Determination of estradiol valerate in pharmaceutical preparations and human serum by flow injection chemiluminescence

Luminescence ◽  
2012 ◽  
Vol 28 (3) ◽  
pp. 407-411 ◽  
Author(s):  
Wenwen Liu ◽  
Liangxiao Xie ◽  
Hongshuang Liu ◽  
Shichao Xu ◽  
Bingcheng Hu ◽  
...  
Keyword(s):  
Human Serum ◽  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Estradiol Valerate ◽  
Flow Injection Chemiluminescence

scholarly journals Determination of Picogram Levels of Roxithromycin in Pharmaceutical, Human Serum, and Urine by Flow-Injection Chemiluminescence

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Jiangman Liu ◽  
Huan Yang ◽  
Yun Zhang ◽  
Min Wu ◽  
Haixiang Zhao ◽  
...  
Keyword(s):  
Human Serum ◽  
Flow Injection ◽  
Limit Of Detection ◽  
Inhibitory Effect ◽  
Injection System ◽  
Relative Standard ◽  
Flow Injection System ◽  
Flow Injection Chemiluminescence ◽  
Serum And Urine

A sensitive chemiluminescence (CL) method, based on the inhibitory effect of roxithromycin (ROX) on the CL reaction between luminol and dissolved oxygen in a flow-injection system, was first proposed for the determination of ROX at picogram levels. The decrement of CL intensity was linearly proportional to the logarithm of ROX concentrations ranging from 0.1 to 100 pg mL-1, giving the limit of detection (LOD) of 0.03 pg mL-1 (3σ). At a flow rate of 2.0 mL min-1, a complete analytical procedure including sampling and washing could be performed within 0.5 min, with relative standard deviations (RSDs) of less than 5.0% (n=5). The proposed procedure was applied successfully to the determination of ROX in pharmaceutical, human serum, and urine with the recoveries ranging from 90.0 to 110.0%.

Flow injection-chemiluminescence determination of propranolol in pharmaceutical preparations

2003 ◽  
Vol 488 (1) ◽  
pp. 81-88 ◽  
Author(s):  
A Townshend ◽  
J.A Murillo Pulgarı́n ◽  
M.T Alañón Pardo
Keyword(s):  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Flow Injection Chemiluminescence

Sensitive determination of 2-methoxyestradiol in pharmaceutical preparations and serum samples using flow injection chemiluminescence

Luminescence ◽  
2013 ◽  
Vol 29 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Hanchun Yao ◽  
Min Zhang ◽  
Wenyuan Zeng ◽  
Xiaoying Zeng ◽  
Zhenzhong Zhang
Keyword(s):  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Serum Samples ◽  
Sensitive Determination ◽  
Flow Injection Chemiluminescence

Flow injection-chemiluminescence determination of puerarin in pharmaceutical preparations

2004 ◽  
Vol 36 (3) ◽  
pp. 587-592 ◽  
Author(s):  
Qunlin Zhang ◽  
Aung Myint ◽  
Lijuan Liu ◽  
Xuewu Ge ◽  
Hua Cui
Keyword(s):  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Flow Injection Chemiluminescence

scholarly journals Subnanogram Determination of Aniracetam in Pharmaceutical Preparations and Biofluids by Flow Injection Analysis with Chemiluminescence Detection Based on Its Enhancement of the Myoglobin-Luminol Reaction

2011 ◽  
Vol 94 (5) ◽  
pp. 1461-1466
Author(s):  
Shao Xiaodong ◽  
Li Ying ◽  
Li Fagen ◽  
Liu Yangqin ◽  
Song Zhenghua
Keyword(s):  
Flow Injection ◽  
Pharmaceutical Preparations ◽  
Serum Samples ◽  
Reaction Conditions ◽  
Whole Process ◽  
Optimum Reaction ◽  
Human Urine And Serum ◽  
Flow Injection Chemiluminescence ◽  
Urine And Serum

Abstract A novel flow injection chemiluminescence method with a myoglobin-luminol system is described for determining aniracetam. Myoglobin-bound aniracetam produced a complex that catalyzed the chemiluminescence reaction between luminol and myoglobin, leading to fast chemiluminescence. The chemiluminescence intensity in the presence of aniracetam was remarkably enhanced compared with that in the absence of aniracetam. Under the optimum reaction conditions the chemiluminescence increment produced was proportional to the concentration of aniracetam in the range of 0.1–1000.0 ng/mL (R2 = 0.9992), with a detection limit of 0.03 ng/mL (3δ). At a flow rate of 2.0 mL/min, the whole process, including sampling and washing, could be completed in 0.5 min, offering a sampling efficiency of 120/h; the RSD was less than 3.0% (n = 5). The method was satisfactory for determination of aniracetam in pharmaceutical preparations and human urine and serum samples. A possible mechanism of the reaction is also discussed.

Determination of Picogram Levels of Levodopa in Pharmaceutical Preparations and Biofluids by Flow-Injection Chemiluminescence

2014 ◽  
Vol 884-885 ◽  
pp. 566-569 ◽  
Author(s):  
Yun Zhang ◽  
Su Ya Gao
Keyword(s):  
Flow Injection ◽  
Limit Of Detection ◽  
Pharmaceutical Preparations ◽  
Human Saliva ◽  
Quenching Effect ◽  
Dopa Concentration ◽  
Flow Injection Chemiluminescence ◽  
First Time ◽  
Serum And Urine

An ultrasensitive method for determination of L-dopa at picogram levels by flow-injection chemiluminescence (FI-CL) as presented for the first time, based on the quenching effect of levodopa (L-dopa) on the luminol-lysozyme reaction. It was found that the decrement of CL intensity was linearly proportional to the logarithm of L-dopa concentration ranging from 3.0 to 7.0 × 103pg mL-1(R= 0.9967), with the limit of detection (LOD) of 1.0 pg mL-1(3σ). The proposed procedure was successfully applied to the determination of L-dopa in pharmaceutical preparations, human saliva, serum, and urine samples with the recoveries ranging from 96.7% to 104.3% and RSDs less than 4.0% (n= 5).

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