Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality

2017 ◽  
Vol 33 (5) ◽  
pp. 1368-1380 ◽  
Author(s):  
Michael Sokolov ◽  
Jonathan Ritscher ◽  
Nicola MacKinnon ◽  
Jonathan Souquet ◽  
Hervé Broly ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Cell Culture Process ◽  
Process Understanding ◽  
Culture Process ◽  
Multivariate Prediction ◽  
The Relationship

Fermentanomics: Relating quality attributes of a monoclonal antibody to cell culture process variables and raw materials using multivariate data analysis

2015 ◽  
Vol 31 (6) ◽  
pp. 1586-1599 ◽  
Author(s):  
Anurag S. Rathore ◽  
Sumit Kumar Singh ◽  
Mili Pathak ◽  
Erik K. Read ◽  
Kurt A. Brorson ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Data Analysis ◽  
Multivariate Data Analysis ◽  
Raw Materials ◽  
Multivariate Data ◽  
Quality Attributes ◽  
Cell Culture Process ◽  
Process Variables ◽  
Culture Process

Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Nitin Agarwal ◽  
Alison Mason ◽  
Rahul Pradhan ◽  
Jan Kemper ◽  
Allen Bosley ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Kinetic Modeling ◽  
Process Parameters ◽  
Cell Culture Process ◽  
Culture Process

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

2016 ◽  
Vol 33 (1) ◽  
pp. 181-191 ◽  
Author(s):  
Michael Sokolov ◽  
Jonathan Ritscher ◽  
Nicola MacKinnon ◽  
Jean-Marc Bielser ◽  
David Brühlmann ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Development ◽  
Cell Culture Process ◽  
Culture Process

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

2014 ◽  
Vol 188 ◽  
pp. 88-96 ◽  
Author(s):  
Marija Ivarsson ◽  
Thomas K. Villiger ◽  
Massimo Morbidelli ◽  
Miroslav Soos
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Parameters ◽  
Cell Culture Process ◽  
Culture Process ◽  
The Impact

Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl‐drug conjugation process

2018 ◽  
Vol 34 (6) ◽  
pp. 1427-1437 ◽  
Author(s):  
Michael B. Hippach ◽  
Ian Schwartz ◽  
Jian Pei ◽  
Jimmy Huynh ◽  
Yasuaki Kawai ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Dissolved Oxygen ◽  
Cell Culture Process ◽  
Dissolved Oxygen Concentration ◽  
Cho Cell ◽  
Drug Conjugation ◽  
Culture Process ◽  
Antibody Productivity ◽  
Conjugation Process

Exploring the linkage between cell culture process parameters and downstream processing utilizing a plackett-burman design for a model monoclonal antibody

2016 ◽  
Vol 33 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Cyrus D. Agarabi ◽  
Brittany K. Chavez ◽  
Scott C. Lute ◽  
Erik K. Read ◽  
Sarah Rogstad ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Parameters ◽  
Downstream Processing ◽  
Cell Culture Process ◽  
Culture Process ◽  
Burman Design ◽  
Plackett Burman Design

APPLICATION OF AMBR15 MINIBIOREACTORS IN CHARACTERIZATION OF SUSPENSION MONOCLONAL ANTIBODY CHO-PRODUCER CELL CULTURE PROCESS BASED ON QBD PRINCIPLES

2021 ◽  
Vol 1 (19) ◽  
pp. 180-181
Author(s):  
A.N. Morozov ◽  
I.R. Yakhin
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Quality By Design ◽  
Systematic Approach ◽  
Cell Culture Process ◽  
Culture Process ◽  
Producer Cell

A systematic approach to characterizing the cell culture process of CHO-producers of monoclonal antibodies within the framework of the concept "Quality by design" (QbD) with the use of ambr15 mini-bioreactors (TAP Biosystems) is shown.

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