Metastatic melanoma to lymph nodes in patients with unknown primary sites

Cancer ◽  
2006 ◽  
Vol 106 (9) ◽  
pp. 2012-2020 ◽  
Author(s):  
Janice N. Cormier ◽  
Yan Xing ◽  
Lei Feng ◽  
Xuelin Huang ◽  
Latunya Davidson ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Metastatic Melanoma ◽  
Unknown Primary

Lymph Node Melanosis in a Patient With Metastatic Melanoma of Unknown Primary

2009 ◽  
Vol 133 (8) ◽  
pp. 1332-1334
Author(s):  
Patrick Malafronte ◽  
Timothy Sorrells
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Metastatic Melanoma ◽  
Axillary Dissection ◽  
Unknown Primary ◽  
Immunohistochemical Markers ◽  
Hmb 45

Abstract Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic lineage (S100, HMB-45, Melan-A). This process is rarely described in lymph nodes. We present a report of a patient with melanosis involving multiple lymph nodes of an axillary dissection, done for metastatic melanoma with an unknown primary, and discuss possible prognostic and treatment factors.

scholarly journals Metastatic Melanoma of Uncertain Primary with 5-Year Durable Response after Conventional Therapy: A Case Report with Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Jomjit Chantharasamee ◽  
Jitsupa Treetipsatit
Keyword(s):  
Lymph Nodes ◽  
Ct Scan ◽  
Metastatic Melanoma ◽  
Unknown Primary ◽  
Conventional Chemotherapy ◽  
Durable Response ◽  
Inguinal Lymph Nodes ◽  
Radiation Fields ◽  
Physical Examinations ◽  
Leg Edema

A 51-year-old Thai woman presented with bilateral leg edema and painful left inguinal mass for 6 months. Physical examination revealed matted bilateral inguinal lymph nodes up to 9 cm in size. Otherwise, physical examinations including skin were unremarkable. The result of the lymph node incisional biopsy is consistent with that of metastatic melanoma. The extensive investigation demonstrated multiple intra-abdominal and inguinal lymph nodes without detectable primary tumor. Palliative radiation and conventional chemotherapy were prescribed. The CT scan between treatments showed that the response was stable disease, but the following CT scan demonstrated a gradual decrease in size from August 2012 to November 2017 including the lesions outside radiation fields. Moreover, she developed vitiligo during a follow-up visit. The previous data reported the median overall survival among the patients who were treated with conventional chemotherapy ranging from 9.1 to 9.3 months and whose 5-year survival was less than 10%. This case represented a metastatic melanoma of unknown primary who achieved a durable response by conventional treatment. The clinical features including nodal-only disease, vitiligo, and abscopal effect of radiation were considered to be the favorable factors.

ENT private eye for unknown primary metastatic lymph nodes

ORL ro ◽  
2019 ◽  
Vol 1 (42) ◽  
pp. 20
Author(s):  
Daniela Vrînceanu ◽  
Mihai Dumitru ◽  
Adriana Nica
Keyword(s):  
Lymph Nodes ◽  
Unknown Primary ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Private Eye

Cervical Lymph Nodes and Unknown Primary Tumors of the Head and Neck

2016 ◽  
pp. 67-78 ◽  
Author(s):  
Snehal G. Patel ◽  
William M. Lydiatt ◽  
John A. Ridge ◽  
Christine M. Glastonbury ◽  
Suresh K. Mukherji ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Unknown Primary ◽  
Cervical Lymph Nodes ◽  
Primary Tumors ◽  
Unknown Primary Tumors

scholarly journals Expression of Glycolysis-Related Proteins in Cancer of Unknown Primary Origin

2021 ◽  
Vol 11 ◽  
Author(s):  
Murilo Bonatelli ◽  
Isabella Fernandes Fornari ◽  
Priscila Neves Bernécule ◽  
Lara Esquiapatti Pinheiro ◽  
Ricardo Filipe Alves Costa ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Nodes ◽  
Glucose Transporter ◽  
Metastatic Cancer ◽  
Multivariable Analysis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Primary Origin ◽  
Related Proteins ◽  
Unknown Primary Origin

IntroductionCancer of unknown primary origin (CUP) is defined as metastatic cancer without identification of the primary site. Considering that only 15–20% of patients with CUP show a favorable outcome, identifying biomarkers may help improve the clinical management of patients who do not respond well to conventional therapies. In this context, the study of the metabolic profile of CUP may pave the way to establish new biomarkers and/or therapeutic targets; therefore, this study aimed to characterize the expression of metabolism-related proteins in CUP.Materials and MethodsThe expression of monocarboxylate transporters MCT1, MCT2 and MCT4, their chaperone CD147, the glucose transporter GLUT1 and the pH regulator CAIX was evaluated by immunohistochemistry in a series of 118 CUP patients, and the results were associated with the available clinicopathological information.ResultsThe metabolism-related proteins MCT1, MCT4, CD147, GLUT1 and CAIX were expressed in a critical portion of the CUP (approximately 20 to 70%). MCT1 and CD147 were both more frequently expressed in cases with lymph nodes as metastasis dominant sites (p = 0.001) as well as in samples from lymph nodes (p <0.001 and p = 0.002, respectively), while MCT1 expression was more frequently expressed in squamous cell carcinomas (p = 0.045). A higher overall survival was observed in patients with tumors positive for GLUT1 and CAIX expression (p = 0.011 and p = 0.041, respectively), but none of the proteins was an independent prognostic factor for overall survival in multivariable analysis.ConclusionThe results suggest that a portion of CUPs present a hyperglycolytic phenotype, which is associated with higher overall survival.

scholarly journals Left Supraclavicular Lymphadenopathy as the Only Clinical Presentation of Prostate Cancer: A Case Report

2017 ◽  
Vol 17 (2) ◽  
pp. 41-44 ◽  
Author(s):  
Mohanad Abusultan ◽  
Pavel Hanzel ◽  
D. Durcansky ◽  
A. Hajtman
Keyword(s):  
Prostate Cancer ◽  
Lymph Nodes ◽  
Clinical Presentation ◽  
Cervical Lymphadenopathy ◽  
Cervical Lymph Node Metastasis ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Regional Lymph Nodes ◽  
Node Metastasis ◽  
Male Patients

AbstractProstate cancer usually metastasis to the regional lymph nodes and can rarely metastases to nonregional supradiaphragmatic lymph nodes. Cervical lymph node metastasis of prostate cancer is extremely rare. However, it should be considered in the differential diagnosis of cervical lymphadenopathy in male patients with adenocarcinoma of unknown primary site. In this report we present a rare case of metastatic prostate adenocarcinoma with left supraclavicular lymphadenopathy as the only clinical presentation with no other evidence of metastasis to the regional lymph nodes or bone metastasis.

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