ChemInform Abstract: Comparison of Metal-Hydrogen, -Oxygen, -Nitrogen and -Carbon Bond Strengths and Evaluation of Functional Group Additivity Principles for Organoruthenium and Organoplatinum Compounds.

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

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Nickel-Catalyzed Electronically-Reversed Enantioselective Hydrocarbofunctionalizations of Acrylamides

Synlett ◽

10.1055/a-1478-2280 ◽

2021 ◽

Author(s):

Lou Shi ◽

Wei Shu

Keyword(s):

Nickel Catalyst ◽

Functional Group ◽

Optically Active ◽

Forming Process ◽

Carbon Bond ◽

Bond Forming ◽

Synthetic Strategy ◽

Carbon Carbon Bond ◽

Wide Range ◽

Simple Protocol

Asymmetric hydrocarbofunctionalizations of alkenes has emerged as an efficient synthetic strategy for accessing optically active molecules via carbon-carbon bond-forming process from readily available alkenes and carbo-electrophiles. Herein, we present a summary of the efforts from our group to control the regio- and enantioselectivity of hydrocarbofunctionalizations of electron-deficient alkenes with a nickel catalyst and chiral bisoxazolidine ligand. The reaction undergoes electron-reversed hydrocarbofunctionalizations acrylamides with excellent enantioselectivity. This operationally simple protocol enables the asymmetric hydroalkylation, hydrobenzylation and hydropropargylation of acrylamides. This reaction is useful for preparing a wide range of α-branched chiral amides with broad functional group tolerance.

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ChemInform Abstract: Heterodimerization of Propylene and Vinylarenes: Functional Group Compatibility in a Highly Efficient Ni-Catalyzed Carbon-Carbon Bond-Forming Reaction.

ChemInform ◽

10.1002/chin.200028079 ◽

2010 ◽

Vol 31 (28) ◽

pp. no-no

Author(s):

Jian Jin ◽

T. V. RanjanBabu

Keyword(s):

Functional Group ◽

Carbon Bond ◽

Bond Forming ◽

Highly Efficient ◽

Carbon Carbon Bond

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Standard Partial Molar Volumes of Some Aqueous Alkanolamines and Alkoxyamines at Temperatures up to 325 °C: Functional Group Additivity in Polar Organic Solutes under Hydrothermal Conditions

The Journal of Physical Chemistry B ◽

10.1021/jp711766v ◽

2008 ◽

Vol 112 (18) ◽

pp. 5626-5645 ◽

Cited By ~ 5

Author(s):

E. Bulemela ◽

Peter R. Tremaine

Keyword(s):

Functional Group ◽

Partial Molar Volumes ◽

Group Additivity ◽

Organic Solutes ◽

Hydrothermal Conditions ◽

Molar Volumes

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Enantioselective Palladium-Catalyzed C-C Bond Activation by Merging (3+2) Spiroannulation and Desymmetrization of Cyclic 1,3-Diketones

Chemical Science ◽

10.1039/d1sc04558j ◽

2021 ◽

Author(s):

Han-Qi Zhou ◽

Xing-Wei Gu ◽

Xiao-Hua Zhou ◽

Li Li ◽

Fei Ye ◽

...

Keyword(s):

Functional Group ◽

Bond Activation ◽

Carbon Bond ◽

Carbon Carbon Bond ◽

Palladium Catalyzed ◽

Catalytic Asymmetric

Catalytic asymmetric variants for the functional group-transformations based on carbon-carbon bond activation still remain elusive. Herein we present an unprecedented palladium-catalyzed (3+2) spiro-annulation that merging C(sp2)-C(sp2) s bond activation and...

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