Transcriptome and proteome analysis of steady‐state in a perfusion CHO cell culture process

2019 ◽  
Vol 116 (8) ◽  
pp. 1959-1972 ◽  
Author(s):  
Vania Bertrand ◽  
Daniel J. Karst ◽  
Alessia Bachmann ◽  
Katia Cantalupo ◽  
Miroslav Soos ◽  
...  
Keyword(s):  
Cell Culture ◽  
Steady State ◽  
Proteome Analysis ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture

scholarly journals Reduction of charge variants by CHO cell culture process optimization

2020 ◽  
Vol 72 (2) ◽  
pp. 259-269 ◽  
Author(s):  
Zhibing Weng ◽  
Jian Jin ◽  
ChunHua Shao ◽  
Huazhong Li
Keyword(s):  
Cell Culture ◽  
Process Optimization ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture ◽  
Charge Variants

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

2009 ◽  
Vol 103 (4) ◽  
pp. 733-746 ◽  
Author(s):  
Zizhuo Xing ◽  
Brian M. Kenty ◽  
Zheng Jian Li ◽  
Steven S. Lee
Keyword(s):  
Cell Culture ◽  
Large Scale ◽  
Scale Up ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture

A multi‐faceted approach to analyzing glucose heat‐degradants and evaluating impact to a CHO cell culture process

AIChE Journal ◽  
2020 ◽  
Vol 66 (9) ◽  
Author(s):  
Brandon Moore ◽  
Chris Grinnell ◽  
Boris Boumajny ◽  
Rachel Chen ◽  
Ruth Frenkel ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture

Conversion of a CHO cell culture process from perfusion to fed-batch technology without altering product quality

2006 ◽  
Vol 123 (1) ◽  
pp. 106-116 ◽  
Author(s):  
F. Meuwly ◽  
U. Weber ◽  
T. Ziegler ◽  
A. Gervais ◽  
R. Mastrangeli ◽  
...  
Keyword(s):  
Cell Culture ◽  
Product Quality ◽  
Cell Culture Process ◽  
Fed Batch ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture

scholarly journals High throughput screening data for a case study of CHO cell culture process development

Data in Brief ◽  
2021 ◽  
pp. 107491
Author(s):  
Qin He ◽  
Jianlin Xu ◽  
Erik Vandermark ◽  
Jun Tian ◽  
Yueming Qian ◽  
...  
Keyword(s):  
Cell Culture ◽  
High Throughput ◽  
High Throughput Screening ◽  
Process Development ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture

Miniature Bioreactors for Rapid Bioprocess Development of Mammalian Cell Culture

2012 ◽  
Vol 59 (1) ◽  
Author(s):  
Mohd Helmi Sani ◽  
Frank Baganz
Keyword(s):  
Cell Culture ◽  
Mammalian Cell ◽  
Process Development ◽  
Mammalian Cell Culture ◽  
Small Scale ◽  
Cell Culture Process ◽  
Deep Wells ◽  
Working Volume ◽  
Culture Process ◽  
And Control

At present, there are a number of commercial small scale shaken systems available on the market with instrumented controllable microbioreactors such as Micro–24 Microreactor System (Pall Corporation, Port Washington, NY) and M2P Biolector, (M2P Labs GmbH, Aachen, Germany). The Micro–24 system is basically an orbital shaken 24–well plate that operates at working volume 3 – 7 mL with 24 independent reactors (deep wells, shaken and sparged) running simultaneously. Each reactor is designed as single use reactor that has the ability to continuously monitor and control the pH, DO and temperature. The reactor aeration is supplied by sparging air from gas feeds that can be controlled individually. Furthermore, pH can be controlled by gas sparging using either dilute ammonia or carbon dioxide directly into the culture medium through a membrane at the bottom of each reactor. Chen et al., (2009) evaluated the Micro–24 system for the mammalian cell culture process development and found the Micro–24 system is suitable as scaledown tool for cell culture application. The result showed that intra-well reproducibility, cell growth, metabolites profiles and protein titres were scalable with 2 L bioreactors.

scholarly journals Benchmarking of commercially available CHO cell culture media for antibody production

2015 ◽  
Vol 99 (11) ◽  
pp. 4645-4657 ◽  
Author(s):  
David Reinhart ◽  
Lukas Damjanovic ◽  
Christian Kaisermayer ◽  
Renate Kunert
Keyword(s):  
Cell Culture ◽  
Antibody Production ◽  
Culture Media ◽  
Cho Cell ◽  
Cell Culture Media ◽  
Cho Cell Culture
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