scholarly journals Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients

2021 ◽  
Author(s):  
Nuha Mohamed Gaafar ◽  
Tarig Al‐Hadi Osman ◽  
Israa Abdulrahman Ahmed ◽  
Mariam Elsheikh ◽  
Harsh Dongre ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Immune Cell ◽  
Tumor Stroma ◽  
Squamous Cell Carcinomas ◽  
Cell Infiltrate ◽  
Oral Squamous Cell Carcinomas ◽  
Immune Cell Infiltrate

scholarly journals Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas

2022 ◽  
Author(s):  
Luca Hladek ◽  
Katrin Bankov ◽  
Jens von der Grün ◽  
Natalie Filmann ◽  
Melanie Demes ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell ◽  
Survival Data ◽  
Immune Cell ◽  
Tumor Biology ◽  
Squamous Cell Carcinomas ◽  
Cell Infiltrate ◽  
Advanced Tumor ◽  
Tumor Stages ◽  
Immune Cell Infiltrate

AbstractPenile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed.

Pathologic and imunohistochemical characterization of tumoral inflammatory cell infiltrate in invasive penile squamous cell carcinomas: Fox-P3 expression is an independent predictor of recurrence

Tumor Biology ◽  
2015 ◽  
Vol 36 (4) ◽  
pp. 2509-2516 ◽  
Author(s):  
José Vassallo ◽  
André Fellipe Freitas Rodrigues ◽  
Antonio Hugo J. F. M. Campos ◽  
Rafael Malagoli Rocha ◽  
Isabela Werneck da Cunha ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Inflammatory Cell ◽  
Independent Predictor ◽  
Squamous Cell Carcinomas ◽  
Inflammatory Cell Infiltrate ◽  
Cell Infiltrate

Immunohistochemical characterization of immune cell infiltrate in gastrointestinal stromal tumor and its prognostic correlation

2020 ◽  
Vol 40 (2) ◽  
pp. 229
Author(s):  
Reham S. ElNemr Esmail ◽  
YousryW Nada ◽  
Amr Kamal ◽  
Hussein ElSayed ◽  
NohaM El-Anwer
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Immune Cell ◽  
Stromal Tumor ◽  
Cell Infiltrate ◽  
Immune Cell Infiltrate

Effect of phenotype on outcome in synchronously resected primary colorectal cancer and matched liver metastases.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 221-221
Author(s):  
Kathryn AF Pennel ◽  
Colin William Steele ◽  
Jean A. Quinn ◽  
Antonia K. Roseweir ◽  
Rene Jackstadt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Poor Prognosis ◽  
Immune Cell ◽  
Primary Tumour ◽  
Tumor Stroma ◽  
Good Prognosis ◽  
Cell Infiltrate ◽  
Primary Tumors ◽  
Immune Cell Infiltrate

221 Background: 5-year survival of patients with resectable colorectal liver metastases is 25-40%. Mechanisms of disease progression are heterogenous and do not follow a clearly defined pathway from genotype to phenotype. In stage I-III colorectal cancer (CRC), patients with high tumor stroma exhibit poor prognosis, while those with high immune cell infiltrate do well following resection. We hypothesise that stromally-dense phenotypes lead to T cell exclusion, myeloid cell accumulation and aggressive metastatic progression. Here, we examine relationships between histological tumor phenotype, cellular infiltrate and outcomes in metastatic CRC. Methods: A unique cohort of synchronously resected primary CRC and matched liver metastases (n = 46) were assessed for immune cell infiltration (CD3, CD4, CD8, CD68, CD66b), inflammatory signalling (CXCR2, PDL-1, MMP9) and hypoxia (CAIX) using immunohistochemistry. Tumors were phenotypically subtyped using immune infiltrate (Klintrup-Makinen Grade (KM)), stromal invasion (tumor-stroma percentage (TSP)) and proliferation (Ki67). Results: Phenotypic subtype of primary tumors was predictive of metastatic subtype (rho = 0.522, p = 0.003). Immune phenotypes were associated with good prognosis and stromal phenotypes with poor prognosis (p = 0.004). Infiltration of macrophages and granulocytes associated with poor outcomes (p = 0.018) and increased CXCR2 expression (p = 0.03) at both sites. Increased CXCR2+ cells and macrophages at both sites associated with stromal phenotype (p = 0.02), tumour budding (p = 0.002), low KM grade (p = 0.05) and poor prognosis (p = 0.002). Macrophage and MMP9 levels increased in metastases compared to primary tumour, but no changes were seen in lymphocyte infiltration, CXCR2 and CD66b. Conclusions: Density of immune cell infiltrate, in the primary and metastatic niche, conferred good prognosis. In contrast, stromal, myeloid rich tumors convey poor prognosis. This clinically relevant and histologically efficient process permits segregation of disease and supports further study of relationships in the tumour microenvironment of CRC in the context of chemotherapy to better target therapeutics to individual patients.

Characterization of Tumor-Associated Antigens on Human Oral Squamous Cell Carcinomas Using Monoclonal Antibody 3F8E3

2000 ◽  
Vol 86 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Deepika Pichan ◽  
M. Loui Thomas ◽  
Anita Damodaran ◽  
Abdul R. Fakih ◽  
Shubhada V. Chiplunkar
Keyword(s):  
Monoclonal Antibody ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Tumor Associated Antigens

Characterization of novel cell lines established from three human oral squamous cell carcinomas

2002 ◽  
Author(s):  
Gene Lee ◽  
Youn-Bae Kim ◽  
Jin Kim ◽  
Myung-Soo Kim ◽  
Ki-Hyuk Shin ◽  
...  
Keyword(s):  
Cell Lines ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas

scholarly journals Characterization of human PA2.26 antigen (T1α-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas

2004 ◽  
Vol 113 (6) ◽  
pp. 899-910 ◽  
Author(s):  
Ester Martín-Villar ◽  
Francisco G. Scholl ◽  
Carlos Gamallo ◽  
Maria M. Yurrita ◽  
Mario Muñoz-Guerra ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas
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