Accurate and simple determination of oxcarbazepine in human plasma and urine samples using switchable‐hydrophilicity solvent in GC–MS

2020 ◽  
Vol 34 (10) ◽  
Author(s):  
Sezin Erarpat ◽  
Süleyman Bodur ◽  
Merve Fırat Ayyıldız ◽  
Ömer Tahir Günkara ◽  
Fatih Erulaş ◽  
...  
Keyword(s):  
Human Plasma ◽  
Urine Samples ◽  
Human Plasma And Urine ◽  
Plasma And Urine Samples ◽  
Switchable Hydrophilicity Solvent

Dispersive suspended-solidified floating organic droplet microextraction of nonsteroidal anti-inflammatory drugs: comparison of suspended droplet-based and dispersive-based liquid-phase microextraction methods

RSC Advances ◽  
2015 ◽  
Vol 5 (129) ◽  
pp. 106574-106588 ◽  
Author(s):  
Behruz Barfi ◽  
Alireza Asghari ◽  
Maryam Rajabi ◽  
Nasim Mirkhani
Keyword(s):  
Liquid Phase ◽  
Human Plasma ◽  
Urine Samples ◽  
Liquid Phase Microextraction ◽  
Human Plasma And Urine ◽  
Plasma And Urine Samples ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Suspended Droplet

A dispersive suspended-solidified floating organic droplet microextraction method was developed for determination of some nonsteroidal anti-inflammatory drugs in human plasma and urine samples.

Stereoselective Determination of Ornidazole Enantiomers in Human Plasma and Urine Samples by Chiral LC: Application to Pharmacokinetic Study

2008 ◽  
Vol 67 (11-12) ◽  
pp. 875-881 ◽  
Author(s):  
Huan Wang ◽  
Yan Chen ◽  
Jia Zhou ◽  
Chen Ma ◽  
Yuancheng Chen ◽  
...  
Keyword(s):  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Urine Samples ◽  
Human Plasma And Urine ◽  
Plasma And Urine Samples ◽  
Chiral Lc

scholarly journals Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: An Application in Drug Monitoring

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5799
Author(s):  
Olga Maliszewska ◽  
Natalia Treder ◽  
IIona Olędzka ◽  
Piotr Kowalski ◽  
Natalia Miękus ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Human Plasma ◽  
Fluorescence Detection ◽  
Limit Of Detection ◽  
Solid Phase ◽  
Biological Fluids ◽  
Internal Standard ◽  
Urine Samples ◽  
Human Plasma And Urine ◽  
Plasma And Urine Samples

A new approach for the sensitive, robust and rapid determination of idarubicin (IDA) in human plasma and urine samples based on liquid chromatography with fluorescence detection (LC-FL) was developed. Satisfactory chromatographic separation of the analyte after solid-phase extraction (SPE) was performed on a Discovery HS C18 analytical column using a mixture of acetonitrile and 0.1% formic acid in water as the mobile phase in isocratic mode. IDA and daunorubicin hydrochloride used as an internal standard (I.S.) were monitored at the excitation and emission wavelengths of 487 and 547 nm, respectively. The method was validated according to the FDA and ICH guidelines. The linearity was confirmed in the range of 0.1–50 ng/mL and 0.25–200 ng/mL, while the limit of detection (LOD) was 0.05 and 0.125 ng/mL in plasma and urine samples, respectively. The developed LC-FL method was successfully applied for drug determinations in human plasma and urine after oral administration of IDA at a dose of 10 mg to a patient with highly advanced alveolar rhabdomyosarcoma (RMA). Moreover, the potential exposure to IDA present in both fluids for healthcare workers and the caregivers of patients has been evaluated. The present LC-FL method can be a useful tool in pharmacokinetic and clinical investigations, in the monitoring of chemotherapy containing IDA, as well as for sensitive and reliable IDA quantitation in biological fluids.

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