ChemInform Abstract: Catalytic Asymmetric Synthesis of β-Hydroxy Ketones by Palladium- Catalyzed Asymmetric 1,4-Disilylation of α,β-Unsaturated Ketones.

ChemInform ◽  
2010 ◽  
Vol 25 (19) ◽  
pp. no-no
Author(s):  
Y. MATSUMOTO ◽  
T. HAYASHI ◽  
Y. ITO
Keyword(s):  
Asymmetric Synthesis ◽  
Unsaturated Ketones ◽  
Catalytic Asymmetric Synthesis ◽  
Hydroxy Ketones ◽  
Palladium Catalyzed ◽  
Catalytic Asymmetric

Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85058-85062 ◽  
Author(s):  
Mayaka Maeno ◽  
Hiroya Kondo ◽  
Etsuko Tokunaga ◽  
Norio Shibata
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Asymmetric Synthesis ◽  
Therapeutic Agent ◽  
The Self ◽  
Keto Ester ◽  
Catalytic Asymmetric Synthesis ◽  
Palladium Catalyzed ◽  
Catalytic Asymmetric ◽  
Decarboxylative Allylation

Catalytic asymmetric synthesis of fluorinated donepezil, a promising new therapeutic agent for Alzheimer's disease, was achieved.

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