Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability

2012 ◽  
Vol 28 (5) ◽  
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Author(s):  
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Bharat H. Joshi ◽  
Jing Han ◽  
Kurt A. Brorson ◽  
Raj K. Puri ◽  
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Scale Down

scholarly journals Equal mixing time enables scale‐down and optimisation of a CHO cell culture process using a shaken microbioreactor system

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Richard A. Gardner ◽  
Daniel I. R. Spencer ◽  
Frank Baganz
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Cho Cell ◽  
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Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development

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pp. 148-160 ◽  
Author(s):  
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Rajesh Chitta ◽  
David Chang ◽  
Ashraf Amanullah
Keyword(s):  
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Scale Down ◽  
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Development and Qualification of a Cell Culture Scale‐Down Model

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Valerie Pferdeort
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Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models

2014 ◽  
Vol 112 (1) ◽  
pp. 84-97 ◽  
Author(s):  
Lia Tescione ◽  
James Lambropoulos ◽  
Madhava Ram Paranandi ◽  
Helena Makagiansar ◽  
Thomas Ryll
Keyword(s):  
Cell Culture ◽  
Multivariate Analysis ◽  
Design Principles ◽  
Bioreactor Design ◽  
Scale Down

Studies of Protein Oxidation as a Product Quality Attribute on a Scale-Down Model for Cell Culture Process Development

2015 ◽  
Vol 69 (2) ◽  
pp. 236-247
Author(s):  
N. D. Lee ◽  
B. Kondragunta ◽  
S. Uplekar ◽  
J. Vallejos ◽  
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Cell Culture Process ◽  
Quality Attribute ◽  
Scale Down ◽  
Culture Process ◽  
Product Quality Attribute

scholarly journals Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

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pp. 2265-2274 ◽  
Author(s):  
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William H. Scott ◽  
Christopher J. Hewitt ◽  
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Cell Culture ◽  
Product Quality ◽  
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Scale Down ◽  
The Impact ◽  
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Modeling industrial centrifugation of mammalian cell culture using a capillary based scale-down system

2011 ◽  
Vol 108 (5) ◽  
pp. 989-998 ◽  
Author(s):  
Matthew Westoby ◽  
Jameson K. Rogers ◽  
Ryan Haverstock ◽  
Jonathan Romero ◽  
John Pieracci
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scholarly journals A novel scale-down cell culture and imaging design for the mechanistic insight of cell colonisation within porous substrate

2017 ◽  
Vol 267 (2) ◽  
pp. 150-159 ◽  
Author(s):  
C.M. GABBOTT ◽  
Z.X. ZHOU ◽  
G.X. HAN ◽  
T. SUN
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Cell Culture ◽  
Porous Substrate ◽  
Mechanistic Insight ◽  
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Development of a scale down cell culture model using multivariate analysis as a qualification tool

2013 ◽  
Vol 30 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Valerie Liu Tsang ◽  
Angela X. Wang ◽  
Helena Yusuf-Makagiansar ◽  
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Keyword(s):  
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Multivariate Analysis ◽  
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A Systematic Approach for Scale-Down Model Development and Characterization of Commercial Cell Culture Processes

2006 ◽  
Vol 22 (3) ◽  
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Author(s):  
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Y. Hashimura ◽  
R. Pendleton ◽  
J. Harms ◽  
E. Collins ◽  
...  
Keyword(s):  
Cell Culture ◽  
Systematic Approach ◽  
Model Development ◽  
Scale Down
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