PD‐L1 expression is associated with the spontaneous regression of patients with methotrexate‐associated lymphoproliferative disorders

Lymphoid cells were analyzed within pulmonary infiltrates of six patients with lymphoproliferative disorders involving lungs by immunofluorescence and immunoperoxidase techniques utilizing monoclonal antibodies to cell surface antigens T11 (total T), T4 (inducer/helper T), T8 (cytotoxic/suppressor T) and B1 (B cells) and the antisera against heavy (G,A,M) and light (kappa, lambda) immunoglobulin chains. Three patients had pseudolymphoma, two patients had lymphoma and one patient had lymphomatoid granulomatosis.A mixed population of cells was present in tissue infiltrates from the three patients with pseudolymphoma, IgM-kappa producing cells constituted the main B cell type in one patient. In two patients with lymphoma pattern the infiltrates were composed exclusively of T4+ cells and IgG-lambda B cells predominated slightly in the patient with lymphomatoid granulomatosis.

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Spontaneous regression of plane warts after inflammation: clinical and histologic studies in 25 cases

Archives of Dermatology ◽

10.1001/archderm.113.9.1209 ◽

1977 ◽

Vol 113 (9) ◽

pp. 1209-1213 ◽

Cited By ~ 20

Author(s):

H. Tagami

Keyword(s):

Spontaneous Regression

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Multicentric bowen's disease of the genitalia: spontaneous regression of lesions

Archives of Dermatology ◽

10.1001/archderm.114.11.1698 ◽

1978 ◽

Vol 114 (11) ◽

pp. 1698-1699 ◽

Cited By ~ 11

Author(s):

B. W. Berger

Keyword(s):

Spontaneous Regression ◽

Bowen’S Disease ◽

Bowen's Disease

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Lasertechniques treatment of vascular malformations

Phlebologie ◽

10.1055/s-0037-1622304 ◽

2010 ◽

Vol 39 (03) ◽

pp. 167-175

Author(s):

M. Poetke ◽

P. Urban ◽

H.-P. Berlien

Keyword(s):

Endothelial Cells ◽

Spontaneous Regression ◽

Vascular System ◽

Vascular Malformations ◽

Clinical Importance ◽

Vascular Structure ◽

Laser Application ◽

Vascular Morphogenesis ◽

Structural Abnormalities

SummaryVascular malformations are structural abnormalities, errors of vascular morphogenesis, which can be localized in all parts of the vascular system. All vascular malformations by definition, are present at birth and grow proportionately with the child; their volume can change. In contrast to the haemangiomas, which only proliferate from the endothelial cells the division in stages is of clinical importance. Vascular malformations are divided from the part of vascular system, which is affected.In principle the techniques of laser application in congenital vascular tumours like haemangiomas and in vascular malformations are similar, but the aim is different. In tumours the aim is to induce regression, in vascular malformations the aim is to destroy the pathologic vascular structure because there is no spontaneous regression. This means that the parameters for treatment of vascular malformations must be more aggressive than for vascular tumours.

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