The association between use of statin or aspirin and pancreatic ductal adenocarcinoma: A nested case‐control study in a Korean nationwide cohort

ABSTRACT Background Previous studies have found that meat-derived mutagens increase, and vitamin C or E decrease, the risk of pancreatic cancer. Objective The aim of this study was to determine whether intake of vitamin C or E modulates the association between meat-derived mutagen exposure and risk of pancreatic cancer. Design We conducted a case-control study in 1321 patients with pathologically confirmed pancreatic ductal adenocarcinoma (PDAC) and 1061 healthy controls (aged 28–88 y). Cases and controls were frequency-matched by age, sex, and race/ethnicity. Mutagen intake was assessed using a meat preparation questionnaire. Intakes of vitamin C, E, and other dietary components were assessed via a food-frequency questionnaire in a subset of 811 cases and 818 controls. ORs and 95% CIs were estimated in multivariable-adjusted logistic regression models. Results The risk of PDAC was not associated with meat intake but was associated with consumption of well-done grilled or barbecued chicken (OR: 1.57; 95% CI: 1.18, 2.09; P = 0.001). Intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline was associated with increased PDAC risk (Ptrend = 0.047). Participants in the highest, as compared with the lowest, quintile of 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (PhIP) intake experienced a 38% increased risk of PDAC (95% CI: 1.00, 1.90; P = 0.048). Intakes of total vitamin C or E from food and supplements or from supplements alone were each inversely associated with PDAC risk. Stratified analyses showed differential associations for PhIP intake and PDAC risk, such that risk increased among individuals with lower intake of vitamin C or E and decreased among those with higher vitamin intake. Significant interactions of dietary vitamin C, dietary vitamin E, and total vitamin E with PhIP intake were detected (Pinteraction = 0.023, <0.001, and 0.013, respectively). Conclusions Consistent with experimental evidence, this study of 811 cases and 818 controls has shown that high intake of dietary vitamin C or E mitigates the risk of PhIP-related PDAC.

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Associations between metabolites and pancreatic cancer risk in a large prospective epidemiological study

Gut ◽

10.1136/gutjnl-2019-319811 ◽

2020 ◽

Vol 69 (11) ◽

pp. 2008-2015 ◽

Cited By ~ 1

Author(s):

Rachael Stolzenberg-Solomon ◽

Andriy Derkach ◽

Steven Moore ◽

Stephanie J Weinstein ◽

Demetrius Albanes ◽

...

Keyword(s):

Fixed Effects ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Case Control ◽

Ductal Adenocarcinoma ◽

Blood Collection ◽

Blood Draw ◽

Metabolite Level ◽

Nested Case Control ◽

Control Study

ObjectiveTo assess whether prediagnostic metabolites were associated with incident pancreatic ductal adenocarcinoma (PDAC) in a prospective cohort study.DesignWe conducted an untargeted analysis of 554 known metabolites measured in prediagnostic serum (up to 24 years) to determine their association with incident PDAC in a nested case-control study of male smokers (372 matched case-control sets) and an independent nested case-control study that included women and non-smokers (107 matched sets). Metabolites were measured using Orbitrap Elite or Q-Exactive high-resolution/accurate mass spectrometers. Controls were matched to cases by age, sex, race, date of blood draw, and follow-up time. We used conditional logistic regression adjusted for age to calculate ORs and 95% CIs for a 1 SD increase in log-metabolite level separately in each cohort and combined the two ORs using a fixed-effects meta-analysis.ResultsThirty-one metabolites were significantly associated with PDAC at a false discovery rate <0.05 with 12 metabolites below the Bonferroni-corrected threshold (p<9.04×10–5). Similar associations were observed in both cohorts. The dipeptides glycylvaline, aspartylphenylalanine, pyroglutamylglycine, phenylalanylphenylalanine, phenylalanylleucine and tryptophylglutamate and amino acids aspartate and glutamate were positively while the dipeptides tyrosylglutamine and α-glutamyltyrosine, fibrinogen cleavage peptide DSGEGDFXAEGGGVR and glutathione-related amino acid cysteine-glutathione disulfide were inversely associated with PDAC after Bonferroni correction. Five top metabolites demonstrated significant time-varying associations (p<0.023) with the strongest associations observed 10–15 years after participants’ blood collection and attenuated thereafter.ConclusionOur results suggest that prediagnostic metabolites related to subclinical disease, γ-glutamyl cycle metabolism and adiposity/insulin resistance are associated with PDAC.

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CT Abnormalities of the Pancreas Associated With the Subsequent Diagnosis of Clinical Stage I Pancreatic Ductal Adenocarcinoma More Than One Year Later: A Case-Control Study

American Journal of Roentgenology ◽

10.2214/ajr.21.26014 ◽

2021 ◽

Author(s):

Fumihito Toshima ◽

Ryosuke Watanabe ◽

Dai Inoue ◽

Norihide Yoneda ◽

Tatsuya Yamamoto ◽

...

Keyword(s):

Pancreatic Ductal Adenocarcinoma ◽

Case Control Study ◽

Clinical Stage ◽

Case Control ◽

Stage I ◽

Ductal Adenocarcinoma ◽

One Year ◽

Control Study

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AB088. P060. Safety assessment of standardized pancreatectomy in patients with solid pseudopapillary tumor and pancreatic ductal adenocarcinoma: retrospective case-control study in a single center

Annals of Pancreatic Cancer ◽

10.21037/apc.2018.ab088 ◽

2018 ◽

Vol 1 (1) ◽

pp. AB088-AB088

Author(s):

Peng Wang ◽

Jishu Wei ◽

Kai Zhang ◽

Qiuyang Chen ◽

Tongtai Liu ◽

...

Keyword(s):

Pancreatic Ductal Adenocarcinoma ◽

Safety Assessment ◽

Case Control Study ◽

Case Control ◽

Ductal Adenocarcinoma ◽

Solid Pseudopapillary Tumor ◽

Single Center ◽

Retrospective Case ◽

Control Study

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Central pancreatectomy for early-stage pancreatic ductal adenocarcinoma: a single-center case–control study

Langenbeck s Archives of Surgery ◽

10.1007/s00423-019-01766-1 ◽

2019 ◽

Vol 404 (2) ◽

pp. 175-182 ◽

Cited By ~ 2

Author(s):

Hao Gao ◽

Tongtai Liu ◽

Guangfu Wang ◽

Yong Gao ◽

Lingdi Yin ◽

...

Keyword(s):

Pancreatic Ductal Adenocarcinoma ◽

Case Control Study ◽

Early Stage ◽

Case Control ◽

Ductal Adenocarcinoma ◽

Central Pancreatectomy ◽

Single Center ◽

Control Study

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Identification of symptoms associated with the diagnosis of pancreatic exocrine and neuroendocrine neoplasms: a nested case-control study of the UK population

British Journal of General Practice ◽

10.3399/bjgp.2021.0153 ◽

2021 ◽

pp. BJGP.2021.0153

Author(s):

Weiqi Liao ◽

Ashley Kieran Clift ◽

Martina Patone ◽

Carol Coupland ◽

Arturo González-Izquierdo ◽

...

Keyword(s):

Case Control Study ◽

Conditional Logistic Regression ◽

Stage Iv ◽

Case Control ◽

Ductal Adenocarcinoma ◽

Incidence Density ◽

Neuroendocrine Neoplasms ◽

Dark Urine ◽

Nested Case Control ◽

Control Study

Background: Pancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients were diagnosed at Stage IV. Aim: This study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (PDAC) and neuroendocrine neoplasms (PNEN), comparatively characterise the symptomatology between the two tumour types to inform earlier diagnosis. Design and Setting: A nested case-control study was conducted using data from the QResearch database. Patients aged ≥25 years and diagnosed with PDAC or PNEN during 2000-2019 were the cases. Up to 10 controls from the same general practice were matched with each case by age, sex, and calendar year using incidence density sampling. Methods: Conditional logistic regression was used to investigate the association between the forty-two shortlisted symptoms and the diagnoses of PDAC/PNEN in different timeframes relative to the index date, adjusting for patients’ sociodemographic characteristics, lifestyle, and relevant comorbidities. Results: There were 23,640 patients diagnosed with PDAC and 596 with PNEN. Twenty-three symptoms were significantly associated with PDAC, and nine symptoms with PNEN. Jaundice and gastrointestinal bleeding were the two alarm symptoms for both tumours. Thirst and dark urine were the two new identified symptoms for PDAC. The risk of unintentional weight loss may be longer than two years before the diagnosis of PNEN. Conclusion: PDAC and PNEN have overlapping symptom profiles. The QCancer (Pancreas) risk prediction model could be updated by including the newly identified symptoms and comorbidities, which could help GP identify high-risk patients for timely investigation in primary care.

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