Multi‐omic profiling ­of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Daniel Ley; Ali Kazemi Seresht; Mikael Engmark; Olivera Magdenoska; Kristian Fog Nielsen; Helene Faustrup Kildegaard; Mikael Rørdam Andersen

doi:10.1002/bit.25652

Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Biotechnology and Bioengineering ◽

10.1002/bit.25652 ◽

2015 ◽

Vol 112 (11) ◽

pp. 2373-2387 ◽

Cited By ~ 14

Author(s):

Daniel Ley ◽

Ali Kazemi Seresht ◽

Mikael Engmark ◽

Olivera Magdenoska ◽

Kristian Fog Nielsen ◽

...

Keyword(s):

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Heterologous Protein ◽

Chinese Hamster ◽

Heterologous Protein Production ◽

Ovary Cell ◽

Metabolic Adaptation

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Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Biotechnology and Bioengineering ◽

10.1002/bit.26054 ◽

2016 ◽

Vol 113 (10) ◽

pp. 2304-2304

Keyword(s):

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Heterologous Protein ◽

Chinese Hamster ◽

Heterologous Protein Production ◽

Ovary Cell ◽

Metabolic Adaptation

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Understanding the intracellular effects of yeast extract on the enhancement of Fc-fusion protein production in Chinese hamster ovary cell culture

Applied Microbiology and Biotechnology ◽

10.1007/s00253-015-6789-5 ◽

2015 ◽

Vol 99 (20) ◽

pp. 8429-8440 ◽

Cited By ~ 5

Author(s):

Dongdong Hu ◽

Yating Sun ◽

Xuping Liu ◽

Jintao Liu ◽

Xintao Zhang ◽

...

Keyword(s):

Cell Culture ◽

Fusion Protein ◽

Chinese Hamster Ovary Cell ◽

Yeast Extract ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Chinese Hamster ◽

Ovary Cell ◽

Fc Fusion Protein

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Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant Chinese hamster ovary cell cultures differs among cell lines

Biotechnology and Bioengineering ◽

10.1002/1097-0290(20001020)70:2<167::aid-bit6>3.0.co;2-p ◽

2000 ◽

Vol 70 (2) ◽

pp. 167-175 ◽

Cited By ~ 47

Author(s):

Joon Soo Ryu ◽

Tae Kyung Kim ◽

Joo Young Chung ◽

Gyun Min Lee

Keyword(s):

Cell Lines ◽

Chinese Hamster Ovary Cell ◽

Cell Cultures ◽

Chinese Hamster Ovary ◽

Glycine Betaine ◽

Protein Production ◽

Chinese Hamster ◽

Ovary Cell ◽

Foreign Protein

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Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production

Current Opinion in Chemical Engineering ◽

10.1016/j.coche.2013.08.002 ◽

2013 ◽

Vol 2 (4) ◽

pp. 391-397 ◽

Cited By ~ 35

Author(s):

Soo Min Noh ◽

Madhavi Sathyamurthy ◽

Gyun Min Lee

Keyword(s):

Cell Lines ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Chinese Hamster ◽

Therapeutic Protein ◽

Ovary Cell

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Promoter methylation and transgene copy numbers predict unstable protein production in recombinant chinese hamster ovary cell lines

Biotechnology and Bioengineering ◽

10.1002/bit.23216 ◽

2011 ◽

Vol 108 (11) ◽

pp. 2670-2681 ◽

Cited By ~ 80

Author(s):

Andrea Osterlehner ◽

Silke Simmeth ◽

Ulrich Göpfert

Keyword(s):

Cell Lines ◽

Chinese Hamster Ovary Cell ◽

Promoter Methylation ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Chinese Hamster ◽

Ovary Cell ◽

Copy Numbers

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Membrane anchored protein production from spheroid, porous, and solid microcarrier chinese hamster ovary cell cultures

Biotechnology and Bioengineering ◽

10.1002/bit.260470507 ◽

1995 ◽

Vol 47 (5) ◽

pp. 550-556 ◽

Cited By ~ 4

Author(s):

M. L. Kennard ◽

J. M. Piret

Keyword(s):

Chinese Hamster Ovary Cell ◽

Cell Cultures ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Chinese Hamster ◽

Ovary Cell

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Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

Metabolic Engineering ◽

10.1016/j.ymben.2019.11.007 ◽

2020 ◽

Vol 57 ◽

pp. 203-216 ◽

Cited By ~ 4

Author(s):

James D. Budge ◽

Tanya J. Knight ◽

Jane Povey ◽

Joanne Roobol ◽

Ian R. Brown ◽

...

Keyword(s):

Lipid Metabolism ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Protein Production ◽

Chinese Hamster ◽

Ovary Cell ◽

Cell Lipid

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Optimization of heterologous protein production in Chinese hamster ovary cells under overexpression of spliced form of human X-box binding protein

BMC Biotechnology ◽

10.1186/1472-6750-14-26 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 15

Author(s):

Galina Gulis ◽

Kelly Cristina Rodrigues Simi ◽

Renata Rodrigues de Toledo ◽

Andrea Queiroz Maranhao ◽

Marcelo Macedo Brigido

Keyword(s):

Chinese Hamster Ovary ◽

Protein Production ◽

Heterologous Protein ◽

Binding Protein ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Heterologous Protein Production ◽

Ovary Cells

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Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)70068-4 ◽

1981 ◽

Vol 256 (2) ◽

pp. 926-932 ◽

Cited By ~ 2

Author(s):

T.J. Singh ◽

C. Roth ◽

M.M. Gottesman ◽

I.H. Pastan

Keyword(s):

Protein Kinase ◽

Cyclic Amp ◽

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Type I

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Isolation and characterization of a Chinese hamster ovary cell mutant with altered regulation of phosphatidylserine biosynthesis

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)47193-7 ◽

1989 ◽

Vol 264 (33) ◽

pp. 19887-19892

Author(s):

K Hasegawa ◽

O Kuge ◽

M Nishijima ◽

Y Akamatsu

Keyword(s):

Chinese Hamster Ovary Cell ◽

Chinese Hamster Ovary ◽

Chinese Hamster ◽

Ovary Cell ◽

Cell Mutant ◽

Isolation And Characterization ◽

Altered Regulation

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Multi‐omic profiling ­of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

Understanding the intracellular effects of yeast extract on the enhancement of Fc-fusion protein production in Chinese hamster ovary cell culture

Osmoprotective effect of glycine betaine on foreign protein production in hyperosmotic recombinant Chinese hamster ovary cell cultures differs among cell lines

Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production

Promoter methylation and transgene copy numbers predict unstable protein production in recombinant chinese hamster ovary cell lines

Membrane anchored protein production from spheroid, porous, and solid microcarrier chinese hamster ovary cell cultures

Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

Optimization of heterologous protein production in Chinese hamster ovary cells under overexpression of spliced form of human X-box binding protein

Characterization of cyclic AMP-resistant Chinese hamster ovary cell mutants lacking type I protein kinase.

Isolation and characterization of a Chinese hamster ovary cell mutant with altered regulation of phosphatidylserine biosynthesis

Multi‐omic profiling of EPO‐producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production