scholarly journals Increased valency improves inhibitory activity of peptides targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)

ChemBioChem ◽  
2021 ◽  
Author(s):  
Benjamin J. Tombling ◽  
Carmen Lammi ◽  
Carlotta Bollati ◽  
Anna Anoldi ◽  
David Craik ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Proprotein Convertase

Dammarane-type saponins with proprotein convertase subtilisin/kexin type 9 inhibitory activity from Gynostemma pentaphyllum

2022 ◽  
Vol 194 ◽  
pp. 113005
Author(s):  
Ya-Ping Huang ◽  
Yun-Shan Wang ◽  
Bi-Wen Liu ◽  
Zhe Song ◽  
Xiao-Shuang Liang ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Proprotein Convertase ◽  
Gynostemma Pentaphyllum

A stilbene dimer and flavonoids from the aerial parts of Chromolaena odorata with proprotein convertase subtilisin/kexin type 9 expression inhibitory activity

2020 ◽  
Vol 99 ◽  
pp. 103869
Author(s):  
Pisey Pel ◽  
Hee-Sung Chae ◽  
Piseth Nhoek ◽  
Young-Mi Kim ◽  
Piseth Khiev ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Chromolaena Odorata ◽  
Proprotein Convertase ◽  
Aerial Parts

scholarly journals Polyphenols with indirect proprotein convertase inhibitory activity

2013 ◽  
Vol 43 (3) ◽  
pp. 947-955 ◽  
Author(s):  
JINGJING ZHU ◽  
WIM VAN DE VEN ◽  
ALPHONS VERMORKEN
Keyword(s):  
Inhibitory Activity ◽  
Proprotein Convertase

Inhibitory Activity and Structural Characterization of a C-Terminal Peptide Fragment Derived from the Prosegment of the Proprotein Convertase PC7†

Biochemistry ◽  
2000 ◽  
Vol 39 (11) ◽  
pp. 2868-2877 ◽  
Author(s):  
Surajit Bhattacharjya ◽  
Ping Xu ◽  
Mei Zhong ◽  
Michel Chrétien ◽  
Nabil G. Seidah ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Inhibitory Activity ◽  
Peptide Fragment ◽  
Proprotein Convertase

Inhibitory effects of bioaccessible anthocyanins and procyanidins from apple, red grape, cinnamon on α-amylase, α-glucosidase and lipase

2020 ◽  
pp. 1-9
Author(s):  
Pınar Ercan ◽  
Sedef Nehir El
Keyword(s):  
Inhibitory Activity ◽  
Digestive Enzymes ◽  
Positive Control ◽  
Anthocyanin Content ◽  
Inhibitory Effects ◽  
Total Anthocyanin ◽  
Total Anthocyanin Content ◽  
Before And After ◽  
Red Grape

Abstract. The goals of this study were to determine and evaluate the bioaccessibility of total anthocyanin and procyanidin in apple (Amasya, Malus communis), red grape (Papazkarası, Vitis vinifera) and cinnamon (Cassia, Cinnamomum) using an in vitro static digestion system based on human gastrointestinal physiologically relevant conditions. Also, in vitro inhibitory effects of these foods on lipid (lipase) and carbohydrate digestive enzymes (α-amylase and α-glucosidase) were performed with before and after digested samples using acarbose and methylumbelliferyl oleate (4MUO) as the positive control. While the highest total anthocyanin content was found in red grape (164 ± 2.51 mg/100 g), the highest procyanidin content was found in cinnamon (6432 ± 177.31 mg/100 g) (p < 0.05). The anthocyanin bioaccessibilities were found as 10.2 ± 1%, 8.23 ± 0.64%, and 8.73 ± 0.70% in apple, red grape, and cinnamon, respectively. The procyanidin bioaccessibilities of apple, red grape, and cinnamon were found as 17.57 ± 0.71%, 14.08 ± 0.74% and 18.75 ± 1.49%, respectively. The analyzed apple, red grape and cinnamon showed the inhibitory activity against α-glucosidase (IC50 544 ± 21.94, 445 ± 15.67, 1592 ± 17.58 μg/mL, respectively), α-amylase (IC50 38.4 ± 7.26, 56.1 ± 3.60, 3.54 ± 0.86 μg/mL, respectively), and lipase (IC50 52.7 ± 2.05, 581 ± 54.14, 49.6 ± 2.72 μg/mL), respectively. According to our results apple, red grape and cinnamon have potential to inhibit of lipase, α-amylase and α-glucosidase digestive enzymes.

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal
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