Kempsey include a marked increase in oxygen affinity, retention of the Bohr effect, and decreased heme-heme interaction. Possible structure-function relations of this and other abnormal hemoglobins associated with erythrocytosis are discussed.

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