scholarly journals Single‐cell transcriptome analyses reveal heterogeneity in suspension cultures and clonal markers of CHO‐K1 cells

2020 ◽  
Author(s):  
Norichika Ogata ◽  
Akio Nishimura ◽  
Tomoko Matsuda ◽  
Michi Kubota ◽  
Takeshi Omasa
Keyword(s):  
Single Cell ◽  
Suspension Cultures ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single-Cell Transcriptome Analyses Reveal Taxol Resistant Subpopulations in Esophageal Squamous Cancer Cells

2017 ◽  
Vol 99 (2) ◽  
pp. E627-E628
Author(s):  
H. Wu ◽  
J. Yu ◽  
S. Chen ◽  
X. Zhang ◽  
L. Yang ◽  
...  
Keyword(s):  
Single Cell ◽  
Cancer Cells ◽  
Squamous Cancer ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome ◽  
Esophageal Squamous Cancer

scholarly journals Single-Cell Transcriptome Analyses Reveal Signals to Activate Dormant Neural Stem Cells

Cell ◽  
2015 ◽  
Vol 161 (5) ◽  
pp. 1175-1186 ◽  
Author(s):  
Yuping Luo ◽  
Volkan Coskun ◽  
Aibing Liang ◽  
Juehua Yu ◽  
Liming Cheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Single Cell ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

Single-Cell Transcriptome Analyses Reveal Endothelial Cell Heterogeneity in Tumors and Changes following Antiangiogenic Treatment

2018 ◽  
Vol 78 (9) ◽  
pp. 2370-2382 ◽  
Author(s):  
Qi Zhao ◽  
Alexandra Eichten ◽  
Asma Parveen ◽  
Christina Adler ◽  
Ying Huang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Single Cell ◽  
Cell Heterogeneity ◽  
Antiangiogenic Treatment ◽  
Endothelial Cell Heterogeneity ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

Abstract 103: Single Cell Transcriptome Analyses Reveal Novel Targets for Therapeutic Neovascularisation by Resident Endothelial Cells in the Heart

2019 ◽  
Vol 125 (Suppl_1) ◽  
Author(s):  
Ziwen Li ◽  
Emmanouil G Solomonidis ◽  
Rodger Duffin ◽  
Ross Dobie ◽  
Marlene S Mahalhaes ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Single Cell ◽  
Novel Targets ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

Single-cell Transcriptome Analyses Reveal Molecular Signals to Intrinsic and Acquired Paclitaxel Resistance in Esophageal Squamous Cancer Cells

2018 ◽  
Vol 420 ◽  
pp. 156-167 ◽  
Author(s):  
Hongjin Wu ◽  
Sean Chen ◽  
Juehua Yu ◽  
Ying Li ◽  
Xiao-yan Zhang ◽  
...  
Keyword(s):  
Single Cell ◽  
Cancer Cells ◽  
Paclitaxel Resistance ◽  
Squamous Cancer ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Molecular Signals ◽  
Single Cell Transcriptome ◽  
Esophageal Squamous Cancer

scholarly journals Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses

2019 ◽  
Vol 157 (6) ◽  
pp. 1556-1571.e5 ◽  
Author(s):  
Sin-Ting Lau ◽  
Zhixin Li ◽  
Frank Pui-Ling Lai ◽  
Kathy Nga-Chu Lui ◽  
Peng Li ◽  
...  
Keyword(s):  
Neural Crest ◽  
Single Cell ◽  
Hedgehog Signaling ◽  
Neural Crest Cells ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiangmei Zhang ◽  
Igor Mandric ◽  
Kevin H. Nguyen ◽  
Thao T. T. Nguyen ◽  
Matteo Pellegrini ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Single Cell ◽  
Retinal Ganglion ◽  
Es Cell ◽  
Bhlh Factors ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome ◽  
Bhlh Transcription Factors ◽  
The Impact

The developing retina expresses multiple bHLH transcription factors. Their precise functions and interactions in uncommitted retinal progenitors remain to be fully elucidated. Here, we investigate the roles of bHLH factors ATOH7 and Neurog2 in human ES cell-derived retinal organoids. Single cell transcriptome analyses identify three states of proliferating retinal progenitors: pre-neurogenic, neurogenic, and cell cycle-exiting progenitors. Each shows different expression profile of bHLH factors. The cell cycle-exiting progenitors feed into a postmitotic heterozygous neuroblast pool that gives rise to early born neuronal lineages. Elevating ATOH7 or Neurog2 expression accelerates the transition from the pre-neurogenic to the neurogenic state, and expands the exiting progenitor and neuroblast populations. In addition, ATOH7 and Neurog2 significantly, yet differentially, enhance retinal ganglion cell and cone photoreceptor production. Moreover, single cell transcriptome analyses reveal that ATOH7 and Neurog2 each assert positive autoregulation, and both suppress key bHLH factors associated with the pre-neurogenic and states and elevate bHLH factors expressed by exiting progenitors and differentiating neuroblasts. This study thus provides novel insight regarding how ATOH7 and Neurog2 impact human retinal progenitor behaviors and neuroblast fate choices.

Sign in / Sign up

Export Citation Format

Share Document