Effects of newly synthesized derivatives of caffeine-8-thioglycolic acid on isolated rat subcellular fractions

2016 ◽  
Vol 258 ◽  
pp. S290-S291
Author(s):  
A.V. Kasabova ◽  
M. Kondeva Burdina ◽  
J. Mitkov ◽  
M. Georgieva ◽  
V. Tzankova ◽  
...  
Keyword(s):  
Thioglycolic Acid ◽  
Subcellular Fractions ◽  
Derivatives Of ◽  
Isolated Rat

scholarly journals Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine

2012 ◽  
Vol 77 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Ritu Sharma ◽  
Pushkal Samadhiya ◽  
Savitri Srivastava ◽  
Santosh Srivastava
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
Thioglycolic Acid ◽  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Knoevenagel Reaction ◽  
Antituberculosis Activity ◽  
Bacteria And Fungi ◽  
Derivatives Of ◽  
Anhydrous Zncl2

A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized. The cycloaddition reaction of thioglycolic acid with N-[3-(10H-phenothiazinyl)-propyl]-N?-[(substituted phenyl)-methylidene]- urea, 3(a-s) in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo- 1,3-thiazolidine-carboxamide, 4(a-s). The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa undergoes Knoevenagel reaction to yield 5(a-s). The structure of compounds 1, 2, 3(a-s), 4(a-s) and 5(a-s) were confirmed by IR, 1H NMR, 13C NMR, Fmass and chemical analysis. All above compounds were screened for their antimicrobial activity against some selected bacteria and fungi and for antituberculosis activity compounds have been screened against the bacterium M. tuberculosis.

scholarly journals Spectral-luminescent properties of derivatives of squaraine probes at interaction with the isolated rat liver cells

2012 ◽  
Vol 28 (3) ◽  
pp. 229-233 ◽  
Author(s):  
T. N. Tkachova ◽  
N. S. Kavok ◽  
I. A. Borovoy ◽  
O. M. Obukhova ◽  
S. A. Klimov ◽  
...  
Keyword(s):  
Rat Liver ◽  
Luminescent Properties ◽  
Liver Cells ◽  
Isolated Rat Liver ◽  
Rat Liver Cells ◽  
Spectral Luminescent Properties ◽  
Derivatives Of ◽  
Isolated Rat

SYNTHESIS AND SOME TRANSFORMATIONS OF HETEROCYCLIC SUBSTITUTED DERIVATIVES OF THIOGLYCOLICACID

2020 ◽  
Vol 54 (2 (252)) ◽  
pp. 93-98
Author(s):  
M.A. Samvelyan ◽  
T.V. Ghochikyan
Keyword(s):  
Thioglycolic Acid ◽  
Derivatives Of

The methods have been developed for the preparation of diheterocyclic systems of a new structure, such as pyrazolo- and 1,3,4-oxadiazolo-1,2,4-triazoles, based on S-substituted thioglycolic acid derivatives.

scholarly journals The biosynthesis of sulphogalactosyldiacylglycerol of rat brain in vitro

1977 ◽  
Vol 166 (3) ◽  
pp. 429-435 ◽  
Author(s):  
G. Subba Rao ◽  
Leonard N. Norcia ◽  
Joanne Pieringer ◽  
Ronald A. Pieringer
Keyword(s):  
Enzyme Activity ◽  
Rat Brain ◽  
Enzyme Preparation ◽  
Microsomal Fraction ◽  
Inhibitory Effect ◽  
Subcellular Fractions ◽  
Triton X ◽  
Derivatives Of

Triton X-100 extracts of rat brain microsomal fraction catalyse the formation of sulphogalactosyldiacylglycerol from galactosyldiacylglycerol and adenosine 3′-phosphate 5′-sulphatophosphate. Of the various subcellular fractions of brain assayed, the microsomal fraction contained most (79%) of the adenosine 3′-phosphate 5′-sulphatophosphate–galactosyldiacylglycerol sulphotransferase activity. The enzyme activity was stimulated by Triton X-100 and showed linearity with increasing time, concentrations of enzyme and added substrates. ATP and KF prolonged the linearity of the activity with time, but ATP had an overall inhibitory effect on the sulphotransferase. Both ATP and KF inhibit the degradation of adenosine 3′-phosphate 5′-sulphatophosphate, which probably causes the increased linearity of the sulphotransferase reaction with time. The enzyme preparation did not catalyse the transfer of sulphate from adenosine 3′-phosphate 5′-sulphatophosphate to either cholesterol or galabiosyldiacylglycerol (galactosylgalactosyldiacylglycerol). Significant differences between the formation of sulphogalactosyldiacylglycerol and cerebroside sulphate catalysed by the same enzyme preparation were noted. ATP and Mg2+ strongly inhibit the formation of sulphogalactosyldiacylglycerol but equally strongly stimulate the synthesis of cerebroside sulphate. The apparent Km for galactosyldiacylglycerol is 200μm, and that for cerebroside is 45μm. Galactosyldiacylglycerol and cerebroside are mutually inhibitory toward the synthesis of sulphated derivatives of each. These data do not necessarily lead to the conclusion that two sulphotransferases are present, but they do indicate a possible means of controlling the synthesis of these two sulpholipids.

Action of some luteinizing hormone derivatives in ovaries from pseudopregnant rats: dissimilarities between their activities on this organ and on Leydig cells

1983 ◽  
Vol 96 (3) ◽  
pp. 365-372 ◽  
Author(s):  
M.P. de la Llosa-Hermier ◽  
C. Tertrin-Clary ◽  
M. Evrard-Hérouard ◽  
C. Hermier ◽  
P. de la Llosa
Keyword(s):  
Leydig Cells ◽  
Biological Activities ◽  
Inhibition Activity ◽  
Amino Groups ◽  
Α Subunit ◽  
Binding Inhibition ◽  
Lysine Residues ◽  
Derivatives Of ◽  
Isolated Rat ◽  
Good Agreement

Biological activities of several derivatives of ovine LH obtained by chemical modification of the amino groups were investigated using ovaries from pseudopregnant rats. Binding-inhibition activities and steroidogenic potencies of ethylated, isopropylated and guanidinated LH were in good agreement, whereas adenylate cyclase activities were relatively greater. When compared with previous results on binding-inhibition activities and steroidogenic potencies using isolated rat Leydig cells, the ovaries from pseudopregnant rats appeared to be more discriminating. Ethylated and isopropylated derivatives exhibited lower binding-inhibition activities and steroidogenic potencies in female gonads. This difference was particularly evident in the case of guanidinated LH which exhibited a very low binding-inhibition activity and consequently was unable to act as an inhibitor of the action of LH on the ovaries. Guanidinated porcine LH (in which all the lysine residues of the α-subunit were transformed into homoarginine, without modification of the β-subunit which does not contain lysine) showed similar biological activities to guanidinated ovine LH in the isolated Leydig cells as well as in pseudopregnant ovaries. It can, consequently, act as an inhibitor of LH action on Leydig cells but not on the ovary of the pseudopregnant rat. Thus, the inhibitory properties of this derivative can be ascribed to the modification introduced in the α-subunit.

Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: Characterization of subcellular fractions

1983 ◽  
Vol 763 (4) ◽  
pp. 393-407 ◽  
Author(s):  
Ian A. Simpson ◽  
Dena R. Yver ◽  
Paul J. Hissin ◽  
Lawrence J. Wardzala ◽  
Eddy Karnieli ◽  
...  
Keyword(s):  
Glucose Transporters ◽  
Subcellular Fractions ◽  
Adipose Cells ◽  
Isolated Rat
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