ChemInform Abstract: Bioactive Natural Products from Papua New Guinea Marine Sponges

ChemInform ◽  
2013 ◽  
Vol 44 (2) ◽  
pp. no-no
Author(s):  
Jeffrey C. Noro ◽  
John A. Kalaitzis ◽  
Brett A. Neilan
Keyword(s):  
Natural Products ◽  
Papua New Guinea ◽  
New Guinea ◽  
Marine Sponges ◽  
Bioactive Natural Products

Bioactive Natural Products from Papua New Guinea Marine Sponges

2012 ◽  
Vol 9 (10) ◽  
pp. 2077-2095 ◽  
Author(s):  
Jeffery C. Noro ◽  
John A. Kalaitzis ◽  
Brett A. Neilan
Keyword(s):  
Natural Products ◽  
Papua New Guinea ◽  
New Guinea ◽  
Marine Sponges ◽  
Bioactive Natural Products

scholarly journals Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

2016 ◽  
Vol Volume 112 (Number 11/12) ◽  
Author(s):  
Elisabeth K. Olsen ◽  
Christopher K. de Cerf ◽  
Godwin A. Dziwornu ◽  
Eleonora Puccinelli ◽  
Isabelle J. Ansorge ◽  
...  
Keyword(s):  
Natural Products ◽  
Southern Ocean ◽  
Cytotoxic Activity ◽  
Marine Invertebrates ◽  
Cold Water ◽  
Research Effort ◽  
Benthic Invertebrate ◽  
Marine Sponges ◽  
Bioactive Natural Products ◽  
Prince Edward Islands

Abstract Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean.

Detection of pharmacologically active natural products using ecology. Selected examples from Indopacific marine invertebrates and sponge-derived fungi

2003 ◽  
Vol 75 (2-3) ◽  
pp. 343-352 ◽  
Author(s):  
P. Proksch ◽  
R. Ebel ◽  
R. A. Edrada ◽  
P. Schupp ◽  
W. H. Lin ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Invertebrates ◽  
Marine Sponges ◽  
Bioactive Metabolites ◽  
Marine Biodiversity ◽  
Marine Microorganisms ◽  
Bioactive Constituents ◽  
Isolation And Identification ◽  
Bioactive Natural Products ◽  
Pharmacologically Active

This review article presents our group's recent research findings with regard to bioactive natural products from marine sponges and tunicates, as well as from sponge derived fungi. The organisms discussed originate in the Indopacific region, which has an exceptionally rich marine biodiversity. Major topics that are covered in our review include the chemical ecology of sponges, focusing on defense against fishes, as well as the isolation and identification of new bioactive constituents from sponges and tunicates. Sponge derived fungi are introduced as an emerging source for new bioactive metabolites, reflecting the currently growing interest in natural products from marine microorganisms.

Bioactive natural products from marine sponges and fungal endophytes

2010 ◽  
Vol 9 (4) ◽  
pp. 475-489 ◽  
Author(s):  
Peter Proksch ◽  
Annika Putz ◽  
Sofia Ortlepp ◽  
Julia Kjer ◽  
Mirko Bayer
Keyword(s):  
Natural Products ◽  
Fungal Endophytes ◽  
Marine Sponges ◽  
Bioactive Natural Products

scholarly journals Bioactive natural products from marine sponges belonging to family Hymedesmiidae

RSC Advances ◽  
2021 ◽  
Vol 11 (27) ◽  
pp. 16179-16191
Author(s):  
Asmaa Abo Elgoud Said ◽  
Basma Khalaf Mahmoud ◽  
Eman Zekry Attia ◽  
Usama Ramadan Abdelmohsen ◽  
Mostafa Ahmed Fouad
Keyword(s):  
Natural Products ◽  
Drug Development ◽  
Biological Activities ◽  
Vital Role ◽  
Marine Sponges ◽  
Marine Origin ◽  
Bioactive Natural Products ◽  
New Compounds

Natural products of marine origin exhibit extensive biological activities, and display a vital role in the exploration of new compounds for drug development.

Bioactive Natural Products from Marine Sponges

2007 ◽  
pp. 195-205 ◽  
Author(s):  
Shixiang Bao ◽  
Biwen Wu ◽  
Huiqin Huang
Keyword(s):  
Natural Products ◽  
Marine Sponges ◽  
Bioactive Natural Products

scholarly journals Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

2017 ◽  
Vol 114 (3) ◽  
pp. E347-E356 ◽  
Author(s):  
Gerald Lackner ◽  
Eike Edzard Peters ◽  
Eric J. N. Helfrich ◽  
Jörn Piel
Keyword(s):  
Natural Products ◽  
Metabolic Model ◽  
Marine Sponges ◽  
Sponge Tissue ◽  
Bioactive Natural Products ◽  
Bacterial Interaction ◽  
Large Expansion ◽  
Modified Peptides ◽  
Almost All

The as-yet uncultured filamentous bacteria “CandidatusEntotheonella factor” and “CandidatusEntotheonella gemina” live associated with the marine spongeTheonella swinhoeiY, the source of numerous unusual bioactive natural products. Belonging to the proposed candidate phylum “Tectomicrobia,”CandidatusEntotheonella members are only distantly related to any cultivated organism. TheCa. E. factor has been identified as the source of almost all polyketide and modified peptides families reported from the sponge host, and bothCa. Entotheonella phylotypes contain numerous additional genes for as-yet unknown metabolites. Here, we provide insights into the biology of these remarkable bacteria using genomic, (meta)proteomic, and chemical methods. The data suggest a metabolic model ofCa. Entotheonella as facultative anaerobic, organotrophic organisms with the ability to use methanol as an energy source. The symbionts appear to be auxotrophic for some vitamins, but have the potential to produce most amino acids as well as rare cofactors like coenzyme F420. The latter likely accounts for the strong autofluorescence ofCa. Entotheonella filaments. A large expansion of protein families involved in regulation and conversion of organic molecules indicates roles in host–bacterial interaction. In addition, a massive overrepresentation of members of the luciferase-like monooxygenase superfamily points toward an important role of these proteins inCa. Entotheonella. Furthermore, we performed mass spectrometric imaging combined with fluorescence in situ hybridization to localizeCa. Entotheonella and some of the bioactive natural products in the sponge tissue. These metabolic insights into a new candidate phylum offer hints on the targeted cultivation of the chemically most prolific microorganisms known from microbial dark matter.

scholarly journals Bioactive Natural Products of Marine Sponges from the Genus Hyrtios

Molecules ◽  
2017 ◽  
Vol 22 (5) ◽  
pp. 781 ◽  
Author(s):  
Nourhan Shady ◽  
Ebaa El-Hossary ◽  
Mostafa Fouad ◽  
Tobias Gulder ◽  
Mohamed Kamel ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Sponges ◽  
Bioactive Natural Products

scholarly journals Natural Products from the Marine Sponge Subgenus Reniera

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1097
Author(s):  
Xuelian Bai ◽  
Yang Liu ◽  
Hao Wang ◽  
Huawei Zhang
Keyword(s):  
Natural Products ◽  
Therapeutic Potential ◽  
Chemical Study ◽  
Biological Properties ◽  
Marine Sponges ◽  
Extensive Literature ◽  
Lead Discovery ◽  
Bioactive Natural Products ◽  
Drug Lead ◽  
Extensive Literature Search

Marine sponges are one of the prolific producers of bioactive natural products with therapeutic potential. As an important subgenus of Haliclona, Reniera sponges are mainly distributed in the Mediterranean Sea and Atlantic area, and had been chemically investigated for over four decades. By an extensive literature search, this review first makes a comprehensive summary of all natural products from Reniera sponges and their endozoic microbes, as well as biological properties. Perspectives on strengthening the chemical study of Reniera sponges for new drug-lead discovery are provided in this work.

Sign in / Sign up

Export Citation Format

Share Document