scholarly journals EMT‐cancer cells‐derived exosomal miR‐27b‐3p promotes circulating tumour cells‐mediated metastasis by modulating vascular permeability in colorectal cancer

2021 ◽  
Vol 11 (12) ◽  
Author(s):  
Rongzhang Dou ◽  
Keshu Liu ◽  
Chaogang Yang ◽  
Jinsen Zheng ◽  
Dongdong Shi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Vascular Permeability ◽  
Tumour Cells ◽  
Circulating Tumour Cells

scholarly journals Therapeutic Targeting of the Tumour Microenvironment in Metastatic Colorectal Cancer

2021 ◽  
Vol 22 (4) ◽  
pp. 2067
Author(s):  
Rhynelle S. Dmello ◽  
Sarah Q. To ◽  
Ashwini L. Chand
Keyword(s):  
Colorectal Cancer ◽  
Targeted Therapy ◽  
Liver Metastasis ◽  
Metastatic Colorectal Cancer ◽  
Tumour Microenvironment ◽  
Tumour Cells ◽  
Cellular Interactions ◽  
Circulating Tumour Cells ◽  
Therapeutic Targeting ◽  
Colorectal Cancer Patients

Liver metastasis is the primary contributor to the death of patients with colorectal cancer. Despite the overall success of current treatments including targeted therapy, chemotherapy, and immunotherapy combinations in colorectal cancer patients, the prognosis of patients with liver metastasis remains poor. Recent studies have highlighted the importance of the tumour microenvironment and the crosstalk within that determines the fate of circulating tumour cells in distant organs. Understanding the interactions between liver resident cells and tumour cells colonising the liver opens new therapeutic windows for the successful treatment of metastatic colorectal cancer. Here we discuss critical cellular interactions within the tumour microenvironment in primary tumours and in liver metastases that highlight potential therapeutic targets. We also discuss recent therapeutic advances for the treatment of metastatic colorectal cancer.

P0036 The presence of clustered circulating tumour cells (CTCS) and circulating cytokines define an aggressive phenotype in metastatic colorectal cancer

2014 ◽  
Vol 50 ◽  
pp. e18-e19 ◽  
Author(s):  
R. Divella ◽  
A. Mazzocca ◽  
A. Daniele ◽  
A. Bellizzi ◽  
E. Savino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Aggressive Phenotype ◽  
Circulating Cytokines

scholarly journals Molecular markers in circulating tumour cells from metastatic colorectal cancer patients

2010 ◽  
Vol 14 (8) ◽  
pp. 2073-2077 ◽  
Author(s):  
Paola Gazzaniga ◽  
Angela Gradilone ◽  
Arianna Petracca ◽  
Chiara Nicolazzo ◽  
Cristina Raimondi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Colorectal Cancer Patients

Detection and enumeration of circulating tumour cells in colorectal cancer

1993 ◽  
Vol 80 (11) ◽  
pp. 1490-1490 ◽  
Author(s):  
A. Choy ◽  
P. G. McCulloch
Keyword(s):  
Colorectal Cancer ◽  
Tumour Cells ◽  
Circulating Tumour Cells

scholarly journals Significant diagnostic value of circulating tumour cells in colorectal cancer

2020 ◽  
Author(s):  
Haijiao Yu ◽  
Ling Ma ◽  
Yubing Zhu ◽  
Wenxia Li ◽  
Lei Ding ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Value ◽  
Tumour Cells ◽  
Circulating Tumour Cells

scholarly journals Tumour-Associated Transcripts and EGFR Deletion Variants in Colorectal Cancer in Primary Tumour, Metastases and Circulating Tumour Cells

2008 ◽  
Vol 30 (6) ◽  
pp. 463-471
Author(s):  
Silke Lankiewicz ◽  
Eva Rother ◽  
Silke Zimmermann ◽  
Christiane Hollmann ◽  
Firouzeh Korangy ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Primary Tumour ◽  
Clinical Status ◽  
Growth Factor Receptor ◽  
Drug Effects ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Egfr Expression ◽  
Epidermal Growth ◽  
Positive Controls

The clinical relevance of circulating tumour cells (CTC) in peripheral blood of patients with colorectal cancer (CRC) has been described as an independent prognostic factor useful to monitor drug effects and clinical status. The aim of the present study was to compare the epidermal growth factor receptor (EGFR) status of primary tumour, related metastases and CTC of patients with CRC. Therefore, in addition to EGFR, the tumour-associated transcripts gastrointestinal tumour-associated antigen 733-2 (GA733-2) and carcinoembryonic antigen (CEA) were analyzed in a multiplex RT-PCR to characterize CTC. 55% patients were positive for CTC. EGFR expression was detected in 18% of these patients. EGFR was expressed more frequently in metastatic and primary tumour tissues as revealed by immunohistochemistry. Besides, detailed expression profiling of EGFR variants in various colorectal and glioma cell lines has been performed to generate positive controls, resulting in the discovery of two new transcript deletion variations (cEX12_15del, cEX12_14del) located on the extracellular domain of the EGFR.

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