A Systematic Approach for Scale-Down Model Development and Characterization of Commercial Cell Culture Processes

2006 ◽  
Vol 22 (3) ◽  
pp. 696-703 ◽  
Author(s):  
F. Li ◽  
Y. Hashimura ◽  
R. Pendleton ◽  
J. Harms ◽  
E. Collins ◽  
...  
Keyword(s):  
Cell Culture ◽  
Systematic Approach ◽  
Model Development ◽  
Scale Down

APPLICATION OF AMBR15 MINIBIOREACTORS IN CHARACTERIZATION OF SUSPENSION MONOCLONAL ANTIBODY CHO-PRODUCER CELL CULTURE PROCESS BASED ON QBD PRINCIPLES

2021 ◽  
Vol 1 (19) ◽  
pp. 180-181
Author(s):  
A.N. Morozov ◽  
I.R. Yakhin
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Quality By Design ◽  
Systematic Approach ◽  
Cell Culture Process ◽  
Culture Process ◽  
Producer Cell

A systematic approach to characterizing the cell culture process of CHO-producers of monoclonal antibodies within the framework of the concept "Quality by design" (QbD) with the use of ambr15 mini-bioreactors (TAP Biosystems) is shown.

Systematic approach for the characterization of additive manufactured and injection molded short carbon fiber-reinforced polymers under tensile loading

2020 ◽  
Vol 62 (6) ◽  
pp. 561-567
Author(s):  
Patrick Striemann ◽  
Daniel Huelsbusch ◽  
Selim Mrzljak ◽  
Michael Niedermeier ◽  
Frank Walther
Keyword(s):  
Carbon Fiber ◽  
Systematic Approach ◽  
Tensile Loading ◽  
Fiber Reinforced Polymers ◽  
Carbon Fiber Reinforced Polymers ◽  
Reinforced Polymers ◽  
Short Carbon Fiber ◽  
Injection Molded ◽  
Short Carbon

Treatment system response to transient AOX (adsorbable organic halogen) loadings

1997 ◽  
Vol 35 (2-3) ◽  
pp. 85-91
Author(s):  
D. A. Barton ◽  
J. D. Woodruff ◽  
T. M. Bousquet ◽  
A. M. Parrish
Keyword(s):  
Paper Industry ◽  
Model Development ◽  
Operating Conditions ◽  
System Response ◽  
Additional Information ◽  
Organic Halogen ◽  
Aox Removal ◽  
Variable Operating Conditions ◽  
Plant Shutdown

If promulgated as proposed, effluent guidelines for the U.S. pulp and paper industry will impose average monthly and maximum daily numerical limits of discharged AOX (adsorbable organic halogen). At this time, it is unclear whether the maximum-day variability factor used to establish the proposed effluent guidelines will provide sufficient margin for mills to achieve compliance during periods of normal but variable operating conditions within the pulping and bleaching processes. Consequently, additional information is needed to relate transient AOX loadings with final AOX discharges. This paper presents a simplistic dynamic model of AOX decay during treatment. The model consists of hydraulic characterization of an activated sludge process and a first-order decay coefficient for AOX removal. Data for model development were acquired by frequent collection of influent and effluent samples at a bleach kraft mill during a bleach plant shutdown and startup sequence.

Design and Characterization of Biomimetic Kerateine Aerogel-Electrospun Polycaprolactone Scaffolds for Retinal Cell Culture

2021 ◽  
Author(s):  
Ziqian Zeng ◽  
Phuong T. Lam ◽  
Michael L. Robinson ◽  
Katia Del Rio-Tsonis ◽  
Justin M. Saul
Keyword(s):  
Cell Culture ◽  
Retinal Cell

Detection and Characterization of Endothelin in Transformed Human Osteoblast Cell Culture Medium

Endocrine ◽  
2000 ◽  
Vol 12 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Hing-Chung Lam ◽  
Jenn-Kuen Lee ◽  
Kwok-Hung Lai
Keyword(s):  
Cell Culture ◽  
Culture Medium ◽  
Human Osteoblast ◽  
Osteoblast Cell ◽  
Cell Culture Medium ◽  
Human Osteoblast Cell

scholarly journals Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

2015 ◽  
Vol 147 (2) ◽  
pp. 412-424 ◽  
Author(s):  
Rowena L. C. Sison-Young ◽  
Dimitra Mitsa ◽  
Rosalind E. Jenkins ◽  
David Mottram ◽  
Eliane Alexandre ◽  
...  
Keyword(s):  
Cell Culture ◽  
Single Cell ◽  
Significant Variation ◽  
Human Liver ◽  
Drug Disposition ◽  
Culture Models ◽  
Single Cell Culture ◽  
Cell Culture Models

scholarly journals Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development

2014 ◽  
Vol 111 (12) ◽  
pp. 2486-2498 ◽  
Author(s):  
Georgina Espuny Garcia del Real ◽  
Jim Davies ◽  
Daniel G. Bracewell
Keyword(s):  
High Throughput ◽  
Process Development ◽  
Scale Down

scholarly journals Equal mixing time enables scale‐down and optimisation of a CHO cell culture process using a shaken microbioreactor system

2021 ◽  
Author(s):  
Vincent Wiegmann ◽  
Richard A. Gardner ◽  
Daniel I. R. Spencer ◽  
Frank Baganz
Keyword(s):  
Cell Culture ◽  
Mixing Time ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Scale Down ◽  
Culture Process ◽  
Cho Cell Culture

Characterization of the impact of classical cell‐culture media on the response of electrochemical sensors

2021 ◽  
Author(s):  
Ayman Chmayssem ◽  
Lauriane Petit ◽  
Nicolas Verplanck ◽  
Véronique Mourier ◽  
Séverine Vignoud ◽  
...  
Keyword(s):  
Cell Culture ◽  
Electrochemical Sensors ◽  
Culture Media ◽  
Cell Culture Media ◽  
The Impact
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