scholarly journals The impact of atrial mechanical function on age‐dependent presentation of neurocardiogenic syncope

2021 ◽  
Author(s):  
Melani Sotiriadou ◽  
Christodoulos E. Papadopoulos ◽  
Antonios P. Antoniadis ◽  
Panagiotis Roumelis ◽  
Stavros Vergopoulos ◽  
...  
2018 ◽  
Vol 7 (2) ◽  
pp. 137-145 ◽  
Author(s):  
I. N. Mamchur ◽  
T. Y. Chichkova ◽  
V. N. Karetnikova ◽  
S. E. Mamchur ◽  
M. P. Romanova

The article presents new insights into the left atrial mechanical function, its main components and remodeling mechanisms after pulmonary vein antrum isolation. Left atrium is a cardiac chamber that transports blood. Being a complex «organ» both in anatomical and functional terms, it responds to hemodynamic derangements, the impact of humoral and vegetative factors. Structural, mechanical and electrical remodeling of the left atrium play a key role in the arrhythmogenesis of atrial fibrillation, as well as in the mechanism of arrhythmia maintenance. Left atrial mechanical dysfunction following catheter ablation of atrial fibrillation significantly affects intracardiac hemodynamics, worsens patients' well-being, and increases the risk of thromboembolic complications both in the immediate and long-term postoperative period.


2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
T Weimar ◽  
Y Watanabe ◽  
T Kazui ◽  
US Lee ◽  
MR Moon ◽  
...  

2018 ◽  
Vol 27 ◽  
pp. S196 ◽  
Author(s):  
A. Brennan ◽  
W. Martin ◽  
M. Yii

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1625
Author(s):  
Theresa C. Sutherland ◽  
Arthur Sefiani ◽  
Darijana Horvat ◽  
Taylor E. Huntington ◽  
Yuanjiu Lei ◽  
...  

The age of incidence of spinal cord injury (SCI) and the average age of people living with SCI is continuously increasing. However, SCI is extensively modeled in young adult animals, hampering translation of research to clinical applications. While there has been significant progress in manipulating axon growth after injury, the impact of aging is still unknown. Mitochondria are essential to successful neurite and axon growth, while aging is associated with a decline in mitochondrial functions. Using isolation and culture of adult cortical neurons, we analyzed mitochondrial changes in 2-, 6-, 12- and 18-month-old mice. We observed reduced neurite growth in older neurons. Older neurons also showed dysfunctional respiration, reduced membrane potential, and altered mitochondrial membrane transport proteins; however, mitochondrial DNA (mtDNA) abundance and cellular ATP were increased. Taken together, these data suggest that dysfunctional mitochondria in older neurons may be associated with the age-dependent reduction in neurite growth. Both normal aging and traumatic injury are associated with mitochondrial dysfunction, posing a challenge for an aging SCI population as the two elements can combine to worsen injury outcomes. The results of this study highlight this as an area of great interest in CNS trauma.


Heart Rhythm ◽  
2017 ◽  
Vol 14 (5) ◽  
pp. 710-716 ◽  
Author(s):  
Augustin Coisne ◽  
Rosario Pilato ◽  
François Brigadeau ◽  
Didier Klug ◽  
Christelle Marquie ◽  
...  

2010 ◽  
Vol 28 ◽  
pp. e79
Author(s):  
S Hoshide ◽  
Y Yano ◽  
M Shimizu ◽  
T Kabutoya ◽  
Y Matsui ◽  
...  

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157433 ◽  
Author(s):  
Kyung-Jin Kim ◽  
Hong-Mi Choi ◽  
Yeonyee E. Yoon ◽  
Hack-Lyoung Kim ◽  
Seung-Pyo Lee ◽  
...  

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