ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF REDUCED DIASTEREOISOMERIC AND QUATERNARY AMMONIUM DERIVATIVES OF CALCIUM ANTAGONISTIC (METHYLENEDIOXY)INDENES ON THE ISOLATED RAT AORTA

1982 ◽  
Vol 13 (35) ◽  
Author(s):  
D. T. WITIAK ◽  
R. J. BRUMBAUGH ◽  
R. J. HEASLIP ◽  
R. G. RAHWAN
Keyword(s):  
Quaternary Ammonium ◽  
Rat Aorta ◽  
Pharmacological Evaluation ◽  
Derivatives Of ◽  
Isolated Rat

Effects of liposome-entrapped adenosine in the isolated rat aorta

1993 ◽  
Vol 250 (3) ◽  
pp. 489-492 ◽  
Author(s):  
Eugen Brailoiu ◽  
Dragomir N. Serban ◽  
Sebastian Slatineanu ◽  
Catalin M. Filipeanu ◽  
Bogdan C. Petrescu ◽  
...  
Keyword(s):  
Rat Aorta ◽  
Isolated Rat

Human plasma-derived material with clonidine displacing substance (CDS)-like properties contracts the isolated rat aorta

1991 ◽  
Vol 11 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Dennis Synetos ◽  
Vangelis G. Manolopoulos ◽  
Daphne Atlas ◽  
Eva Pipili-Synetos
Keyword(s):  
Human Plasma ◽  
Rat Aorta ◽  
Isolated Rat

Effects of newly synthesized derivatives of caffeine-8-thioglycolic acid on isolated rat subcellular fractions

2016 ◽  
Vol 258 ◽  
pp. S290-S291
Author(s):  
A.V. Kasabova ◽  
M. Kondeva Burdina ◽  
J. Mitkov ◽  
M. Georgieva ◽  
V. Tzankova ◽  
...  
Keyword(s):  
Thioglycolic Acid ◽  
Subcellular Fractions ◽  
Derivatives Of ◽  
Isolated Rat

Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent

2011 ◽  
Vol 89 (7) ◽  
pp. 467-476 ◽  
Author(s):  
Ji Seok Baik ◽  
Ju-Tae Sohn ◽  
Seong-Ho Ok ◽  
Jae-Gak Kim ◽  
Hui-Jin Sung ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Smooth Muscle ◽  
Calcium Influx ◽  
Rat Aorta ◽  
Isometric Tension ◽  
Guanosine Monophosphate ◽  
Response Curves ◽  
Calcium Dependent ◽  
Isolated Rat

Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels. The goals of this study were to investigate the calcium-dependent mechanism underlying levobupivacaine-induced contraction of isolated rat aorta in vitro and to elucidate the pathway responsible for the endothelium-dependent attenuation of levobupivacaine-induced contraction. Isolated rat aortic rings were suspended to record isometric tension. Cumulative levobupivacaine concentration–response curves were generated in either the presence or absence of the antagonists verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, Gd3+, NW-nitro-l-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), and methylene blue, either alone or in combination. Verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, low calcium concentrations, and calcium-free Krebs solution attenuated levobupivacaine-induced contraction. Gd3+ had no effect on levobupivacaine-induced contraction. Levobupivacaine increased intracellular calcium levels in vascular smooth muscle cells. L-NAME, ODQ, and methylene blue increased levobupivacaine-induced contraction in endothelium-intact aorta. SKF-96365 attenuated calcium-induced contraction in a previously calcium-free isotonic depolarizing solution containing 100 mmol/L KCl. Levobupivacaine-induced contraction of rat aortic smooth muscle is mediated primarily by calcium influx from the extracellular space mainly via voltage-operated calcium channels and, in part, by inositol 1,4,5-trisphosphate receptor-mediated release of calcium from the sarcoplasmic reticulum. The nitric oxide – cyclic guanosine monophosphate pathway is involved in the endothelium-dependent attenuation of levobupivacaine-induced contraction.

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