Plasma levels and absorption of methaqualone after oral administration to man

1972 ◽  
Vol 13 (5part1) ◽  
pp. 719-723 ◽  
Author(s):  
Robert N. Morris ◽  
Gwendolyn A. Gunderson ◽  
Steven W. Babcock ◽  
John F. Zaroslinski
1997 ◽  
Vol 16 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Alison F Lailey

1 Perfluoroisobutene, a pyrolysis product of polytetra fluoroethene may cause pulmonary oedema and death when inhaled. Oral N-acetylcysteine has shown protection against inhalation of perfluoroisobutene and in this study we have tried to elucidate the mechanism by which protection is mediated. 2 Protection against the lethal effects of inhaled per fluoroisobutene has been shown when N-acetylcys teine has been orally administered 4, 6 or 8 h before gas exposure. 3 Plasma levels of cysteine, glutathione and N-acetylcys teine were increased for up to 7 h following oral administration of Nac. 4 N-acetylcysteine was not detected in the bronchio alveolar lavage fluid following oral administration. 5 Duration of protection in vivo has been related to the duration of increased thiol levels in the plasma.


1988 ◽  
Vol 69 (6) ◽  
pp. 900-904 ◽  
Author(s):  
Gregory C. Allen ◽  
Charles B. Cattran ◽  
Robert G. Peterson ◽  
Marcel Lalande

1986 ◽  
Vol 75 (11) ◽  
pp. 1107-1112 ◽  
Author(s):  
J.W. Cox ◽  
W.M. Bothwell ◽  
R.H. Pullen ◽  
M.A. Wynalda ◽  
F.A. Fitzpatrick ◽  
...  

1968 ◽  
Vol 9 (6) ◽  
pp. 777-782 ◽  
Author(s):  
George T. Bryan ◽  
John F. Worzalla ◽  
Arnold L. Gorske ◽  
G. Ramirez

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