scholarly journals Lymph node metastases >5 and metastatic lymph node ratio >0.30 of differentiated thyroid cancer predict response to radioactive iodine

2021 ◽  
Author(s):  
Canhua Yun ◽  
Juan Xiao ◽  
Jingjia Cao ◽  
Chunchun Shao ◽  
Lihua Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Differentiated Thyroid Cancer ◽  
Lymph Node Ratio ◽  
Radioactive Iodine ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Node Metastases

Metastatic lymph node ratio is a more precise predictor of prognosis than number of lymph node metastases in stage III colon cancer

2009 ◽  
Vol 24 (11) ◽  
pp. 1297-1302 ◽  
Author(s):  
Chih-Chien Chin ◽  
Jeng-Yi Wang ◽  
Chien-Yuh Yeh ◽  
Yi-Hung Kuo ◽  
Wen-Shih Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Node Metastases

Metastatic Lymph Node Ratio in Papillary Thyroid Cancer Does Not Affect Survival

2015 ◽  
Vol 221 (4) ◽  
pp. S61
Author(s):  
Paritosh Suman ◽  
Richard A. Prinz ◽  
Edward Wang ◽  
Tricia A. Moo-Young
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Papillary Thyroid ◽  
Metastatic Lymph ◽  
Node Ratio

scholarly journals Metastatic lymph node ratio can further stratify risk for mortality in medullary thyroid cancer patients: A population-based analysis

Oncotarget ◽  
2016 ◽  
Vol 7 (40) ◽  
pp. 65937-65945 ◽  
Author(s):  
Ning Qu ◽  
Rong-liang Shi ◽  
Zhong-wu Lu ◽  
Tian Liao ◽  
Duo Wen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Medullary Thyroid Cancer ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Population Based ◽  
Medullary Thyroid ◽  
Metastatic Lymph ◽  
Node Ratio

scholarly journals Does Metastatic Lymph Node Ratio Really Suit for Prognostic Prediction of the D1 Lymphadenectomy?

2010 ◽  
Vol 17 (6) ◽  
pp. 1718-1718 ◽  
Author(s):  
Jingyu Deng ◽  
Han Liang
Keyword(s):  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Prognostic Prediction

236 Evaluation of PD-L1 expression in primary lung tumor and metastatic lymph nodes in the presence of immune cells

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A253-A253
Author(s):  
Chris Hansis ◽  
Xiaomei Wang ◽  
Tao Wang ◽  
Gerald Feldman
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Immune Cells ◽  
Lymph Node Metastases ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph ◽  
Node Metastases

BackgroundImmunotherapies against programmed death ligand-1 (PD-L1) have been established as an effective treatment for a subset of lung cancer patients. Even though it is critical for a successful therapy to know prevalent PD-L1 expression patterns in all affected tissues, information on matching lymph node metastases and immune cells is particularly limited. The purpose of this study was thus to evaluate comparative PD-L1 expression profiles in those tissues.MethodsFDA-approved IHC assays for PD-L1 (Dako 22C3) were performed on a lung tissue array (LC814A, US Biomax) according to manufacturer’s instructions. Histopathological analysis by H-scoring was performed to determine the rate and intensity of positive tumor and immune cell staining for each of the 80 cores. The H score was calculated as follows: A total of up to 300 cells were assessed, per specimen, at 40x high-power magnification (typically over 7–10 fields). A staining level of 0–3 was then assigned to each cell, to designate the intensity of specific positive membranous-to-cytoplasmic staining. The H score was subsequently calculated as% cells staining at level 1 (x1) +% cells staining at level 2 (x2) +% cells staining at level 3 (x3) = total H score per sample. This resulted in a maximum possible H score of 300.ResultsOf the 16 adenocarcinoma tumor samples with a valid staining, 7 (44%) showed positive PD-L1 staining for tumor cells and 10 (63%) for primary immune cells. Importantly, 9 matching metastatic lymph node samples out of the 16 samples (56%) showed an increased PD-L1 H score compared to primary tumors for both tumor cells and immune cells (figure 1). Of the 15 squamous cell carcinoma samples with a valid staining, 11 (73%) showed detectable PD-L1 expression levels in the primary tumor and 12 (80%) in the primary immune cells, while 7 (47%) and 9 (60%) showed lower scores in matching metastatic lymph node tumor cells and their immune cells, respectively (figure 2). Very low or no expression of PD-L1 was detected in small cell lung cancer, as to be expected from previous studies.Abstract 236 Figure 1PD-L1 Staining in adenocarcinomaAbstract 236 Figure 2PD-L1 Staining in squamous cell carcinomaConclusionsSquamous cell carcinomas and adenocarcinomas display significant heterogeneity with regard to PD-L1 expression in associated lymph node metastases. While the reasons for this frequent discordant PD-L1 expression pattern involving both tumor and immune cells need to be investigated further, our findings may help guide the proper interpretation of PD-L1 companion diagnostic test results and subsequent therapeutic decisions.AcknowledgementsThe views in this Abstract have not been formally disseminated by the U.S. Food and Drug Administration and should not be construed to represent any agency determination or policy.

Prognostic significance of the metastatic lymph node ratio compared to the TNM classification in stage III gastric cancer

2021 ◽  
Vol 24 (11) ◽  
pp. 1602
Author(s):  
S Gulmez ◽  
AS Senger ◽  
O Uzun ◽  
S Omeroglu ◽  
C Ofluoglu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Tnm Classification ◽  
Prognostic Significance ◽  
Stage Iii ◽  
Metastatic Lymph ◽  
Node Ratio

Prognostic Significance of the Metastatic Lymph Node Ratio in Gastric Cancer Patients

2009 ◽  
Vol 33 (11) ◽  
pp. 2378-2382 ◽  
Author(s):  
Naoto Fukuda ◽  
Yasuyuki Sugiyama ◽  
Akira Midorikawa ◽  
Hiroyuki Mushiake
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Gastric Cancer Patients

Prognostic Significance of Metastatic Lymph Node Ratio in Node-Positive Colon Carcinoma

2007 ◽  
Vol 14 (5) ◽  
pp. 1712-1717 ◽  
Author(s):  
Ho-Young Lee ◽  
Hong-Jo Choi ◽  
Ki-Jae Park ◽  
Jong-Sok Shin ◽  
Hyuk-Chan Kwon ◽  
...  
Keyword(s):  
Lymph Node ◽  
Colon Carcinoma ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Prognostic Significance ◽  
Node Positive ◽  
Metastatic Lymph ◽  
Node Ratio

Impact of Metastatic Lymph Node to Total Lymph Node Ratio on Survival of Endometrial Cancer Patients

2019 ◽  
Vol 84 (5) ◽  
pp. 463-471 ◽  
Author(s):  
Siriwan Tangjitgamol ◽  
Thannaporn Kittisiam ◽  
Jittrind Sriraumpuch
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Metastatic Lymph Node ◽  
Metastatic Lymph ◽  
Node Ratio ◽  
Total Lymph Node
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