Clinicopathological significance of atypical glandular cells on cervicovaginal Pap smears

2017 ◽  
Vol 45 (10) ◽  
pp. 867-872 ◽  
Author(s):  
Mi-Kyung Kim ◽  
Yoo Kyung Lee ◽  
Sung Ran Hong ◽  
Kyung Taek Lim
Keyword(s):  
Pap Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Clinicopathological Significance

scholarly journals More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 22
Author(s):  
Pingping Zhong ◽  
Chenghong Yin ◽  
Yulan Jin ◽  
Tianbao Chen ◽  
Yang Zhan ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cervical Screening ◽  
Close Relation ◽  
Prior History ◽  
Pap Smears ◽  
Chi Square ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

Human papillomavirus DNA detection and histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in their Pap smears

2004 ◽  
Vol 95 (3) ◽  
pp. 618-623 ◽  
Author(s):  
Sophie Françoise Mauricette Derchain ◽  
Silvia Helena Rabelo-Santos ◽  
Luis Otávio Sarian ◽  
Luiz Carlos Zeferino ◽  
Eliane Regina de Oliveira Zambeli ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Dna Detection ◽  
Pap Smears ◽  
Adenocarcinoma In Situ ◽  
Histological Findings ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Papillomavirus Dna

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

2015 ◽  
Vol 59 (4) ◽  
pp. 315-318 ◽  
Author(s):  
Chiung-Ru Lai ◽  
Chih-Yi Hsu ◽  
Jen-Fan Hang ◽  
Anna Fen-Yau Li
Keyword(s):  
Pap Smear ◽  
Diagnostic Value ◽  
Routine Screening ◽  
Pap Smears ◽  
Cervical Lesions ◽  
Endometrial Cells ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Endometrial Cancers ◽  
New Criteria

Objective: The presence of degenerative endometrial debris and abnormal endometrial cells is considered to be the hint for endometrial pathology. The purpose of this study was to evaluate the efficacy of Papanicolaou (Pap) smears in detecting endometrial cancers. Study Design: There were 146 cases of endometrial cancer diagnosed at our institute in 2000-2002 and 271 in 2010-2012. Among them, 57 and 95 relevant reports of Pap smears 6 months prior to the histology diagnosis were retrieved for this study, respectively. In the first time period, new criteria for detecting endometrial lesions had not yet been incorporated into routine screening. Results: Twenty cases (21%) of adenocarcinoma, 12 (13%) of atypical glandular cells, 4 (4%) of endometrial debris and 59 (62%) negative reports were found among the more recent 95 relevant Pap smears. The overall efficacy of the Pap smear for detecting endometrial malignancy was 38%, higher than 10 years previously (30%). Conclusion: Although the Pap smear was originally designed to screen cervical lesions, more effective detection of endometrial lesions could be achieved by adding new criteria to the routine screening.

Clinical Significance of a Cytologic Diagnosis of Atypical Glandular Cells, Favor Endometrial Origin, in Pap Smears

2006 ◽  
Vol 50 (1) ◽  
pp. 48-54 ◽  
Author(s):  
Reda S. Saad ◽  
Hidehero Takei ◽  
Yulin L. Liu ◽  
Jan F. Silverman ◽  
Jane T. Lipscomb ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pap Smears ◽  
Cytologic Diagnosis ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals Correlation of Abnormal Pap Smears with Histopathologic Results: Philippine General Hospital Experience (2014-2017)

2019 ◽  
Vol 53 (1) ◽  
Author(s):  
Dahlia Teresa Ramirez Argamosa ◽  
Mark Angelo C. Ang ◽  
Agustina D. Abelardo ◽  
Michele H. Diwa1 ◽  
Christopher Alec A. Maquiling
Keyword(s):  
General Hospital ◽  
Concordance Rate ◽  
Lower Percentage ◽  
Pap Smears ◽  
Sampling Errors ◽  
Academic Center ◽  
Local Practices ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Intraepithelial Lesion

Objectives. To evaluate abnormal Papanicolau smear results at the Philippine General Hospital (PGH) for the past four years by comparing abnormal smear cytology with histologic interpretations. Possible causes of discrepant results were also determined. Methods. All Pap smears released as abnormal from January 2014 to December 2017 and the corresponding available biopsies were retrieved. Discrepancy between cytologic and histology diagnosis was assessed and pairs with major discordance were reviewed. Results. There were a total of 30,237 conventional pap smears signed out of which 239 (0.79%) were abnormal and only 56 (23%) had a subsequent tissue biopsy. The overall concordance rate is 75% while strict or absolute concordance rate is 32%. The overall discordance rate is 25%. Positive predictive value is highest for pap smears signed out as atypical glandular cells favor neoplastic (AGC-NEO) (100%), followed by malignant (93%), high grade squamous intraepithelial lesion (HSIL) (83%), and then atypical squamous cells cannot exclude an HSIL (ASC-H) and atypical squamous cell of undetermined significance (ASCUS), both at 67%. Conclusions. Considering that the Philippine General Hospital is a referral and academic center, we have a low percentage of abnormal pap smears compared to other developing countries and even a lower percentage of patients who had subsequent biopsies. Cytohistologic correlation detected interpretative as well as sampling errors, and the aim is to work on these deficiencies by improving quality assurance protocols and modifying current local practices of both pathologists and clinicians.

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