scholarly journals MYTH: An algorithm to score intratumour heterogeneity based on alterations of DNA methylation profiles

2021 ◽  
Vol 11 (10) ◽  
Author(s):  
Qian Liu ◽  
Lin Li ◽  
Xiaosheng Wang
Keyword(s):  
Dna Methylation ◽  
Intratumour Heterogeneity

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

15 LONGITUDINAL EVALUATION OF MUCOSAL DNA METHYLATION IN ULCERATIVE COLITIS SHOWS DISEASE-SPECIFIC CHANGES

2020 ◽  
Vol 158 (3) ◽  
pp. S50-S51
Author(s):  
Suresh Venkateswaran ◽  
Varun Kilaru ◽  
Hari Somineni ◽  
Jason Matthews ◽  
Jeffrey Hyams ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dna Methylation ◽  
Longitudinal Evaluation ◽  
Disease Specific

Aberrant DNA Methylation Is Associated with Reduced Response to SRC Inhibition in Primary Human Vestibular Schwannoma Cells

2019 ◽  
Author(s):  
Christine Dinh ◽  
Juan Young ◽  
Olena Bracho ◽  
Rahul Mittal ◽  
Denise Yan ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Vestibular Schwannoma ◽  
Aberrant Dna Methylation

Global DNA Methylation is influenced by smoking behavior

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
MAN Muschler ◽  
T Hillemacher ◽  
H Frieling ◽  
S Moskau ◽  
A Semmler ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Smoking Behavior ◽  
Global Dna Methylation

DNA Methylation Regulation

2020 ◽  
Author(s):  
Keyword(s):  
Dna Methylation

DNA Methylation and fMRI responses in patients with Cushing's syndrome in remission - suggestions of a functional link between hypercortisolism and neurocognitive dysfunction

2019 ◽  
Author(s):  
Camilla Glad ◽  
Johanna Andersson-Assarsson ◽  
Andreas Stomby ◽  
Per Dahlqvist ◽  
Lars Nyberg ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Functional Link ◽  
Neurocognitive Dysfunction

Maternal H3K27me3 controls DNA methylation-independent imprinting

2018 ◽  
Author(s):  
Inoue A ◽  
Jiang L ◽  
Lu F ◽  
Suzuki T ◽  
Zhang Y
Keyword(s):  
Dna Methylation

Deoxyribonucleic acid (DNA) methylation and its impact in generation of cancer

2014 ◽  
Vol 3 (3) ◽  
pp. 181
Author(s):  
J Rajeswari ◽  
GP Chakravarthi
Keyword(s):  
Dna Methylation ◽  
Deoxyribonucleic Acid
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