Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Alexander Schuppe ◽  
Yizhou Zhao ◽  
Yannan Liu
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Knoevenagel Condensation ◽  
Cost Effective ◽  
Effective Procedure ◽  
Direct Transformation ◽  
Structural Revision ◽  
Alpha Beta ◽  
Ptp 1B

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP-1B inhibitory activity, in 10 steps. Over the course of this study, two key methodological advances were made: a cost effective procedure for ketone alpha,beta-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2<i>H</i>-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

Asymmetric Total Synthesis and Determination of the Absolute Configuration of (+)-Srilankenyne via Sequence-Sensitive Halogenations Guided by Conformational Analysis

2021 ◽  
Vol 23 (4) ◽  
pp. 1321-1326
Author(s):  
Hongjun Jang ◽  
Soo Yeon Kwak ◽  
Dongjoo Lee ◽  
Juan V. Alegre-Requena ◽  
Hyoungsu Kim ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Conformational Analysis ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
The Absolute

scholarly journals Antioxidant activity, xanthine oxidase inhibitory activity, and compounds determination of Cipadessa baccifera leaf extract

2021 ◽  
Author(s):  
Syarifah Ramadhani Lubis ◽  
Subandi Subandi ◽  
Muntholib Muntholib ◽  
Jamilah Abbas ◽  
Tjandrawati Mozef
Keyword(s):  
Antioxidant Activity ◽  
Xanthine Oxidase ◽  
Inhibitory Activity ◽  
Leaf Extract

scholarly journals Total Synthesis and Inhibitory Activity against Gelatinase B of YL 01869P.

1995 ◽  
Vol 48 (1) ◽  
pp. 87-88 ◽  
Author(s):  
KAZUHIKO TAMAKI ◽  
AKI MATSUBARA ◽  
KAZUHIKO TANZAWA ◽  
YUKIO SUGIMURA
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Gelatinase B

Boehmenan, a lignan from Hibiscus ficulneus, showed Wnt signal inhibitory activity

2015 ◽  
Vol 25 (14) ◽  
pp. 2735-2738 ◽  
Author(s):  
Takumi Shono ◽  
Naoki Ishikawa ◽  
Kazufumi Toume ◽  
Midori A. Arai ◽  
Firoj Ahmed ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Wnt Signal

Total synthesis and determination of the absolute configuration of (−)-longilene peroxide

2001 ◽  
Vol 42 (36) ◽  
pp. 6307-6309 ◽  
Author(s):  
Yoshiki Morimoto ◽  
Toshiyuki Iwai ◽  
Takamasa Kinoshita
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
The Absolute

Total synthesis of nafuredin-γ, a γ-lactone related to nafuredin with selective inhibitory activity against NADH-fumarate reductase

2003 ◽  
Vol 44 (34) ◽  
pp. 6441-6444 ◽  
Author(s):  
Tohru Nagamitsu ◽  
Daisuke Takano ◽  
Kazuro Shiomi ◽  
Hideaki Ui ◽  
Yuichi Yamaguchi ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Fumarate Reductase
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