scholarly journals Use of B‐complex vitamins and olfactory training for treating COVID‐19–related anosmia

2021 ◽  
Vol 9 (11) ◽  
Author(s):  
Yethindra Vityala ◽  
Aliya Kadyrova ◽  
Shirin Zhumabaeva ◽  
Aizhan Bazarbaeva ◽  
Sagynali Mamatov
Author(s):  
Yethindra Vityala ◽  
Shirin Zhumabaeva ◽  
Baktygul Imankulova ◽  
Alina Kurmanalieva ◽  
Sagynali Mamatov

A 42-year-old male patient was diagnosed with coronavirus disease 2019. His symptoms improved 2 weeks after lopinavir therapy (400 mg every 12 hours). However, he was subsequently diagnosed with complete anosmia. Magnetic resonance brain imaging showed no abnormalities. We prescribed B-complex vitamins and olfactory training. Forty days later, he recovered.


2021 ◽  
Vol 190 ◽  
pp. 105322
Author(s):  
Nemanja M. Jovanovic ◽  
Uros Glavinic ◽  
Biljana Delic ◽  
Branislav Vejnovic ◽  
Nevenka Aleksic ◽  
...  

ORL ◽  
2021 ◽  
pp. 1-8
Author(s):  
Sotiria Genetzaki ◽  
Evangelia Tsakiropoulou ◽  
Vasilios Nikolaidis ◽  
Konstantinos Markou ◽  
Iordanis Konstantinidis

<b><i>Introduction:</i></b> There are limited treatment options for postinfectious olfactory dysfunction (PIOD). Olfactory training has recently been used in clinical practice, but no medical treatment is widely accepted. Although there is weak evidence for their value, some physicians use oral corticosteroids as first-line treatment. The aim of this study was to compare combined oral methylprednisolone and olfactory training with olfactory training alone in the management of PIOD. <b><i>Methods:</i></b> This prospective cohort study included 131 patients with PIOD over a 2-year period before the COVID-19 pandemic. Seventy-eight patients who were treated with oral methylprednisolone and olfactory training (group A) were compared with 53 patients who were treated with olfactory training only (group B). Olfactory function was evaluated with “Sniffin’ Sticks” at baseline and 2, 8, and 16 weeks after initial assessment. Patients who improved after steroid treatment underwent magnetic resonance imaging of the paranasal sinuses, skin prick tests, lung spirometry, and sputum eosinophil assessment. <b><i>Results:</i></b> Oral steroids improved 19.23% of patients (<i>n</i> = 15) of group A. History, clinical evaluation, imaging, and laboratory tests identified an inflammatory background in half of them (<i>n</i> = 8). The remaining 7 had no findings of nasal inflammation, and all had a short history of olfactory dysfunction. Both groups significantly improved in olfactory testing results at the end of the olfactory training scheme without significant difference between them. <b><i>Conclusions:</i></b> The percentage of improved patients after oral methylprednisolone was relatively low to suggest it as first-line treatment. Half of the improved patients had an underlying upper airway inflammatory condition not related to the infection that caused the acute loss of olfactory function.


2013 ◽  
Vol 49 (5) ◽  
pp. 342-346 ◽  
Author(s):  
Lionel Sebbag ◽  
Nicole Smee ◽  
Deon van der Merwe ◽  
Dustin Schmid

A 2.5 yr old spayed female Weimaraner presented after ingestion of blue-green algae (Microcystis spp.). One day prior to presentation, the patient was swimming at a local lake known to be contaminated with high levels of blue-green algae that was responsible for deaths of several other dogs the same summer. The patient presented 24 hr after exposure with vomiting, inappetence, weakness, and lethargy. Blood work at the time of admission was consistent with acute hepatic failure, characteristic findings of intoxication by Microcystis spp. Diagnosis was suspected by analyzing a water sample from the location where the patient was swimming. Supportive care including fluids, fresh frozen plasma, whole blood, vitamin K, B complex vitamins, S-adenosyl methionine, and Silybum marianum were started. The patient was discharged on supportive medications, and follow-up blood work showed continued improvement. Ingestion is typically fatal for most patients. This is the first canine to be reported in the literature to survive treatment after known exposure.


2018 ◽  
Vol 35 (22) ◽  
pp. 2641-2652 ◽  
Author(s):  
Cristóbal Langdon ◽  
Eduardo Lehrer ◽  
Joan Berenguer ◽  
Sara Laxe ◽  
Isam Alobid ◽  
...  

Perception ◽  
2016 ◽  
Vol 46 (3-4) ◽  
pp. 343-351 ◽  
Author(s):  
Sophia C. Poletti ◽  
Elisabeth Michel ◽  
Thomas Hummel

Background Repeated short-term exposure to odors is known to improve olfaction in patients with acquired olfactory dysfunction. The aim was to find out whether differences in molecular weight of odors used for olfactory training influences olfaction. We hypothesized a greater improvement following training with light weight molecule (LWM) odors. Methods A prospective study was performed in patients with posttraumatic (PTOL) and postviral olfactory loss (PVOL). Olfactory training was performed over a period of 5 months. One group ( n = 48) used four odors containing heavy weight molecules (HWM; >150 g/mol) and another ( n = 48) containing LWM (<150 g/mol). Olfaction was tested before and after the training using the Sniffin’ Sticks test. Results Olfactory training was associated with olfactory improvement, with the improvement in PVOL patients being three times greater than that seen in the PTOL group. Compared with LWM training, HWM training was associated with a significantly greater improvement in Phenyl Ethyl Alcohol (PEA) threshold scores in PVOL patients; however, no such improvement could be shown for other subtests or in PTOL patients. Conclusion Overall, training was associated with olfactory improvement. With the exception of threshold scores in PVOL, there were no significant differences between LWM and HWM groups.


1986 ◽  
Vol 53 (3) ◽  
pp. 391-406 ◽  
Author(s):  
John E. Ford ◽  
Monika J. A. Schröder ◽  
Michael A. Bland ◽  
Kim S. Blease ◽  
K. John Scott

SUMMARYFor milk from four herds of cows, maintained under different conditions of feeding and management, the natural Cu content and the stability of the ascorbate were highly correlated. Low Cu levels in milk from cows at pasture at farms A and B during the summer were associated with low storage losses of ascorbate. During this period, the milk of cows at farms C and D (on forage and Cu-supplemented concentrate) was richer in Cu, and losses of ascorbate were high. Heat treatment of the milk stabilized the ascorbate. Thus, in ‘high Cu’ milk (60 µg Cu/l), loss of ascorbate in the raw milk was 58% at 2 d, as against 17% after pasteurization at 72 °C and no loss after treatment at 82 °C. Storage of milk in light caused rapid destruction of ascorbate, equally with 72 and 82 °C heat treatments. The effects were examined of milk pasteurization temperature (72–82 °C) on flavour stability, bacteriological quality and vitamins of the B-complex. Heat treatment at 82 °C increased the susceptibility of vitamin B12 to destruction by light, but otherwise caused no greater losses of B-complex vitamins than did treatment at 72 °C. Taste panel ratings showed an initial preference for milk heated at 72 °C, but on storage of this milk in darkness the flavour score fell progressively and at 5 d it was judged ‘stale’. Treatment at 82 °C gave a faint ‘cooked’ flavour although, unlike that of the 72 °C-treated milk, the flavour remained stable throughout 14-d storage and after d 8 was increasingly preferred. On exposure to light after treatment at 72 °C milks rapidly acquired an unpleasant‘oxidized’ flavour, but after treatment at 82 °C, exposure to light had no such adverse effect on flavour during the early days of storage. Pasteurization at ∼ 80 °C offers a potential for improvement in the oxidative stability of milk and its contribution of vitamin C to the diet.


2016 ◽  
Vol 11 (4) ◽  
pp. 998-1005 ◽  
Author(s):  
S. Negoias ◽  
K. Pietsch ◽  
T. Hummel

1952 ◽  
Vol 28 (1) ◽  
pp. 49-52
Author(s):  
Beulah D. Westerman ◽  
Gladys E. Vail ◽  
June Kalen ◽  
Miriam Stone ◽  
D.L. Mackintosh

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