Catalytic asymmetric synthesis of β-hydroxy ketones by palladium-catalyzed asymmetric 1,4-disilylation of α,β-unsaturated ketones

Tetrahedron ◽  
1994 ◽  
Vol 50 (2) ◽  
pp. 335-346 ◽  
Author(s):  
Yonetatsu Matsumoto ◽  
Tamio Hayashi ◽  
Yoshihiko Ito
RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85058-85062 ◽  
Author(s):  
Mayaka Maeno ◽  
Hiroya Kondo ◽  
Etsuko Tokunaga ◽  
Norio Shibata

Catalytic asymmetric synthesis of fluorinated donepezil, a promising new therapeutic agent for Alzheimer's disease, was achieved.


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