Promotion of mitochondrial biogenesis by synthetic 1,2‐ or 1,3‐digallates through activation of an energy sensing network

2022 ◽  
Author(s):  
Taegum Lee ◽  
Mi Kyoung Kim ◽  
Youhoon Chong
Keyword(s):  
Mitochondrial Biogenesis ◽  
Energy Sensing

Pyruvate induces mitochondrial biogenesis by a PGC-1 α-independent mechanism

2007 ◽  
Vol 292 (5) ◽  
pp. C1599-C1605 ◽  
Author(s):  
Leanne Wilson ◽  
Qing Yang ◽  
Joseph D. Szustakowski ◽  
P. Scott Gullicksen ◽  
Reza Halse
Keyword(s):  
Mitochondrial Biogenesis ◽  
Energy Demand ◽  
Mitochondrial Protein ◽  
Oxidative Capacity ◽  
Sodium Pyruvate ◽  
Mitochondrial Mass ◽  
Primary Myoblasts ◽  
Independent Mechanism ◽  
Energy Sensing ◽  
The Impact

Oxidative cells increase mitochondrial mass in response to stimuli such as changes in energy demand or cellular differentiation. This plasticity enables the cell to adapt dynamically to achieve the necessary oxidative capacity. However, the pathways involved in triggering mitochondrial biogenesis are poorly defined. The present study examines the impact of altering energy provision on mitochondrial biogenesis in muscle cells. C2C12 myoblasts were chronically treated with supraphysiological levels of sodium pyruvate for 72 h. Treated cells exhibited increased mitochondrial protein expression, basal respiratory rate, and maximal oxidative capacity. The increase in mitochondrial biogenesis was independent of increases in peroxisomal proliferator activator receptor-γ coactivator-1α (PGC-1α) and PGC-1β mRNA expression. To further assess whether PGC-1α expression was necessary for pyruvate action, cells were infected with adenovirus containing shRNA for PGC-1α before treatment with pyruvate. Despite a 70% reduction in PGC-1α mRNA, the effect of pyruvate was preserved. Furthermore, pyruvate induced mitochondrial biogenesis in primary myoblasts from PGC-1α null mice. These data suggest that regulation of mitochondrial biogenesis by pyruvate in myoblasts is independent of PGC-1α, suggesting the existence of a novel energy-sensing pathway regulating oxidative capacity.

miR-494 Regulates Mitochondrial Biogenesis and Thermogenesis through PGC1-? Signaling in Beige Adipocytes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1966-P
Author(s):  
MENGISTU LEMECHA ◽  
KATSUTARO MORINO ◽  
TAKESHI IMAMURA ◽  
HIROTAKA IWASAKI ◽  
NATSUKO OHASHI ◽  
...  
Keyword(s):  
Mitochondrial Biogenesis ◽  
Beige Adipocytes

Rapid Communication: Dietary selenium improves skeletal muscle mitochondrial biogenesis in young equine athletes

2017 ◽  
Vol 95 (9) ◽  
pp. 4078 ◽  
Author(s):  
S. H. White ◽  
S. Wohlgemuth ◽  
C. Li ◽  
L. K. Warren
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Biogenesis ◽  
Dietary Selenium ◽  
Rapid Communication

Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle

10.2741/2134 ◽  
2007 ◽  
Vol 12 (1) ◽  
pp. 1164 ◽  
Author(s):  
Ana Navarro
Keyword(s):  
Nitric Oxide ◽  
Mitochondrial Biogenesis ◽  
Ovarian Cycle
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