Geodiversity of surface karst features of geographical zones

The diversity of small, medium, and large solution features of zonal karsts and high mountain karsts is described here. It was taken into consideration how diversity changes according to the distance from the Equator in case of small, medium and large features of various zonal karsts and how it varies based on the distance from altitude in case of the karren features (small features) of high mountain karsts. It can be established that the diversity of karst features decreases according to the distance from the Equator (independent of the size of the features), while in high mountains the diversity of karren features first increases with altitude and then it decreases. The decrease of the diversity of medium and large features moving away from the Equator can be explained by the decrease of dissolution in­tensity. The diversity change of karren features shows a rela­tion with the diversity of the inclination of the bearing slope. Since on tropical karsts and in the medium elevated areas of high mountains (1600-2100 m) where bare slopes with large expansion and various slope inclination occur, the diversity of karren is great. On tropical karsts, slopes with diverse inclina­tion were created by karstification and in high mountains by glacial erosion.

Ground-Based GNSS and Satellite Observations of Auroral Ionospheric Irregularities during Geomagnetic Disturbances in August 2018

The 25–26 August 2018 space weather event occurred during the solar minimum period and surprisingly became the third largest geomagnetic storm of the entire 24th solar cycle. We analyzed the ionospheric response at high latitudes of both hemispheres using multi-site ground-based GNSS observations and measurements onboard Swarm and DMSP satellites. With the storm development, the zones of intense ionospheric irregularities of auroral origin largely expanded in size and moved equatorward towards midlatitudes as far as ~55–60° magnetic latitude (MLAT) in the American, European, and Australian longitudinal sectors. The main ionospheric trough, associated with the equatorward side of the auroral oval, shifted as far equatorward as 45–50° MLAT at both hemispheres. The interhemispheric comparison revealed a high degree of similarity in a large expansion of the auroral irregularities oval towards midlatitudes, in addition to asymmetrical differences in terms of larger intensity of plasma density gradients and structures over the Southern auroral and polar cap regions. Evolution of the intense ionospheric irregularities and equatorward expansion of the auroral irregularities oval were well correlated with increases of geomagnetic activity and peaks of the auroral electrojet index.

The relevance of Chemistry in Tumor microenvironment of Cancer Patient

The prime mechanisms for the alteration or reshaping of common somatic gene cells into malignant tumor gene cells are transgenic or oncogene activation and tumor-suppresser gene cell dismission. Cancer genetic cells are the propulsion of growing and expansion. On the other side, they are incapable of developing them self. The wen microhabitat is thought of plays an extra energetic role in Wen improvement than merely existing as a bystander. Wen Cells dexterously enroll connective tissue cells. Through several walkways, which then supply Wen Cells with improved Signs, median metabolites, and a favorable environment for tumor expansion and metastasis. Lymphoma or tumor cells and the microhabitat environment work both will promote large expansion and metathetical potential through mutual communication. Understanding the play of the wen or tumor sensitive small environment in Wen Expansion can direct to new routes to target the Wen Small environment for more efficient anti-tumor medications or cures. In this study, we address the methods involved in Wen or tumor cells enrolling connective cells to the prime tumor place. Along with that it also explained and highlighted the small microhabitats environment and tumor development process. We also mentioned some of the possible potential treatment approaches of cancer treatment which can mighty be helpful for better results.

Immunotherapeutic early-phase clinical trials and malignant gliomas: a single-center experience and comprehensive immunophenotyping of circulating leukocytes

Background Immunotherapeutic early-phase clinical trials (ieCTs) increasingly adopt large expansion cohorts exploring novel agents across different tumor types. High-grade glioma (HGG) patients are usually excluded from these trials. Methods Data of patients with recurrent HGGs treated within multicohort ieCTs between February 2014 and August 2019 (experimental group, EG) at our Phase I Unit were retrospectively reviewed and compared to a matched control group (CG) of patients treated with standard therapies. We retrospectively evaluated clinical, laboratory, and molecular parameters through univariate and multivariate analysis. A prospective characterization of circulating leukocyte subpopulations was performed in the latest twenty patients enrolled in the EG, with a statistical significance cutoff of p <0.1. Results Thirty HGG patients were treated into six ieCTs. Fifteen patients received monotherapies (anti PD-1, anti CSF-1R, anti TGFβ, anti cereblon), fifteen patients combination regimens (anti PD-L1 + anti CD38, anti PD-1 + anti CSF-1R). In the EG, median progression-free survival and overall survival (OS) from treatment initiation were 1.8 and 8.6 months; twelve patients survived more than 12 months, and two of them more than six years. Univariate analysis identified O 6-methylguanine DNA methyltransferase (MGMT) promoter methylation and total protein value at six weeks as significantly correlated with a better outcome. Decreased circulating neutrophils and increased conventional dendritic cells levels lead to significantly better OS. Conclusions A subgroup of EG patients achieved remarkably durable disease control. MGMT promoter methylation identifies patients who benefit more from immunotherapy. Monitoring dynamic changes of innate immune cell populations may help to predict clinical outcomes.

La calle proyectada en el planeamiento urbanístico reciente. Murcia, 2001-2016

The 'prodigious decade' of Spanish urbanism caused a large expansion of urban lands, but also a much greater amount of planned but undeveloped land. The planning for this 'expectant city' is a challenge for the future of our cities. In this work, the streets proposed in these plans are analysed by evaluating their dimensional characteristics (surface and width) and their habitability (pedestrian-cyclist space and previsions of tree lines). The research is focused on the city of Murcia, paradigmatic case of the expansive urbanism typical of the real estate bubble. We have studied 2,096 streets from 92 partial plans approved during the period 2002-2013. The results show how the analysed variables change according to the use and density of the sectors and can be useful to evaluate the improvement of the habitability of these streets before their execution.

The Effects of DNA Databases on the Deterrence and Detection of Offenders

This paper studies the effects of adding criminal offenders to a DNA database. Using a large expansion of Denmark’s DNA database, we find that DNA registration reduces recidivism within the following year by up to 42 percent. It also increases the probability that offenders are identified if they recidivate, which we use to estimate the elasticity of crime with respect to the detection probability and find that a 1 percent higher detection probability reduces crime by more than 2 percent. We also find that DNA registration increases the likelihood that offenders find employment, enroll in education, and live in a more stable family environment. (JEL J22, J24, K42)

Synergistic Manipulation of Zero-Dimension and One-Dimension Hybrid Nanofillers in Multi-Layer Two-Dimension Thin Films to Construct Light Weight Electromagnetic Interference Material

Nanocomposite foam with a large expansion ratio and thin cell walls is promising for electromagnetic interference (EMI) shielding materials, due to the low electromagnetic (EM) reflection and high EM absorption. To overcome the dimensional limitation from two-dimension (2D) thin walls on the construction of conductive network, a strategy combining hybrid conductive nanofillers in semi-crystalline matrix together with supercritical CO2 (scCO2) foaming was applied: (1) one-dimension (1D) CNTs with moderate aspect ratio was used to minimize the dimensional confinement from 2D thin walls while constructing the main EM absorbing network; (2) zero-dimension (0D) carbon black (CB) with no dimensional confinement was used to connect the separated CNTs in thin walls and to expand the EM absorbing network; (3) scCO2 foaming was applied to obtain a cellular structure with multi-layer thin walls and a large amount of air cells to reduce the reflected EM; (4) semi-crystalline polymer was selected so that the rheological behavior could be adjusted by optimizing crystallization and filler content to regulate the cellular structure. Consequently, an advanced material featured as lightweight, high EM absorption and low EM reflection was obtained at 0.48 vol.% hybrid nanofillers and a density of 0.067 g/cm3, whose specific EMI shielding performance was 183 dB cm3/g.

Will Plant Genome Editing Play a Decisive Role in “Quantum-Leap” Improvements in Crop Yield to Feed an Increasing Global Human Population?

Growing scientific evidence demonstrates unprecedented planetary-scale human impacts on the Earth’s system with a predicted threat to the existence of the terrestrial biosphere due to population increase, resource depletion, and pollution. Food systems account for 21–34% of global carbon dioxide (CO2) emissions. Over the past half-century, water and land-use changes have significantly impacted ecosystems, biogeochemical cycles, biodiversity, and climate. At the same time, food production is falling behind consumption, and global grain reserves are shrinking. Some predictions suggest that crop yields must approximately double by 2050 to adequately feed an increasing global population without a large expansion of crop area. To achieve this, “quantum-leap” improvements in crop cultivar productivity are needed within very narrow planetary boundaries of permissible environmental perturbations. Strategies for such a “quantum-leap” include mutation breeding and genetic engineering of known crop genome sequences. Synthetic biology makes it possible to synthesize DNA fragments of any desired sequence, and modern bioinformatics tools may hopefully provide an efficient way to identify targets for directed modification of selected genes responsible for known important agronomic traits. CRISPR/Cas9 is a new technology for incorporating seamless directed modifications into genomes; it is being widely investigated for its potential to enhance the efficiency of crop production. We consider the optimism associated with the new genetic technologies in terms of the complexity of most agronomic traits, especially crop yield potential (Yp) limits. We also discuss the possible directions of overcoming these limits and alternative ways of providing humanity with food without transgressing planetary boundaries. In conclusion, we support the long-debated idea that new technologies are unlikely to provide a rapidly growing population with significantly increased crop yield. Instead, we suggest that delicately balanced humane measures to limit its growth and the amount of food consumed per capita are highly desirable for the foreseeable future.

St18 specifies globus pallidus projection neuron identity in MGE lineage

The medial ganglionic eminence (MGE) is a progenitor domain in the subpallium that produces both locally-projecting interneurons which undergo tangential migration in structures such as the cortex as well as long-range projection neurons that occupy subcortical nuclei. Very little is known about the transcriptional mechanisms specifying the migratory behavior and axonal projection patterns of these two broad classes of MGE-derived neurons. In this study, we identify St18 as a novel transcriptional determinant specifying projection neuron fate in the MGE lineage. St18 is transiently expressed in the MGE subventricular zone (SVZ) and mantle, and we assessed its function using an ES cell-based model of MGE development. Induction of St18 is sufficient to direct ES-derived MGE neurons to adopt a projection neuron-like identity as defined by migration and morphology. Using genetic loss-of-function in mice, we find that St18 is required for the production of globus pallidus pars externa (GPe) prototypic projection neurons. Single cell RNA sequencing revealed that St18 regulates MGE output of specific neuronal populations: in the absence of St18, we observe a large expansion of cortical interneurons at the expense of putative GPe neurons. Through gene expression analysis we identified a downstream effector of St18, Cbx7, which is a component of Polycomb repressor complex 1. We find that Cbx7 is essential for projection neuron-like migration and is not involved in St18-mediated projection neuron-like morphology. Our results characterize a novel transcriptional determinant that directs GPe prototypic projection neuron identity. Further, we identified a downstream target of St18, Cbx7, which regulates only the migratory behavior of long-range projection neurons, suggesting that specific features of MGE projection neuron identity may be governed in a compartmentalized fashion by distinct transcriptional modules downstream of St18.

Vortex breakdown mechanics of a laminar confined swirling flow with large expansion ratio using a non-uniform finite difference approximation

Abrupt expansions are a very frequent geometry in mechanical engineering systems, i.e. in combustion chambers, valves, heat exchangers or impinging cooling devices. However, despite the large number of devices that use this geometry, the expanded flow behaviour still needs further research to understand and predict the full system performance. This paper presents the application of the non-uniform finite difference approximation method developed in Sanmiguel et al. for the numerical characterisation of a confined swirling laminar jet discharging with a large expansion ratio. This investigation can be considered an extension of previous work by Revuelta, but now a swirling flow is generated by a rotating pipe upstream the expansion. The structures found when a fully-developed rotating Hagen-Poiseuille flow discharges into a much larger pipe section are summarised in a bifurcation diagram, whose coordinates are the Reynolds number of the jet ( Rej) and the swirl parameter ( L), for which the time-dependent, axisymmetric and incompressible Navier-Stokes equations are integrated numerically. For values of the jet Reynolds number below 200, there is a critical value of the swirl parameter above which stable vortex breakdown appears. For values of the Reynolds number above 200, three different behaviours are observed, and each performance appears for a critical value of the swirl parameter. When increasing the swirl parameter from zero, the flow becomes axisymmetrically unstable, showing an oscillatory behaviour. If further increasing the swirl intensity, the oscillatory flow coexists with a vortex breakdown bubble and, finally, a steady vortex breakdown is reached. The expansion ratio ε considered in all the simulations is 1[Formula: see text]. In previous literature, the exactness of the limiting critical Rej and L values that define these behaviours has been found to be influenced by the variability in the inlet profile conditions, which affects the expanded flow. This enhances the importance in the present investigation to accurately simulate the discharge pipe inlet profiles.