Granule cells of the olfactory tubercle and the question of the islands of calleja

1987 ◽  
Vol 265 (1) ◽  
pp. 1-24 ◽  
Author(s):  
O. E. Millhouse
Keyword(s):  
Granule Cells ◽  
Olfactory Tubercle ◽  
Islands Of Calleja

Granule cells in the rat olfactory tubercle accumulate3H-γ-aminobutyric acid

1983 ◽  
Vol 215 (4) ◽  
pp. 465-471 ◽  
Author(s):  
Neil R. Krieger ◽  
John R. Megill ◽  
Peter Sterling
Keyword(s):  
Granule Cells ◽  
Aminobutyric Acid ◽  
Olfactory Tubercle

Aggregations of granule cells in the basal forebrain (islands of Calleja): Golgi and cytoarchitectonic study in different mammals, including man

1989 ◽  
Vol 284 (3) ◽  
pp. 405-428 ◽  
Author(s):  
Gundela Meyer ◽  
Tomas Gonzalez-Hernandez ◽  
Francisco Carrillo-Padilla ◽  
Romualdo Ferres-Torres
Keyword(s):  
Basal Forebrain ◽  
Granule Cells ◽  
Islands Of Calleja

scholarly journals PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Susanne Prokop ◽  
Péter Ábrányi-Balogh ◽  
Benjámin Barti ◽  
Márton Vámosi ◽  
Miklós Zöldi ◽  
...  
Keyword(s):  
Granule Cells ◽  
Enzyme Inhibitor ◽  
Antidepressant Drug ◽  
Super Resolution ◽  
Dependent Manner ◽  
Cell Type ◽  
Interaction Sites ◽  
Islands Of Calleja ◽  
High Affinity Receptor

AbstractImmunolabeling and autoradiography have traditionally been applied as the methods-of-choice to visualize and collect molecular information about physiological and pathological processes. Here, we introduce PharmacoSTORM super-resolution imaging that combines the complementary advantages of these approaches and enables cell-type- and compartment-specific nanoscale molecular measurements. We exploited rational chemical design for fluorophore-tagged high-affinity receptor ligands and an enzyme inhibitor; and demonstrated broad PharmacoSTORM applicability for three protein classes and for cariprazine, a clinically approved antipsychotic and antidepressant drug. Because the neurobiological substrate of cariprazine has remained elusive, we took advantage of PharmacoSTORM to provide in vivo evidence that cariprazine predominantly binds to D3 dopamine receptors on Islands of Calleja granule cell axons but avoids dopaminergic terminals. These findings show that PharmacoSTORM helps to quantify drug-target interaction sites at the nanoscale level in a cell-type- and subcellular context-dependent manner and within complex tissue preparations. Moreover, the results highlight the underappreciated neuropsychiatric significance of the Islands of Calleja in the ventral forebrain.

Age-dependent alterations in the number, volume, and localization of islands of Calleja within the olfactory tubercle

2013 ◽  
Vol 34 (11) ◽  
pp. 2676-2682 ◽  
Author(s):  
Stacey Adjei ◽  
Alexandra L. Houck ◽  
Katherine Ma ◽  
Daniel W. Wesson
Keyword(s):  
Olfactory Tubercle ◽  
Age Dependent ◽  
Islands Of Calleja

Ultrasturcture of cerebellar cells and neuropil in rats subjected to partial global cerebral ischemia

1986 ◽  
Vol 44 ◽  
pp. 126-127
Author(s):  
R.V.W. Dimlich ◽  
M.H. Biros
Keyword(s):  
Purkinje Cells ◽  
Glial Cells ◽  
Granule Cells ◽  
Molecular Layer ◽  
Cell Types ◽  
Primary Objective ◽  
Global Cerebral Ischemia ◽  
Forebrain Ischemia ◽  
Substantial Evidence ◽  
Cerebellar Cells

Although a previous study in this laboratory determined that Purkinje cells of the rat cerebellum did not appear to be damaged following 30 min of forebrain ischemia followed by 30 min of reperfusion, it was suggested that an increase in rough endoplasmic reticulum (RER) and/or polysomes had occurred in these cells. The primary objective of the present study was to morphometrically determine whether or not this increase had occurred. In addition, since there is substantial evidence that glial cells may be affected by ischemia earlier than other cell types, glial cells also were examined. To ascertain possible effects on other cerebellar components, granule cells and neuropil near Purkinje cells as well as neuropil in the molecular layer also were evaluated in this investigation.

Effects of aging on axon terminals in the dentate molecular layer

1987 ◽  
Vol 45 ◽  
pp. 928-929
Author(s):  
K. Cullen-Dockstader ◽  
E. Fifkova
Keyword(s):  
Granule Cells ◽  
Molecular Layer ◽  
Age Groups ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Perforant Path ◽  
Axon Terminals ◽  
Fischer 344 ◽  
Spatial Memory Deficit ◽  
Effects Of Aging

Normal aging results in a pronounced spatial memory deficit associated with a rapid decay of long-term potentiation at the synapses between the perforant path and spines in the medial and distal thirds of the dentate molecular layer (DML), suggesting the alteration of synaptic transmission in the dentate fascia. While the number of dentate granule cells remains unchanged, and there are no obvious pathological changes in these cells associated with increasing age, the density of their axospinous contacts has been shown to decrease. There are indications that the presynaptic element is affected by senescence before the postsynaptic element, yet little attention has been given to the fine structure of the remaining axon terminals. Therefore, we studied the axon terminals of the perforant path in the DML across three age groups.5 Male rats (Fischer 344) of each age group (3, 24 and 30 months), were perfused through the aorta.

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