ChemInform Abstract: Novel Halogenated Sulfonamides Inhibit the Growth of Multidrug Resistant MCF-7/ADR Cancer Cells.

ChemInform ◽  
2010 ◽  
Vol 30 (43) ◽  
pp. no-no
Author(s):  
Julio C. Medina ◽  
Daniel Roche ◽  
Bei Shan ◽  
R. Marc Learned ◽  
Walter P. Frankmoelle ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Multidrug Resistant ◽  
Mcf 7

Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

1999 ◽  
Vol 9 (13) ◽  
pp. 1843-1846 ◽  
Author(s):  
Julio C. Medina ◽  
Daniel Roche ◽  
Bei Shan ◽  
R.Marc Learned ◽  
Walter P. Frankmoelle ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Multidrug Resistant ◽  
Mcf 7

scholarly journals Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells.

1995 ◽  
Vol 96 (2) ◽  
pp. 1026-1034 ◽  
Author(s):  
S Scala ◽  
A Budillon ◽  
Z Zhan ◽  
Y S Cho-Chung ◽  
J Jefferson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mdr 1 ◽  
Mcf 7

scholarly journals JNK1/2 Activation by an Extract from the Roots ofMorus albaL. Reduces the Viability of Multidrug-Resistant MCF-7/Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Youn Kyung Choi ◽  
Sung-Gook Cho ◽  
Hyeong Sim Choi ◽  
Sang-Mi Woo ◽  
Yee Jin Yun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Nuclear Translocation ◽  
Multidrug Resistant ◽  
Morus Alba ◽  
Root Extract ◽  
Multidrug Resistance Gene ◽  
Mdr1 Expression ◽  
Mcf 7

Cancer cells acquire anticancer drug resistance during chemotherapy, which aggravates cancer disease. MDR1 encoded from multidrug resistance gene 1 mainly causes multidrug resistance phenotypes of different cancer cells. In this study, we demonstrate that JNK1/2 activation by an extract from the root ofMorus albaL. (White mulberry) reduces doxorubicin-resistant MCF-7/Dox cell viability by inhibiting YB-1 regulation ofMDR1gene expression. When MCF-7 or MCF-7/Dox cells, where MDR1 is highly expressed were treated with an extract from roots or leaves ofMorus albaL., respectively, the root extract from the mulberry (REM) but not the leaf extract (LEM) reduced cell viabilities of both MCF-7 and MCF-7/Dox cells, which was enhanced by cotreatment with doxorubicin. REM but not LEM further inhibited YB-1 nuclear translocation and its regulation ofMDR1gene expression. Moreover, REM promoted phosphorylation of c-Jun NH2-terminal kinase 1/2 (JNK1/2) and JNK1/2 inhibitor, SP600125 and rescued REM inhibition of both MDR1 expression and viabilities in MCF-7/Dox cells. Consistently, overexpression of JNK1, c-Jun, or c-Fos inhibited YB-1-dependent MDR1 expression and reduced viabilities in MCF-7/Dox cells. In conclusion, our data indicate that REM-activated JNK-cJun/c-Fos pathway decreases the viability of MCF-7/Dox cells by inhibiting YB-1-dependentMDR1gene expression. Thus, we suggest that REM may be useful for treating multidrug-resistant cancer cells.

MCF-7/ADR cells (re-designated NCI/ADR-RES) are not derived from MCF-7 breast cancer cells: a loss for breast cancer multidrug-resistant research

2010 ◽  
Vol 28 (S1) ◽  
pp. 135-141 ◽  
Author(s):  
Weifeng Ke ◽  
Pei Yu ◽  
Jianfeng Wang ◽  
Ruitao Wang ◽  
Chongyong Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Mcf 7

scholarly journals A multifunctional poly(curcumin) nanomedicine for dual-modal targeted delivery, intracellular responsive release, dual-drug treatment and imaging of multidrug resistant cancer cells

2016 ◽  
Vol 4 (17) ◽  
pp. 2954-2962 ◽  
Author(s):  
Jining Wang ◽  
Feihu Wang ◽  
Fangzhou Li ◽  
Wenjun Zhang ◽  
Yuanyuan Shen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Paclitaxel Resistance ◽  
Simultaneous Imaging ◽  
Anti Cancer ◽  
Cancer Nanomedicine ◽  
Dual Drug ◽  
Mcf 7

A multifunctional anti-cancer nanomedicine PTX/MNPs/QDs@Biotin–PEG–PCDA was developed aiming at overcoming paclitaxel resistance in MCF-7/ADR breast cancer cells with simultaneous imaging.

Salvianolic acid A shows selective cytotoxicity against multidrug-resistant MCF-7 breast cancer cells

2015 ◽  
Vol 26 (2) ◽  
pp. 210-223 ◽  
Author(s):  
Xin Wang ◽  
Chunyan Wang ◽  
Longjiang Zhang ◽  
Yanjun Li ◽  
Shouju Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Selective Cytotoxicity ◽  
Salvianolic Acid ◽  
Salvianolic Acid A ◽  
Mcf 7
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