Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models

2014 ◽  
Vol 112 (1) ◽  
pp. 84-97 ◽  
Author(s):  
Lia Tescione ◽  
James Lambropoulos ◽  
Madhava Ram Paranandi ◽  
Helena Makagiansar ◽  
Thomas Ryll
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Design Principles ◽  
Bioreactor Design ◽  
Scale Down

Development of a scale down cell culture model using multivariate analysis as a qualification tool

2013 ◽  
Vol 30 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Valerie Liu Tsang ◽  
Angela X. Wang ◽  
Helena Yusuf-Makagiansar ◽  
Thomas Ryll
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Cell Culture Model ◽  
Culture Model ◽  
Scale Down

scholarly journals Equal mixing time enables scale‐down and optimisation of a CHO cell culture process using a shaken microbioreactor system

2021 ◽  
Author(s):  
Vincent Wiegmann ◽  
Richard A. Gardner ◽  
Daniel I. R. Spencer ◽  
Frank Baganz
Keyword(s):  
Cell Culture ◽  
Mixing Time ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Scale Down ◽  
Culture Process ◽  
Cho Cell Culture

Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development

2009 ◽  
Vol 102 (1) ◽  
pp. 148-160 ◽  
Author(s):  
Aaron Chen ◽  
Rajesh Chitta ◽  
David Chang ◽  
Ashraf Amanullah
Keyword(s):  
Cell Culture ◽  
Process Development ◽  
Cell Culture Process ◽  
Scale Down ◽  
Culture Process ◽  
Bioreactor System

Development and Qualification of a Cell Culture Scale‐Down Model

2019 ◽  
pp. 391-405
Author(s):  
Sarwat Khattak ◽  
Valerie Pferdeort
Keyword(s):  
Cell Culture ◽  
Scale Down ◽  
A Cell

Application of Multivariate Analysis toward Biotech Processes: Case Study of a Cell-Culture Unit Operation

2007 ◽  
Vol 23 (1) ◽  
pp. 61-67 ◽  
Author(s):  
A.O. Kirdar ◽  
J.S. Conner ◽  
J. Baclaski ◽  
A.S. Rathore
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Unit Operation ◽  
A Cell

Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability

2012 ◽  
Vol 28 (5) ◽  
pp. 1138-1151 ◽  
Author(s):  
Bhargavi Kondragunta ◽  
Bharat H. Joshi ◽  
Jing Han ◽  
Kurt A. Brorson ◽  
Raj K. Puri ◽  
...  
Keyword(s):  
Cell Culture ◽  
Scale Down

Studies of Protein Oxidation as a Product Quality Attribute on a Scale-Down Model for Cell Culture Process Development

2015 ◽  
Vol 69 (2) ◽  
pp. 236-247
Author(s):  
N. D. Lee ◽  
B. Kondragunta ◽  
S. Uplekar ◽  
J. Vallejos ◽  
A. Moreira ◽  
...  
Keyword(s):  
Cell Culture ◽  
Product Quality ◽  
Protein Oxidation ◽  
Process Development ◽  
Cell Culture Process ◽  
Quality Attribute ◽  
Scale Down ◽  
Culture Process ◽  
Product Quality Attribute

Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality

2017 ◽  
Vol 114 (7) ◽  
pp. 1448-1458 ◽  
Author(s):  
David Brühlmann ◽  
Michael Sokolov ◽  
Alessandro Butté ◽  
Markus Sauer ◽  
Jürgen Hemberger ◽  
...  
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Experimental Design ◽  
Product Quality ◽  
Culture Media ◽  
Biosimilar Product ◽  
Cell Culture Media ◽  
Media Supplements ◽  
Efficient Screening

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

2014 ◽  
Vol 31 (2) ◽  
pp. 566-577 ◽  
Author(s):  
Brandon Berry ◽  
Justin Moretto ◽  
Thomas Matthews ◽  
John Smelko ◽  
Kelly Wiltberger
Keyword(s):  
Cell Culture ◽  
Raman Spectroscopy ◽  
Multivariate Analysis ◽  
Predictive Modeling ◽  
Cho Cell ◽  
Cho Cell Culture ◽  
Culture Growth ◽  
Cell Culture Growth

scholarly journals Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

2013 ◽  
Vol 91 (11) ◽  
pp. 2265-2274 ◽  
Author(s):  
Alvin W. Nienow ◽  
William H. Scott ◽  
Christopher J. Hewitt ◽  
Colin R. Thomas ◽  
Gareth Lewis ◽  
...  
Keyword(s):  
Cell Culture ◽  
Product Quality ◽  
Animal Cell ◽  
Animal Cell Culture ◽  
Scale Down ◽  
The Impact ◽  
Stress Parameters
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